DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10081 and TRE1

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_015149.1	Gene:	TRE1 / 855927	SGDID:	S000006097	Length:	783	Species:	Saccharomyces cerevisiae

Alignment Length:	483	Identity:	105/483 - (21%)
Similarity:	165/483 - (34%)	Gaps:	151/483 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QANLYDFE-AIG--------TKVVGSDENE------HKTVQF-LLKELNL---IKDNIQEDLFDM 126
            :.|..||| |||        .:.:|.:|.:      .|..:| :..|.|:   :|.|:.:.|..|
Yeast    23 ELNSQDFEQAIGMPSEPPVYVEEMGMEEPQAPEAFSEKVQRFRMCFENNVVIPVKKNVVDPLAQM 87

  Fly   127 EIDLQYAYGAYVKWNLVNMYQGIQNVVVKLTPKGTTSENYILVNSHF-------DSQPTSPSTGD 184
             |.|     |..|::|  ....|.||:|      .....||::.|..       |..|...:.|.
Yeast    88 -ISL-----ASEKFDL--FLSKIGNVMV------MRRIFYIMMMSIIAALIIASDRLPNGKARGS 138

  Fly   185 DGHMVVSILEVLRVISSRRKS-----FEHPIIFLINGSEENSLQASHGFIAYHKWAKNCKAVINL 244
            :|    |..:...::...|||     .|..:.::   |....:..:.|..|...:.|.     :.
Yeast   139 NG----SFSDHDLLLQYARKSIDLSKIERDLEYI---SSMPHMSGTSGDAAIRHYIKE-----SF 191

  Fly   245 DAAG---SGGRELM-FQSGPNNPWLVKIYKDGAKHYFSTTMAEEIF-------QTGLVP-SYT-- 295
            |..|   :|..|.| :.:.|.|..| ::|.......|...:.||.|       |...:| .|.
Yeast   192 DKNGIRLAGEEEFMAYSNYPGNVSL-RVYSKDDTEGFDIPLNEENFNPMSHNGQLNNIPVIYANK 255

  Fly   296 -----------------DFDIFVEYGN------LIGLDIGQCINGFVYHTKYDRIDVIPRAAL-- 335
                             ||.:.|.||:      |...:.|.....|:.....|..|||...::
Yeast   256 ASLDDMASMQDQGLLNGDFILLVHYGDYVFQQMLTAQEYGAKAIIFISEPYQDNKDVIQMKSVAL 320

  Fly   336 --QNTGDNLL----GLVQTLSNASELR--------DLSANPTGNTIFFDVLGLYLISYSADVGVK 386
              ..|||.|.    |.::...:|:|.:        .:|||.          |..:::..:|.|||
Yeast   321 PQYGTGDALTPEWEGSIRDPIDATEAKCLPKIPSIPISANQ----------GDKILAILSDTGVK 375

  Fly   387 LNYAVAAAAIILIYISLL---RIAEKSSV--------SSEQILSTFILVLVVQLIAFVLALALPL 440
            .:..:.:.::....:.||   .|.|:..|        .|||             ....:.:|.|.
Yeast   376 FSNNLFSGSLNDCRLDLLVQTAIRERHPVHDIVGKIEGSEQ-------------AGRAIVIAAPR 427

  Fly   441 LVAYGLDKYGLSLSYFATPSL--LIGLY 466
            ..|    .||.....|.|..|  ||.||
Yeast   428 NSA----SYGTMYPSFGTVVLLSLIQLY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	81/381 (21%)
TRE1	NP_015149.1	PA	221..374	CDD:333703	31/162 (19%)
		M28_PMSA_TfR_like	402..617	CDD:349871	16/67 (24%)
		TFR_dimer	642..769	CDD:398094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900