DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10081 and TRE2

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_014899.1	Gene:	TRE2 / 854430	SGDID:	S000005782	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	310	Identity:	62/310 - (20%)
Similarity:	100/310 - (32%)	Gaps:	103/310 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 NLYDFEAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDL---FDMEIDLQYAYGAYVKWNLVN 144
            :|.|...:|.......||.....:..::...|:|.....:.   ||:.:|....||.:..: |.|
Yeast   517 SLIDISQLGIPFAEKYENGKTRGELSIETHPLLKKFFNRNAHGNFDISVDNVQHYGDWTPF-LAN 580

  Fly   145 MYQGIQNVVV-------KLTPKGTTSENYILVNSHFDSQPTSPSTG--------------DDGHM 188
               ||...|:       :.||..|:.:.:..|....:.:....|..              ||..:
Yeast   581 ---GIPVSVISSDSTRNRDTPTETSEDKFERVEKILEDEQNQQSVKDLLVYLLHISMELIDDPLL 642

  Fly   189 VVSILEVLRVISSRRKSFEHPIIFLIN--------------GSE--------ENSLQASHG---- 227
            ...|:..:..|..|.:..|......:|              |||        || :..|||
Yeast   643 HFDIISYVEDIDERLQRLEQAYPEKLNFTSIIKGLLFWKKIGSEWASWTQGWEN-IVWSHGDGIE 706

  Fly   228 --FIAYHKWAKNCKAVINLDAAGSGGRELMFQSG-PNNPWLVKIYKDGAKHYFSTTMAEE----- 284
              .::.::|..| |.:.|:      ||.....:| ||.    ..||:   ..|..|:.:|
Yeast   707 PSLLSINRWTWN-KKLTNI------GRRTCSPAGLPNR----SFYKN---VLFGPTLIQEDKSKN 757

  Fly   285 ----IFQT--GLVPSYTDFD--------------------IFVEYGNLIG 308
                .|.|  |::.:..|.|                    :|||..|.||
Yeast   758 GGNVDFWTFPGVMDAIYDDDWKRAQEQIDLIGKVLHQSAALFVEETNDIG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	62/310 (20%)
TRE2	NP_014899.1	PA	249..392	CDD:238300
		M28_PMSA_TfR_like	417..643	CDD:349871	24/129 (19%)
		TFR_dimer	668..799	CDD:398094	28/145 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900