DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10081 and VPS70

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_012660.1	Gene:	VPS70 / 853590	SGDID:	S000003887	Length:	811	Species:	Saccharomyces cerevisiae

Alignment Length:	413	Identity:	79/413 - (19%)
Similarity:	143/413 - (34%)	Gaps:	127/413 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RLPE-PLTVEDASKGGFIAERAQ---------ANLYDFEAIGTKVVGSDE-NEHKTVQFLLKELN 113
            |:|. |::..|...   |.||..         :|:.||.:........|: :.|..:.:.:||::
Yeast   364 RIPSVPMSARDVQP---ILERLNGRGFQIGPGSNIKDFGSFTGPSSSIDKVHLHNELTYNIKEMS 425

  Fly   114 LIKDNIQEDLFDMEIDLQYAYGAYVKWNLVNMYQGIQNVVVKLTPKGTTSENYILVNSHFDSQPT 178
            .::.:|                                       .|..:|..|::.:|.||..:
Yeast   426 SVEVSI---------------------------------------PGIFTEGEIIIGAHRDSLAS 451

  Fly   179 SPSTGDDGHMVVSILEVLRVISSRRKSFEH------PIIFLINGSEENSLQASHGFIAYHKWAKN 237
            | |.||.......:||:.|.:|   |..:|      ||..:....|.:.|..|..:...|.....
Yeast   452 S-SAGDANSGSAILLEIARGMS---KLLKHGWKPLRPIKLISWDGERSGLLGSTDYAEAHAAILR 512

  Fly   238 CKAVI--NLDAAGSGGRELMFQSGPN-----NPWLVKIYKDGAK--------------HYFSTTM 281
            .:|::  |||.|         .||.|     ||.|..:..:.||              |:..|:.
Yeast   513 RRALVYLNLDNA---------ISGTNFHCKANPLLQDVIYEAAKLTEFNGHEDWSLFDHWKYTSN 568

  Fly   282 AEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQC------INGFVYHT-----------KYDRIDV 329
            |......|| .|||.|...      :|:.....      .:|.|||:           |:...|.
Yeast   569 ATISLLDGL-SSYTSFQYH------LGVPAAHFQFNANDTSGAVYHSNSVFDSPTWLEKFTNSDY 626

  Fly   330 IPRAALQNTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKLNYAVAAA 394
                .|.||....:||...:.:.:||...:.:     ::...:..:.|::.:::...........
Yeast   627 ----KLHNTMAMFVGLTTLMLSENELARFNTH-----VYLKKIYNWYIAWHSNLSSAFPQDDEVN 682

  Fly   395 AIILIYISLLRIA-EKSSVSSEQ 416
            ::....:.||::| ::.|:..:|
Yeast   683 SLAKRVLDLLKVATQEDSIQFDQ 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	70/360 (19%)
VPS70	NP_012660.1	Zinc_peptidase_like	135..>187	CDD:417508
		PA_GCPII_like	187..413	CDD:239036	11/51 (22%)
		M28_PMSA_TfR_like	419..649	CDD:349871	60/292 (21%)
		TFR_dimer	<731..799	CDD:398094
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900