DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10081 and TFRC

DIOPT Version :9

Sequence 1:NP_611418.1 Gene:CG10081 / 37226 FlyBaseID:FBgn0034441 Length:875 Species:Drosophila melanogaster
Sequence 2:NP_001121620.1 Gene:TFRC / 7037 HGNCID:11763 Length:760 Species:Homo sapiens


Alignment Length:893 Identity:152/893 - (17%)
Similarity:272/893 - (30%) Gaps:364/893 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   173 FDSQPTSPS--------TGDDGH--MVVSILEVLRVISSRRKSFEHP--------------IIFL 213
            |..:|.|.:        .||:.|  |.:::.|.....::.:.:...|              |:|.
Human    13 FGGEPLSYTRFSLARQVDGDNSHVEMKLAVDEEENADNNTKANVTKPKRCSGSICYGTIAVIVFF 77

  Fly   214 INGSEENSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQSGPNNPWLVKIYKDGAKHYFS 278
            :.|       ...|::.|.|..:.......|....|..||   :.|.:.|...::|.|..|...|
Human    78 LIG-------FMIGYLGYCKGVEPKTECERLAGTESPVRE---EPGEDFPAARRLYWDDLKRKLS 132

  Fly   279 TTMAEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHTKYDRIDVIPRAALQNTGDNLL 343
            ..:....| ||.:                     :.:|...|         :||.|.....:||.
Human   133 EKLDSTDF-TGTI---------------------KLLNENSY---------VPREAGSQKDENLA 166

  Fly   344 GLVQT------LSNA--------SELRDLSANPTGNTIFFDVLG--LYL-------ISYS----- 380
            ..|:.      ||..        .:::|.:.|   :.|..|..|  :||       ::||     
Human   167 LYVENQFREFKLSKVWRDQHFVKIQVKDSAQN---SVIIVDKNGRLVYLVENPGGYVAYSKAATV 228

  Fly   381 ------ADVGVKLN----YAVAAAAIILIYISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLA 435
                  |:.|.|.:    |.....:|:::....:..|||.: ::|.:.:..:|:.:.|       
Human   229 TGKLVHANFGTKKDFEDLYTPVNGSIVIVRAGKITFAEKVA-NAESLNAIGVLIYMDQ------- 285

  Fly   436 LALPLLVAYGLDKYGLSLSYFATPSLLIGLYICPSLLGLTLPSYIYLK--------LANTEKVSF 492
            ...|::.|        .||:|....|..|....|.     .||:.:.:        |.|....:.
Human   286 TKFPIVNA--------ELSFFGHAHLGTGDPYTPG-----FPSFNHTQFPPSRSSGLPNIPVQTI 337

  Fly   493 AQQVQLALHGHAAVLSILCIAINYYGLRTTYVITWTLAFYVIPLAFNLLTTLHDRGYSWTGILKI 557
            ::.....|.|            |..|...:...|.:....|...:.|:..|:       :.:||.
Human   338 SRAAAEKLFG------------NMEGDCPSDWKTDSTCRMVTSESKNVKLTV-------SNVLKE 383

  Fly   558 VQVAPFMYNSYLFYCFIVILTPMMGRFGV---DTNPD--LIIG----------ALTALGTILSMG 607
            :::                    :..|||   ...||  :::|          |.:.:||.|.:.
Human   384 IKI--------------------LNIFGVIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLK 428

  Fly   608 FLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYRPKTNVQRVPYLQVRRIFYEYD---- 668
            ...:..:|..:.||                         :|..::          ||..:.    
Human   429 LAQMFSDMVLKDGF-------------------------QPSRSI----------IFASWSAGDF 458

  Fly   669 GTVSKDE--SGYLFNLQ---------DRRGL---------TPLLESNVDLTGLVNMTSDCAKYMM 713
            |:|...|  .|||.:|.         |:..|         :|||.:      |:..|....|:.:
Human   459 GSVGATEWLEGYLSSLHLKAFTYINLDKAVLGTSNFKVSASPLLYT------LIEKTMQNVKHPV 517

  Fly   714 CGMPLY-DHRWVEAME----------------------------------TTM--------WLPR 735
            .|..|| |..|...:|                                  |||        .:|.
Human   518 TGQFLYQDSNWASKVEKLTLDNAAFPFLAYSGIPAVSFCFCEDTDYPYLGTTMDTYKELIERIPE 582

  Fly   736 KNPVWTPAEPI-------------------------------LKQLNKTVLADGQTVQFEF---- 765
            .|.|...|..:                               |.|....:...|.::|:.:    
Human   583 LNKVARAAAEVAGQFVIKLTHDVELNLDYERYNSQLLSFVRDLNQYRADIKEMGLSLQWLYSARG 647

  Fly   766 -------ELTT----SDHTSIFISP--NEDVIISNWSFLKEYLTTNSPPY-HIYYSFG------- 809
                   .|||    ::.|..|:..  |:.|:...:.||..|::....|: |:::..|       
Human   648 DFFRATSRLTTDFGNAEKTDRFVMKKLNDRVMRVEYHFLSPYVSPKESPFRHVFWGSGSHTLPAL 712

  Fly   810 IDNTPLRFHIELKKADGVYTVPLFQMGIGAHYMHVKGDDESIRLANSL 857
            ::|..||     |:.:|.:...||:..:......::|      .||:|
Human   713 LENLKLR-----KQNNGAFNETLFRNQLALATWTIQG------AANAL 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10081NP_611418.1 M28_Fxna_like 72..379 CDD:193497 45/252 (18%)
TFRCNP_001121620.1 Mediates interaction with SH3BP4. /evidence=ECO:0000269|PubMed:16325581 1..67 9/53 (17%)
Endocytosis signal. /evidence=ECO:0000269|PubMed:2298808 20..23 0/2 (0%)
Stop-transfer sequence. /evidence=ECO:0000303|PubMed:6090955 58..61 1/2 (50%)
PA_TfR 201..377 CDD:239043 37/208 (18%)
M28_TfR 385..610 CDD:193572 44/285 (15%)
Ligand-binding 569..760 34/192 (18%)
TFR_dimer 642..750 CDD:282153 24/119 (20%)
Cell attachment site, required for binding to transferrin 646..648 0/1 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2234
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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