DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10081 and Tfrc

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_073203.1	Gene:	Tfrc / 64678	RGDID:	70488	Length:	761	Species:	Rattus norvegicus

Alignment Length:	954	Identity:	159/954 - (16%)
Similarity:	308/954 - (32%)	Gaps:	332/954 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GDKE----KLILDDHVEEGVKSYSRKHGRKHRVYFQLPWYFAGGIVLFWALLFIAVVKPLFYRLP 62
            ||..    ||..|:  ||...|..:...||       |..|.|      .|.|..:...:|:.:.
  Rat    31 GDNSHVEMKLAADE--EENADSNMKASVRK-------PKRFNG------RLCFATIAVVIFFLIG 80

  Fly    63 EPL-------TVEDASKGGFIAERAQANLYDFEAIGTKVVGSDENEHKTVQFLLKELNL----IK 116
            ..:       .||...:...:||..:|               |::|:...:::.|...|    :|
  Rat    81 FMIGYLGYCKRVEQKEECVRLAEAEEA---------------DKSENDETEYVPKSSRLFWADLK 130

  Fly   117 DNIQEDLFDME---IDLQYAYGAY------------VKWNLVNMYQGIQ-------NVVVKLTPK 159
            ..:.|.|..:|   |..|.:...|            :.:.:.|::...:       ...||:..|
  Rat   131 TLLSEKLNSIEFTDIIKQLSQNTYTPREAGSQKDENLAYYIENLFHDFKFSKVWRDEHYVKIQVK 195

  Fly   160 GTTSENYILVNSHFDSQPTSPSTGDDGHMVVSIL-----EVLRVISSRRKSFEHPIIFLINGSEE 219
            .:.|:|.:.:||..:..|..   ..:|::..|..     :::......:|.||. :.:.:|||
  Rat   196 NSVSQNLVTINSGSNIDPVE---APEGYVAFSKAGEVTGKLVHANFGTKKDFEE-LNYSVNGS-- 254

  Fly   220 NSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQSGPNNPWLVKIYKDGAKHYFSTTMAEE 284
             .:....|.|.:.:...|.:   :.:|.|                 |.||.|  ::.|....|:.
  Rat   255 -LVIVRAGKITFAEKVANAQ---SFNAIG-----------------VLIYMD--RNTFPVVEADL 296

  Fly   285 IF------QTG--LVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHTKY-----DRIDVIPRAALQ 336
            .|      .||  ..|.:..|:                      ||::     ..:..||
  Rat   297 QFFGHAHLGTGDPYTPGFPSFN----------------------HTQFPPSQSSGLPSIP----- 334

  Fly   337 NTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKLNYAVAAAAIILIYI 401
                     |||:|.|:          ...:|.::.|....|::.|...||.         |...
  Rat   335 ---------VQTISRAA----------AEKLFKNMEGNCPPSWNIDSSCKLE---------LSQN 371

  Fly   402 SLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLALALP---LLVAYGLDKYGLSLSYFATPSLLI 463
            ..:::...:.:...:||:.|         ..:.....|   ::|....|.:|
  Rat   372 QNVKLTVNNVLKETRILNIF---------GVIKGYEEPDRYIVVGAQRDAWG------------- 414

  Fly   464 GLYICPSLLGLTLPSYIYLKLANTEKVSFAQQVQLALHGHAAVLSILCIAINYYGLRTTYVITWT 528
                 |.:...::.:.:.||||.                   |.|.:.....:...|:....:||
  Rat   415 -----PGVAKSSVGTGLLLKLAQ-------------------VFSDMISKDGFRPSRSIIFASWT 455

  Fly   529 LAFY----VIPLAFNLLTTLHDRGYSWTGILKI--------VQVAPFMYNSYLFYCFIVILTPMM 581
            ...|    ........|::||.:.:::..:.|:        |..:|.:|.             :|
  Rat   456 AGDYGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYT-------------LM 507

  Fly   582 GRFGVDT-NPDLIIGALTALGTILSMGFLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFP 645
            |:...|. :|  |.|..                 :.|.|.::         :.:...|..:..||
  Rat   508 GKIMQDVKHP--IDGKY-----------------LYRDSNWI---------SKIEELSLDNAAFP 544

  Fly   646 YRPKTNVQRVPYLQVRRIFYEYDGTVSKDESGYLFNLQDRRGLTPLLESNVDLTG--LVNMTSDC 708
            :...:.:..|.:.......|.|.||  |.:: |...:|....|..::.:..::.|  ::.:|.|.
  Rat   545 FLAYSGIPAVSFCFCEDEDYPYLGT--KLDT-YEILIQKVPQLNQMVRTAAEVAGQFIIKLTHDI 606

  Fly   709 AKYMMCGMPLYDHRWVEAMETTMWLPRKNPVWTPAEPILKQLNKTVLADGQTVQFEF-------- 765
            .  :.....:|:.:.:..|:.                 |.|....:...|.::|:.:
  Rat   607 E--LTLDYEMYNSKLLSFMKD-----------------LNQFKADIKDMGLSLQWLYSARGDYFR 652

  Fly   766 ---ELTTSDH----TSIFI--SPNEDVIISNWSFLKEYLTTNSPPY-HIYYSFG-------IDNT 813
               .|||..|    |:.|:  ..|:.::...:.||..|::....|: ||::..|       ::|.
  Rat   653 ATSRLTTDFHNAEKTNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENL 717

  Fly   814 PLRFHIELKKADGVYTVPLFQMGIGAHYMHVKGDDESIRLANSL 857
            .||     :|....:...||:..:......::|      :||:|
  Rat   718 RLR-----QKNITAFNETLFRNQLALATWTIQG------VANAL 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	58/350 (17%)
Tfrc	NP_073203.1	Mediates interaction with SH3BP4. /evidence=ECO:0000250\|UniProtKB:P02786	1..67		13/50 (26%)
		Endocytosis signal. /evidence=ECO:0000250\|UniProtKB:P02786	20..23
		Stop-transfer sequence. /evidence=ECO:0000250\|UniProtKB:P02786	58..61		2/9 (22%)
		PA_TfR	201..378	CDD:239043	44/260 (17%)
		M28_TfR	386..611	CDD:349946	48/316 (15%)
		Ligand-binding. /evidence=ECO:0000250	570..761		37/212 (17%)
		TFR_dimer	638..751	CDD:398094	25/124 (20%)
		Cell attachment site, required for binding to transferrin. /evidence=ECO:0000250\|UniProtKB:P02786	647..649		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900