DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10081 and CG10073

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster

Alignment Length:	868	Identity:	534/868 - (61%)
Similarity:	668/868 - (76%)	Gaps:	2/868 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILDDHVEEGVKSYSRKHGRKHRVYFQLPWYFAGGIVLFWALLFIAVVKPLFYRLPEPLTVEDASK 72
            |.|:.:|:.|:|.|.|..:....|.:.|||.|.|.:|||||||.|||.|||||:|..||:|||||
  Fly    16 ISDEPIEDAVRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLPLFYRIPTGLTIEDASK 80

  Fly    73 GGFIAERAQANLYDFEAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDLFDMEIDLQYAYGAY 137
            |.|||||||:|||....|||||||||.||:|||.:|:..:|.|::|..:|.||:|:|||...|:|
  Fly    81 GVFIAERAQSNLYKLAEIGTKVVGSDNNENKTVDYLMGLVNEIQENCLDDYFDIEVDLQEVSGSY 145

  Fly   138 VKWNLVNMYQGIQNVVVKLTPKGTTSENYILVNSHFDSQPTSPSTGDDGHMVVSILEVLRVISSR 202
            :.|.:||||||:||:|:||:||.|||..|:||||||||:|||||.||.|.|||:|||||||:.|.
  Fly   146 IHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCST 210

  Fly   203 RKSFEHPIIFLINGSEENSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQSGPNNPWLVK 267
            :::..||::||:||:|||.||||||||..||||||||.|:||||||:||.:::||:|||:||||:
  Fly   211 KQAIRHPVVFLLNGAEENPLQASHGFITQHKWAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVE 275

  Fly   268 IYKDGAKHYFSTTMAEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHTKYDRIDVIPR 332
            .||:.|.||.:|||||||||||::||.|||.|||:||||||||:.:.||||.||||||:...|||
  Fly   276 KYKENAPHYLATTMAEEIFQTGILPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPR 340

  Fly   333 AALQNTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKLNYAVAAAAII 397
            .::|||||||||||::::|::||.:..|..||:.|||||||||.|||:...||.|||:||..|::
  Fly   341 GSIQNTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTESNGVILNYSVAGVALV 405

  Fly   398 LIYISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLALALPLLVAYGLDKYGLSLSYFATPSLL 462
            ||::|:.|.:..|.||...:|..|||:.|:|:|||||.|.||::|||..||||||::||:||.||
  Fly   406 LIFLSIWRTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLPIVVAYVFDKYGLSITYFSTPVLL 470

  Fly   463 IGLYICPSLLGLTLPSYIYLKLANTEKVSFAQQVQLALHGHAAVLSILCIAINYYGLRTTYVITW 527
            ||||||||||||:|||||||||..:|||.|||.:||.||||||||:||.|.:..||||:.||.||
  Fly   471 IGLYICPSLLGLSLPSYIYLKLQRSEKVGFAQHLQLVLHGHAAVLAILDIGLTVYGLRSAYVPTW 535

  Fly   528 TLAFYVIPLAFNLLTTLHDRGYSWTGILKIVQVAPFMYNSYLFYCFIVILTPMMGRFGVDTNPDL 592
            ||.|||||||.||||||||||:||||:|||.||.||:|||||.|||:|.|.|||||||..|||||
  Fly   536 TLIFYVIPLAVNLLTTLHDRGFSWTGVLKIFQVVPFLYNSYLIYCFVVTLIPMMGRFGRATNPDL 600

  Fly   593 IIGALTALGTILSMGFLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYRPKTNVQRVPY 657
            ||.||.||||||::||:|.||||.||...:|:.|||::|..:|.||||.|||||||||||||:||
  Fly   601 IISALCALGTILALGFVIPLVNMFRRPSLILLTLLAISAVTIYTASSTQIGFPYRPKTNVQRLPY 665

  Fly   658 LQVRRIFYEYDGTVSKDESGYLFNLQDRRGLTPLLESNVDLTGLVNMTSDCAKYMMCGMPLYDHR 722
            |.||||||||||||.|::||||||.|||||..||..|.::.||||::.:||...||||.||||||
  Fly   666 LHVRRIFYEYDGTVVKNDSGYLFNFQDRRGPAPLKLSKLNTTGLVSIAADCDTVMMCGFPLYDHR 730

  Fly   723 WVEAMETTMWLPRKNPVWTPAEPILKQLNKTVLADGQTVQFEFELTTSDHTSIFISPNEDVIISN 787
            ||:.....|||||:..:.||.||.|:.|:||.|.: .|::..|:..|:||.|:||.|.|||||||
  Fly   731 WVKNRLQIMWLPREEEIITPYEPKLELLSKTELGN-NTLRMNFQSATTDHASVFIQPLEDVIISN 794

  Fly   788 WSFLKEYLTTNSPPYHIYYSFGIDNTPLRFHIELKKADGVYTVPLFQMGIGAHYMHVKGDDESIR 852
            ||....|:...... |:|:|:|.:||.|.|.|:..|.|..:.|||.|:|:..|::..|||..|..
  Fly   795 WSLPTSYIGQQDTS-HMYFSYGKNNTALTFFIDFYKLDADFAVPLCQIGLAVHFIGNKGDAISQE 858

  Fly   853 LANSLPDYAVSIQWPAMYKKYIF 875
            .|..:|.:|.::.|||.|::|||
  Fly   859 FAKKIPSFAAAVDWPASYQRYIF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	199/306 (65%)
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	199/306 (65%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	162/239 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446887
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	217	1.000	Inparanoid score	I1221
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800