DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10081 and CG10051

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	879	Identity:	306/879 - (34%)
Similarity:	480/879 - (54%)	Gaps:	43/879 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EEGVKSYSRKHGRKHRVYFQLPWYFAGGIVLFWALLFIAVVKPLFYRLPEPL--TVEDASKGGFI 76
            ::|.||..:|.     .:|..|.|.|....||:     |.|.|.||..|:.|  :.|......||
  Fly    12 KDGGKSRDKKW-----PWFGAPIYAAAAFALFY-----AAVLPSFYSYPKMLYQSEEALHPDKFI 66

  Fly    77 AERAQANLYDFEAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDLFDMEIDLQYAYGAYVKWN 141
            .|||...|.::.|||.|:.||..||..|:.|||:|:..|||..:.||:|:|:|.||:.||:..|.
  Fly    67 GERAMRQLAEYSAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWG 131

  Fly   142 LVNMYQGIQNVVVKLTPKGTTSENYILVNSHFDSQPTSPSTGDDGHMVVSILEVLRVISSRRKSF 206
            :...|..:.|||||::.|.:.:|||:|||||:||:..:|:.||||.|||.:||.|||||...::.
  Fly   132 MTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTL 196

  Fly   207 EHPIIFLINGSEENSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQSGPNNPWLVKIYKD 271
            .||::||.||:||..:..|||||..|||:|||||::|||:.|:||||::||:|||:|||.|.|:.
  Fly   197 THPVVFLFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQA 261

  Fly   272 GAKHYFSTTMAEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHTKYDRIDVIPRAALQ 336
            ...|.::.|:|||:||...:||.|||.||.:||.:.|||:...:||:||||::|....:.....|
  Fly   262 SVPHPYAQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQ 326

  Fly   337 NTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKLNYAVAAAAIILI-- 399
            :||:|:|.|:..|:||.||.:.:|...|:|:::|.||.::::|:..|.:.:|..|:.||.|.|
  Fly   327 STGENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGT 391

  Fly   400 --YISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLALALPLLVAYGLDKYGLSLSYFATPSLL 462
              ||..|   :..:.:.:.::..|.::.:||.....:|..|.||||..:...||:.|::....:.
  Fly   392 SVYIMTL---DNGADAPKAVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYYGKWMA 453

  Fly   463 IGLYICPSL--LGLTLPSYI-YLKLANTEKVSFAQQVQLALHGHAAVLSILCIAINYYGLRTTYV 524
            .|||.|...  .|:...:|| :.|.....|:.  |.:...:|....:|::|||.:...|:|::|.
  Fly   454 FGLYFCTLFFAFGILPATYIGFTKRKTNMKLD--QTIACFMHAQCILLALLCIIMTIMGIRSSYF 516

  Fly   525 ITWTLAFYVIPLAFNLLTTLHDRGYSWTGILKIVQVAPFMYNSYLFYCFIVILTPMMGRFGVDTN 589
            ....:.||.|.:...::..|..:...:..:..:.||.||.:.:|:.|..:|...||.||.|.:::
  Fly   517 PMVGIFFYAISVLVQIVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDGPESS 581

  Fly   590 PDLIIGALTALGTILSMGFLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYRPKTNVQR 654
            ||::|........|...||:|.:::..|:...:......:|...:.:| .|..|||:..:...||
  Fly   582 PDIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILA-CTSAGFPFVKQLAPQR 645

  Fly   655 VPYLQVRRIFYEYDGTVSKDESGYLFNLQDRRGLTPLLESNVDLTGLVN------MTSDCAKYMM 713
            ...|..:|.|:..||| ||.:|||.....|.|    |.|  :|.|...|      ..:.||....
  Fly   646 YYVLHTQRTFHNLDGT-SKQDSGYYIQPVDTR----LHE--LDDTTFKNAEPESWTAATCAAEPY 703

  Fly   714 CGMPLYDHRWVEAMETTMWLPRKNPVWTPAEPILKQLNKTVLADGQTVQFEFELTTSDHTSIFIS 778
            ||:|||..||:|..::..|:....|| .|....|.||:|..| ||..|::|:.|..||...::|.
  Fly   704 CGLPLYSGRWIEWKDSARWIYSSPPV-IPMNINLTQLSKQSL-DGNKVRYEYNLRASDRVMMYID 766

  Fly   779 PNEDVIISNWSFLKEYLT-TNSPPYHIYYSFGIDNTPLRFHIELKKADGVYTVPLFQMGIGAHYM 842
            |.::|.:::|||....|. .::|||.||..:.....||.|.:||:..:|....|..::.:..|:.
  Fly   767 PLDNVKVTDWSFDHTPLVEKHTPPYLIYAIYSQTEEPLNFWVELEHEEGNTDGPYMKLVVSEHFQ 831

  Fly   843 HVKG--DDESIRLANSLPDYAVSIQWPAMYKKYI 874
            :...  .:|......:.||:..:..|.:..:.:|
  Fly   832 YHPEYYTEEYKEFLATFPDWTYTTDWFSALESWI 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	146/306 (48%)
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	146/306 (48%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	66/247 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446925
Domainoid	1	1.000	73	1.000	Domainoid score	I16173
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800