DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10081 and CG13160

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_001260918.1	Gene:	CG13160 / 36343	FlyBaseID:	FBgn0033720	Length:	875	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	388/883 - (43%)
Similarity:	560/883 - (63%)	Gaps:	26/883 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDKEKLILD-DHVEEGVKSYSRKHGRKHRVYFQLPWYFAGGIVLFWALLFIAVVKPLFYRLPEP 64
            :...|.||:: |..:...|.||              ||||...:|||..||.||:.|||..||..
  Fly    11 LSGSENLIIEVDEDKIRCKQYS--------------WYFAPIYLLFWVGLFFAVIYPLFQALPTG 61

  Fly    65 LTV-EDASK-GGFIAERAQANLYDFEAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDLFDME 127
            :.: |:|.| |.|:|||||..|.....:|.:|||..:||...|..||.|:..::..:::|:::||
  Fly    62 IKISEEADKPGQFVAERAQEILLQISRLGPRVVGDVDNEVTVVNLLLAEIEKVRQVLRDDVYEME 126

  Fly   128 IDLQYAYGAYVKWNLVNMYQGIQNVVVKLTPKGTTSENYILVNSHFDSQPTSPSTGDDGHMVVSI 192
            :::|.|.|:|:...|.|.|||:|||:|:|:.|.:.|.:|:|||||:|::|.||..|||..|||.:
  Fly   127 VEVQRASGSYLIKGLTNHYQGVQNVIVRLSTKSSNSTSYLLVNSHYDTKPGSPGAGDDAAMVVVM 191

  Fly   193 LEVLRVISSRRKSFEHPIIFLINGSEENSLQASHGFIAYHKWAKNCKAVINLDAAGSGGRELMFQ 257
            |||||:::.....|.||||||.||:||..:|.|||||..|:||.||||::|||:||:|||:|:||
  Fly   192 LEVLRLVAVSGDPFLHPIIFLFNGAEEQPMQGSHGFITQHRWAANCKALLNLDSAGAGGRDLLFQ 256

  Fly   258 SGPNNPWLVKIYKDGAKHYFSTTMAEEIFQTGLVPSYTDFDIFVEYGNLIGLDIGQCINGFVYHT 322
            .|||:|||::.|::.|.|.|:||.|||:|:.|::||.|||.||.::|.:.|||:....|||||||
  Fly   257 GGPNHPWLMEHYRNSAPHPFATTTAEEMFEAGIIPSDTDFRIFRDFGVVPGLDMAGVYNGFVYHT 321

  Fly   323 KYDRIDVIPRAALQNTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKL 387
            |:||..||...:|||:|||||.||.::|||.|:.|..|:..|:.:|||.:||:.:.|.....:.|
  Fly   322 KFDRYAVISLDSLQNSGDNLLALVWSISNAEEMYDTEAHAAGHAVFFDFIGLFFVHYQESTSLAL 386

  Fly   388 NYAVAAAAIILIYISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLALALPLLVAYGLDKYGLS 452
            |...:..||:|:.|||.|::..:..:.......|.|:.::.|...:||:|.|||:|...|....:
  Fly   387 NLFFSFGAILLVCISLWRMSRVTGQTMGTYAGVFGLLFLLALAGALLAVAFPLLMATFYDWGNRT 451

  Fly   453 LSYFATPSLLIGLYICPSLLGLTLPSYIYLKLANTEKVSFAQQVQLALHGHAAVLSILCIAINYY 517
            |:||:...|:||||||||::||.||..:||......|:.....:.:..|.:..:|:|||:.....
  Fly   452 LTYFSNSWLVIGLYICPSVIGLVLPMTLYLTHTKCNKIPHTYYLHIVGHANCVLLAILCLGATAL 516

  Fly   518 GLRTTYVITWTLAFYVIPLAFNLLTTLHDRGYSWTGILKIVQVAPFMYNSYLFYCFIVILTPMMG 582
            ..|:.|:...:|.|||..|..||||.||.|||.|:.:|.:.|:.||:|::|||:.||:||.||.|
  Fly   517 KYRSAYLFLISLIFYVAALIINLLTRLHCRGYLWSLVLIVFQIIPFIYHAYLFHMFILILIPMTG 581

  Fly   583 RFGVDTNPDLIIGALTALGTILSMGFLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYR 647
            ||||.||||::||||...||||::.|...|:|:.||...:|.||..|......||.| |:|||||
  Fly   582 RFGVSTNPDILIGALCGFGTILALSFAAPLINVFRRPNCMLGGLALVMFIFCMIAVS-DVGFPYR 645

  Fly   648 PKTNVQRVPYLQVRRIFYEYDGTVSKDESGYLFNLQDRRGLTPLLESNVDLTGLVNMTSDCAKYM 712
            |||||.|..::||.|.|:||:|::|.::|||.|:|.||....| |..:::||.||.:..||...:
  Fly   646 PKTNVMRADFMQVHRKFFEYNGSISHEDSGYYFHLGDRNKEAP-LRDHMNLTNLVRLGEDCDSEL 709

  Fly   713 MCGMPLYDHRWVEAMETTMWLPRKNPVWTPAEPILKQLNKTVLADGQTVQFEFELTTSDHTSIFI 777
            |||:|.|  |:..|.|..:||.|:.||..|...:|:.|:||||:.|..|::||.||...:..:|.
  Fly   710 MCGIPCY--RYCSAREHALWLAREEPVELPYPTVLEFLSKTVLSGGYQVRYEFRLTGPPNMGLFF 772

  Fly   778 SPNEDVIISNWSFLKEYL---TTNSPPYHIYYSFGIDNTPLRFHIELKKADGVYTVPLFQMGIGA 839
            .|.:.|.:..|:|....|   .|..||..:..::||||||:.|.:||.|.||.:..|:|:||:..
  Fly   773 KPLDGVKLLRWTFAPAMLDNPATYRPPLEVMLTYGIDNTPIEFFVELSKDDGNFNEPVFEMGVSG 837

  Fly   840 HYM--HVKGDDESIRLANSLPDYAVSIQWPAMYKKYIF 875
            ||:  |.|.|..|:....:|||:|.|::||:.|:::||
  Fly   838 HYVSPHDKRDALSLEFLATLPDFAFSMEWPSSYERHIF 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	156/307 (51%)
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:193497	155/306 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446889
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800