DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10081 and Tfrc

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	NP_001344227.1	Gene:	Tfrc / 22042	MGIID:	98822	Length:	763	Species:	Mus musculus

Alignment Length:	875	Identity:	163/875 - (18%)
Similarity:	289/875 - (33%)	Gaps:	307/875 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LFWALLFIAVVKPLFYRLPEPL-TVEDASKGGFIAERAQANLYDFEAIGTKVVGSDENEHKTVQF 107
            |:||.|     |.|   |.|.| ::|.|..   |.:.:| |.|.....|::   .||:....::.
Mouse   124 LYWADL-----KTL---LSEKLNSIEFADT---IKQLSQ-NTYTPREAGSQ---KDESLAYYIEN 173

  Fly   108 LLKELNLIKDNIQEDLFDMEIDLQYAYGAYVKWNLVNMYQGIQNVVVKLTPKGTTSENYILVNSH 172
            ...|....|  :..|...::|.::.:.|.    |:|.:.|...|:....:|:|     |:..
Mouse   174 QFHEFKFSK--VWRDEHYVKIQVKSSIGQ----NMVTIVQSNGNLDPVESPEG-----YVAF--- 224

  Fly   173 FDSQPTSPSTGDDGHMVVSILEVLRVISSRRKSFEHPIIFLINGSEENSLQASHGFIAYHKWAKN 237
              |:||..|    |.:|       ......:|.||. :.:.:|||   .:....|.|.:.:...|
Mouse   225 --SKPTEVS----GKLV-------HANFGTKKDFEE-LSYSVNGS---LVIVRAGEITFAEKVAN 272

  Fly   238 CKAVINLDAAGSGGRELMFQSGPNNPWLVKIYKDGAKHYFSTTMAE-EIF-----QTG--LVPSY 294
            .:   :.:|.|                 |.||.|  |:.|....|: .:|     .||  ..|.:
Mouse   273 AQ---SFNAIG-----------------VLIYMD--KNKFPVVEADLALFGHAHLGTGDPYTPGF 315

  Fly   295 TDFDIFVEYGNLIGLDIGQCINGFVYHTKYDRIDVIPRAALQNTG-DNLLGLVQTLSNASELRDL 358
            ..|:                      ||::      |.:  |::| .|:  .|||:|.|:
Mouse   316 PSFN----------------------HTQF------PPS--QSSGLPNI--PVQTISRAA----- 343

  Fly   359 SANPTGNTIFFDVLGLYLISYSADVGVKLNYAVAAAAIILIYISLLRIAEKSSVSSEQILSTFIL 423
                 ...:|..:.|.....::.|...||.         |.....:::..|:.:...:||:.|
Mouse   344 -----AEKLFGKMEGSCPARWNIDSSCKLE---------LSQNQNVKLIVKNVLKERRILNIF-- 392

  Fly   424 VLVVQLIAFVLALALP-LLVAYGLDKYGLSLSYFATPSLLIGLYICPSLLGLTLPSYIYLKLANT 487
                   ..:.....| ..|..|..:..|.....|..|:..||               .||||.
Mouse   393 -------GVIKGYEEPDRYVVVGAQRDALGAGVAAKSSVGTGL---------------LLKLAQ- 434

  Fly   488 EKVSFAQQVQLALHGHAAVLSILCIAINYYGLRTTYVITWTL----AFYVIPLAFNLLTTLHDRG 548
                              |.|.:.....:...|:....:||.    |..........|::||.:.
Mouse   435 ------------------VFSDMISKDGFRPSRSIIFASWTAGDFGAVGATEWLEGYLSSLHLKA 481

  Fly   549 YSWTGILKI--------VQVAPFMYNSYLFYCFIVILTPMMGRFGVDT-NPDLIIGALTALGTIL 604
            :::..:.|:        |..:|.:|.             :||:...|. :|  :.|.
Mouse   482 FTYINLDKVVLGTSNFKVSASPLLYT-------------LMGKIMQDVKHP--VDGK-------- 523

  Fly   605 SMGFLILLVNMSRRSGFVLIGLLAVTAAGVYIASSTDIGFPYRPKTNVQRVPYLQVRRIFYEYDG 669
                     ::.|.|.::         :.|...|..:..:|:...:.:..|.:.......|.|.|
Mouse   524 ---------SLYRDSNWI---------SKVEKLSFDNAAYPFLAYSGIPAVSFCFCEDADYPYLG 570

  Fly   670 TVSKDESGYLFNLQDRRGLT---PLLESNV----DLTG--LVNMTSDCAKYMMCGMPLYDHRWVE 725
            |          .|.....||   |.|...|    ::.|  ::.:|.|..  :.....:|:.:.:.
Mouse   571 T----------RLDTYEALTQKVPQLNQMVRTAAEVAGQLIIKLTHDVE--LNLDYEMYNSKLLS 623

  Fly   726 AMETTMWLPRKNPVWTPAEPILKQLN--KTVLAD-GQTVQFEF-----------ELTTSDH---- 772
            .|                    |.||  ||.:.| |.::|:.:           .|||..|
Mouse   624 FM--------------------KDLNQFKTDIRDMGLSLQWLYSARGDYFRATSRLTTDFHNAEK 668

  Fly   773 TSIFI--SPNEDVIISNWSFLKEYLTTNSPPY-HIYYSFG-------IDNTPLRFHIELKKADGV 827
            |:.|:  ..|:.::...:.||..|::....|: ||::..|       ::|..||     :|....
Mouse   669 TNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENLKLR-----QKNITA 728

  Fly   828 YTVPLFQMGIGAHYMHVKGDDESIRLANSL 857
            :...||:..:......::|      :||:|
Mouse   729 FNETLFRNQLALATWTIQG------VANAL 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	61/315 (19%)
Tfrc	NP_001344227.1	Mediates interaction with SH3BP4. /evidence=ECO:0000250	1..67
		Endocytosis signal	20..23
		Stop-transfer sequence	58..61
		PA_TfR	203..379	CDD:239043	52/273 (19%)
		Zinc_peptidase_like	387..613	CDD:326366	52/321 (16%)
		Ligand-binding. /evidence=ECO:0000250	572..763		43/214 (20%)
		TFR_dimer	645..749	CDD:309400	21/114 (18%)
		Cell attachment site. /evidence=ECO:0000255	649..651		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900