Protein Alignment CG10081 and NAALAD2

DIOPT Version :10

• Sequence 1: NP_611418.1
• Gene: CG10081 / 37226
• FlyBaseID: FBgn0034441
• Length: 875
• Species: Drosophila melanogaster
• Sequence 2: XP_016872532.1
• Gene: NAALAD2 / 10003
• HGNCID: 14526
• Length: 775
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 103/507 - (20%)
• Similarity: 181/507 - (35%)
• Gaps: 156/507 - (30%)

  Fly    41 GIVLFWALLFIAVVKPLFYRLPEPLTVEDASKG----GFIAERAQ----------------ANLY 85
            ||:|:        ..|..|..||   |:...||    |..|:|..                |..|
Human   249 GIILY--------SDPADYFAPE---VQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEY 302

  Fly    86 DF-----EAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDLFDMEIDLQYAYG-------AYV 138
            .|     |.:|...:......:...:.||:.|..|..  .:..:...:::.|:.|       ::.
Human   303 TFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAP--PDKSWKGALNVSYSIGPGFTGSDSFR 365

  Fly   139 KWNL----VNMYQGIQNVVVKLTPKGTTS-ENYILVNSHFDS---QPTSPSTGDDGHMVVSILEV 195
            |..:    :|....|.|||.  |.:|:.. :.|:::..|.||   ....|::|     |..:.|:
Human   366 KVRMHVYNINKITRIYNVVG--TIRGSVEPDRYVILGGHRDSWVFGAIDPTSG-----VAVLQEI 423

  Fly   196 LRVISSRRKSFEHP---IIFLINGSEENSLQASHGFIAYHKWA-KNCK-------AVINLDAAGS 249
            .|...........|   |||....:||      .|.:...:|| :|.|       |.||.|::..
Human   424 ARSFGKLMSKGWRPRRTIIFASWDAEE------FGLLGSTEWAEENVKILQERSIAYINSDSSIE 482

  Fly   250 GGRELMFQSGPNNPWLV-KIYK------DG--AKHYFSTTMAEE-------IFQTGLVPSYTDFD 298
            |...|.....|....|| |:.|      ||  :|..:.:.:.::       :.:...:.|.:||:
Human   483 GNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFE 547

  Fly   299 IFVEYGNLIGLDIGQC----------INGF-VYHTKYDRIDVIP----------------RAAL- 335
               .|...:|:..|:.          .:.: ||||.|:..:::.                |.||
Human   548 ---AYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALV 609

  Fly   336 -------------QNTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKL 387
                         |:..:.|.....::.|.|:..|...  |.:.:.||.|      :||   ||
Human   610 YELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQL--TDHGVSFDSL------FSA---VK- 662

  Fly   388 NYAVAAAAIILIYISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLALALP 439
            |::.||:.   .:..|:::...:.::...:....:|:    ..||:..|.||
Human   663 NFSEAASD---FHKRLIQVDLNNPIAVRMMNDQLMLL----ERAFIDPLGLP 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:349872	81/414 (20%)
NAALAD2	XP_016872532.1	Zinc_peptidase_like	94..>139	CDD:472712
		PA_GCPII_like	145..371	CDD:239036	25/134 (19%)
		M28_PSMA_like	366..620	CDD:349942	56/269 (21%)
		TFR_dimer	652..772	CDD:461238	17/73 (23%)