DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10081 and NAALAD2

DIOPT Version :9

Sequence 1:	NP_611418.1	Gene:	CG10081 / 37226	FlyBaseID:	FBgn0034441	Length:	875	Species:	Drosophila melanogaster
Sequence 2:	XP_016872532.1	Gene:	NAALAD2 / 10003	HGNCID:	14526	Length:	775	Species:	Homo sapiens

Alignment Length:	507	Identity:	103/507 - (20%)
Similarity:	181/507 - (35%)	Gaps:	156/507 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GIVLFWALLFIAVVKPLFYRLPEPLTVEDASKG----GFIAERAQ----------------ANLY 85
            ||:|:        ..|..|..||   |:...||    |..|:|..                |..|
Human   249 GIILY--------SDPADYFAPE---VQPYPKGWNLPGTAAQRGNVLNLNGAGDPLTPGYPAKEY 302

  Fly    86 DF-----EAIGTKVVGSDENEHKTVQFLLKELNLIKDNIQEDLFDMEIDLQYAYG-------AYV 138
            .|     |.:|...:......:...:.||:.|..|..  .:..:...:::.|:.|       ::.
Human   303 TFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAP--PDKSWKGALNVSYSIGPGFTGSDSFR 365

  Fly   139 KWNL----VNMYQGIQNVVVKLTPKGTTS-ENYILVNSHFDS---QPTSPSTGDDGHMVVSILEV 195
            |..:    :|....|.|||.  |.:|:.. :.|:::..|.||   ....|::|     |..:.|:
Human   366 KVRMHVYNINKITRIYNVVG--TIRGSVEPDRYVILGGHRDSWVFGAIDPTSG-----VAVLQEI 423

  Fly   196 LRVISSRRKSFEHP---IIFLINGSEENSLQASHGFIAYHKWA-KNCK-------AVINLDAAGS 249
            .|...........|   |||....:||      .|.:...:|| :|.|       |.||.|::..
Human   424 ARSFGKLMSKGWRPRRTIIFASWDAEE------FGLLGSTEWAEENVKILQERSIAYINSDSSIE 482

  Fly   250 GGRELMFQSGPNNPWLV-KIYK------DG--AKHYFSTTMAEE-------IFQTGLVPSYTDFD 298
            |...|.....|....|| |:.|      ||  :|..:.:.:.::       :.:...:.|.:||:
Human   483 GNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINKLGSGSDFE 547

  Fly   299 IFVEYGNLIGLDIGQC----------INGF-VYHTKYDRIDVIP----------------RAAL- 335
               .|...:|:..|:.          .:.: ||||.|:..:::.                |.||
Human   548 ---AYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALV 609

  Fly   336 -------------QNTGDNLLGLVQTLSNASELRDLSANPTGNTIFFDVLGLYLISYSADVGVKL 387
                         |:..:.|.....::.|.|:..|...  |.:.:.||.|      :||   ||
Human   610 YELVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQL--TDHGVSFDSL------FSA---VK- 662

  Fly   388 NYAVAAAAIILIYISLLRIAEKSSVSSEQILSTFILVLVVQLIAFVLALALP 439
            |::.||:.   .:..|:::...:.::...:....:|:    ..||:..|.||
Human   663 NFSEAASD---FHKRLIQVDLNNPIAVRMMNDQLMLL----ERAFIDPLGLP 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10081	NP_611418.1	M28_Fxna_like	72..379	CDD:193497	81/414 (20%)
NAALAD2	XP_016872532.1	Zinc_peptidase_like	93..>139	CDD:301362
		PA_GCPII_like	145..371	CDD:239036	25/134 (19%)
		M28_PSMA_like	373..620	CDD:193568	55/262 (21%)
		TFR_dimer	657..772	CDD:282153	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900