DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and PFF1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_009630.3	Gene:	PFF1 / 852366	SGDID:	S000000278	Length:	976	Species:	Saccharomyces cerevisiae

Alignment Length:	1048	Identity:	226/1048 - (21%)
Similarity:	359/1048 - (34%)	Gaps:	318/1048 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YLATGFLLFWALLFSAVVLPLFYRIPTGLTIEDASKGVFIAERAQSNLYK--------------- 94
            |..|...|.  ||.:..::.|.|              :|..||.:.||.|
Yeast    13 YRKTNLSLL--LLITYSIITLLY--------------IFDHERYKLNLPKEDEHPEFNDLLETAW 61

  Fly    95 --LAEIGTKVVGSDNNEN-KTVDYLMGLVNEIQEN----CLDDYFDIEVDL----QEVSGSYIHW 148
              |..|........:.|| |..|||:..|.||..|    .:.|..:.|..:    |:.......:
Yeast    62 GDLQIITASFHPYTSKENDKVHDYLLKRVLEITGNSSFASVSDDKESERSILFQQQDPFNESSRF 126

  Fly   149 TMVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQA 213
            :.|..::. .||::||..||..... ||:::||||.||...|.|.|..||::|      .:.|..
Yeast   127 SRVTYFES-SNILVKLEGKNPEEEG-LLLSAHFDSVPTGYGATDDGMGVVSLL------ANLKYH 183

  Fly   214 IRH----PVVFLLNGAEENPLQASHGFITQHKWAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLV 274
            |:|    .::|..|..||..|..:..:. .|.|:...|.|:||:..|.||..::|:|...|...:
Yeast   184 IKHRPNRTLIFNFNNNEEFGLLGASTYF-DHSWSNLTKYVINLEGTGAGGKAVLFRTSDTSTARI 247

  Fly   275 --EKYKENAPHYLATTMAEEIFQTGI----LPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKYD 333
              :..|||       .....|:|.|.    :.|:||:.|:.:.| :.|.|:|.:.....|||..|
Yeast   248 YQQSVKEN-------PFGNSIYQQGFYSRYVRSETDYKIYEENG-MRGWDVAFYKPRNLYHTIKD 304

  Fly   334 QFSNIPRGSIQNTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTES-----NGV 393
            ......:.|:.:.....|.|...:| |..||..:...   |.:||.:||.|...:..     |.:
Yeast   305 SIQYTSKASLWHMLHTSLQLSAYVA-SNSLDTADQTP---ACYFDFIGLKFFVISAKTLFYWNCI 365

  Fly   394 ILNYS-VAGVALVLIFLS--IWRTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLPIVVAYVFD 455
            .|..| |..:.|.||...  .|::.|           |      |....|.|.|...|:|..:|.
Yeast   366 FLLVSPVVAIGLYLISRDRMTWKSYS-----------W------LSWTRFPLSLAAGIIVQKLFS 413

  Fly   456 -------------KYGLSITYFSTPVLLIG---------LYICPSLLGLS-LPSYIYL------- 490
                         .|...|:.|.|.|:...         .:.|..:..|| :..:|.|
Yeast   414 NDIIRSNPLTFSRNYFWPISAFFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWTILLFT 478

  Fly   491 -KLQRSEKVGFAQHLQL----VLHGHAAVLAILDIGLTVYGLRS------------AYVPTWTLI 538
             ||..|....:.....|    :|...||:|.:|.:.|   |:|:            :...:.:.|
Yeast   479 SKLLYSSDYRYTGLYPLSIFFLLSTIAAILRLLALAL---GMRTRKRLGRECRDHHSNYSSHSQI 540

  Fly   539 FYVIPLAVNL------LT-------TLHDRGFSWTGVLKIFQV----------------VPFLYN 574
            ........||      ||       ::.|...|.|.......|                ||.|..
Yeast   541 DMERDGQENLEQPQDQLTSSQDDQASIQDDNVSTTSAGPSHNVDEDHGMDSSSQQHDERVPLLKG 605

  Fly   575 S-----------------YLIYCFVV--TLIPMMGRFGRATNPDLIISAL--------CALGTIL 612
            |                 |..|.:::  .||..:..|....:.|:|:.||        .|...:|
Yeast   606 SNSMEEGLSTRENSLKLEYTDYAWIIQFLLIVPIPSFILFNSVDVIMDALNHTVQEGSKATFDVL 670

  Fly   613 ALGFV------IPLVNMFRRPSLILLTLLAISAVTIYTASSTQIGFPYRPKTNVQRLPYLHVRRI 671
            ..|.|      :|::..|.:.:.|.::|.|:  :.:.:||.|.:..|:   ||...|.....:.|
Yeast   671 RFGMVGSILIALPILPFFYKVNYITISLTAL--LFLISASKTLLVHPF---TNSNPLKVRFSQNI 730

  Fly   672 FYEYDGTVVKNDSGYLFNFQDRRGPAPLK--LSKLNTTGLVSIAADCDTVM----MCGFPLYD-- 728
            ..........:..|...||        ||  |..|.:....|...:|.:|.    :|   :||
Yeast   731 DLSQGNAASVHVLGREGNF--------LKPMLQDLPSIKYSSTHINCTSVTNGMELC---MYDGM 784

  Fly   729 -------------HRWVKNRLQIMWLPREEEIITPYEPKL-ELLSKTELGNNTLRMNFQSATTDH 779
                         ...||  :.::...|.....:||||.: |||.:.: .|....:.|:|.   |
Yeast   785 QPNLLSTNGNTNISSMVK--VHVLHNNRNSTERSPYEPIVAELLLEVK-ENRACTLTFESR---H 843

  Fly   780 ASVFIQPLEDVIISNWSLPTSYIGQQDTSHMYFSYGKNNTA-----LTFFI---------DFYKL 830
            .:.  .|:.::.:                     |.|.|:|     :|..|         ..:||
Yeast   844 QAK--SPVREITV---------------------YQKKNSAPQKANITKTIKSASGINELQLHKL 885

  Fly   831 DAD----------FAVPLCQIGLAVHFIGNKGD----------------AISQEFAKKIPSFAAA 869
            |.|          |...|....:....:|.|.:                .::....:|||:|...
Yeast   886 DFDQETYHIGVQWFPKLLTDGNVEDDKLGTKDELSVSISCYWGEYDSESVVNGTAVRKIPAFDEL 950

  Fly   870 VDW-PASY 876
            ::: |.|:
Yeast   951 INYAPLSF 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	93/342 (27%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	68/351 (19%)
PFF1	NP_009630.3	M28_Fxna_like	50..354	CDD:349872	87/324 (27%)
PFF1	NP_009630.3	DUF2189	366..>443	CDD:413262	21/93 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343305
Domainoid	1	1.000	99	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm46574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840