DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and ERMP1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_079172.2	Gene:	ERMP1 / 79956	HGNCID:	23703	Length:	904	Species:	Homo sapiens

Alignment Length:	911	Identity:	280/911 - (30%)
Similarity:	443/911 - (48%)	Gaps:	156/911 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ATGFLLFWALLFSAVVLPLFYRIPTGLTIEDASKGVFIAERAQSNLYKLAEIGTKVVGSDNNENK 111
            |.|..|:...|.:.|.|.|...:..|..   ..:|.|.|.:|:..|..:..||.:..||..||..
Human    74 ALGLALYLIALRTLVQLSLQQLVLRGAA---GHRGEFDALQARDYLEHITSIGPRTTGSPENEIL 135

  Fly   112 TVDYLMGLVN--EIQENCLDDYFDIEVDLQEVSGSY-IHWT--MVNMYQGVQNIVIKLSPKNTTS 171
            ||.||:..:.  |:|.|.|   ..|.||:|..:||: |.:.  ..:.|..:.|:|:||.|::...
Human   136 TVHYLLEQIKLIEVQSNSL---HKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGAQ 197

  Fly   172 TTYLLVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQAIRHPVVFLLNGAEENPLQASHGF 236
            .. :|.|.||||...||.|.|.......:||||||:.::.:|:.|.|:||.||||||.|||||||
Human   198 HA-VLANCHFDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGF 261

  Fly   237 ITQHKWAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPS 301
            ||||.||...:..:||:|||.||.::||||||.:||||:.|...|.|..|:.:|:|:||:||:||
Human   262 ITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPS 326

  Fly   302 DTDFAIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGSIQNTGDNLLGLVRSIANSTELDNT 366
            ||||.|:..:||:.|:|:|...||:.||||||....|...|||..|||:|.:::.:|.|..|...
Human   327 DTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAA 391

  Fly   367 EAYATGHAIFFDVLGLYFISYTESNGVILNYSVA-GVALVL--IFLS-IWRTSSISRVSIGHVLC 427
            ..|..|:.:|||||||:.|:|....|.|:||.|. ||.|.|  .||. ..:|.:..:
Human   392 SKYRHGNMVFFDVLGLFVIAYPSRIGSIINYMVVMGVVLYLGKKFLQPKHKTGNYKK-------- 448

  Fly   428 WFILIFVLQIIAFVLGLGLPIVVAYVFDKYGLSITYFST--PVLLIGLYICPSLLGLSLPSYIYL 490
                       .|:.|||:.:            |::|::  .||:|.::|  ||:|.||..|.:.
Human   449 -----------DFLCGLGITL------------ISWFTSLVTVLIIAVFI--SLIGQSLSWYNHF 488

  Fly   491 KLQRSEKVGFAQHLQLVLHGHAAVLAIL------------------------DIGLTVY------ 525
                        ::.:.|:|.|.|..|:                        ||.|.|:
Human   489 ------------YVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEVFFDISLFVHCCFLVT 541

  Fly   526 ----GLRSAYVPTWTLIFYVIPLAVNLLTTLHDRGFSWTG---------VLKIFQVVPFLYNSYL 577
                ||.||::   :.::...||...|  .:| :.|...|         :|.:|  :|:||..||
Human   542 LTYQGLCSAFI---SAVWVAFPLLTKL--CVH-KDFKQHGAQGKFIAFYLLGMF--IPYLYALYL 598

  Fly   578 IYCFVVTLIPMMGRFGRATNPDLIISALCALGTILALGFVIPLVNMFRRPSLILLTLLAISAVTI 642
            |:.......|::||.|....||::::::.|..|::...:.|..:.:.:.....:|||..:.|:|.
Human   599 IWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKKTMLTLTLVCAITF 663

  Fly   643 YTASSTQIGFPY-----RPKTNVQRLPYLHVRRIFYEYDGTVVKNDSGYLFNFQDRRGPAPL--K 700
            ....|... |||     .||.  :|:...|:.|.|::.:|..||.|||...|..|..|.:.:  .
Human   664 LLVCSGTF-FPYSSNPANPKP--KRVFLQHMTRTFHDLEGNAVKRDSGIWINGFDYTGISHITPH 725

  Fly   701 LSKLNTTGLVSIAADC-DTVMMCGFPLY--DHRWVKNRLQIMWLPREEEIITPYE-PKLELLSKT 761
            :.::|.    ||.|.| :...:||||.|  .|..::..   .:||..|  ::|.. |...|:||.
Human   726 IPEIND----SIRAHCEENAPLCGFPWYLPVHFLIRKN---WYLPAPE--VSPRNPPHFRLISKE 781

  Fly   762 ELGNNTLRMNFQSATTDHASVFIQPLEDVIISNWSLPTSYIGQQDTS-----HMYFSYGKNNTAL 821
            :...:::::.|::....|.|.:::..:...:|.|||..   |...||     .:::|:|...:|.
Human   782 QTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGN---GTPVTSKGGDYFVFYSHGLQASAW 843

  Fly   822 TFFIDFYKLDADFAVPLCQIGLAVHFIGNKG------DAISQEFAKKIPSFAAAVDWPASYQRYI 880
            .|:|: .::..:....:..:.:|.|::..:.      ||:.::|    |.:.....|..:|..::
Human   844 QFWIE-VQVSEEHPEGMVTVAIAAHYLSGEDKRSPQLDALKEKF----PDWTFPSAWVCTYDLFV 903

  Fly   881 F 881
            |
Human   904 F 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	140/311 (45%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	63/288 (22%)
ERMP1	NP_079172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
ERMP1	NP_079172.2	M28_Fxna_like	104..412	CDD:193497	140/311 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145824
Domainoid	1	1.000	238	1.000	Domainoid score	I2299
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1816
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm40549
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770