DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10073 and Folh1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_058050.3	Gene:	Folh1 / 53320	MGIID:	1858193	Length:	752	Species:	Mus musculus

Alignment Length:	337	Identity:	68/337 - (20%)
Similarity:	107/337 - (31%)	Gaps:	109/337 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWQAVRSRFDTCKNKISDEPIEDAVRSASSKKIKNQEQYLR-GPWYLA------TGFLLFWALLF 58
            ||.|::.|                   .|::.:.:::::|| |...||      .|||..|.:..
Mouse     1 MWNALQDR-------------------DSAEVLGHRQRWLRVGTLVLALTGTFLIGFLFGWFIKP 46

  Fly    59 SAVVLPLFYRIPTGLTIEDASKGVFIAERAQSNLYKLAEIGTK---VVGSDNNENKTVDYLMGLV 120
            |        ...||.......|..|:.|....|:.|.....|:   :.|:.||
Mouse    47 S--------NEATGNVSHSGMKKEFLHELKAENIKKFLYNFTRTPHLAGTQNN------------ 91

  Fly   121 NEIQENCLDDYFDIEVDLQEVSGSYIHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLV-----NSH 180
            .|:.:...|.:.:..:||.|:|    |:.::            ||..|.|...|:.:     |..
Mouse    92 FELAKQIHDQWKEFGLDLVELS----HYDVL------------LSYPNKTHPNYISIINEDGNEI 140

  Fly   181 F----------------DSKPT----SPSAGDAGQMVVA----------ILEVLRVMCSTKQAI- 214
            |                |..|.    ||.....|.:|..          :...:::.||.|..|
Mouse   141 FKTSLSEQPPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLEREMKISCSGKIVIA 205

  Fly   215 RHPVVFLLNGAEENPLQASHGFITQHKWA-------KNCKVVLNLDAAGNGGSDIVFQTGPNSPW 272
            |:..||..|..:...|..:.|.|.....|       |:.....||...|....:::...|...|
Mouse   206 RYGKVFRGNMVKNAQLAGAKGMILYSDPADYFVPAVKSYPDGWNLPGGGVQRGNVLNLNGAGDP- 269

  Fly   273 LVEKYKENAPHY 284
            |...|..|...|
Mouse   270 LTPGYPANEHAY 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	51/251 (20%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401
Folh1	NP_058050.3	Zinc_peptidase_like	70..>116	CDD:301362	13/61 (21%)
		PA_GCPII_like	122..348	CDD:239036	33/161 (20%)
		NAALADase	276..589		2/6 (33%)
		M28_PSMA_like	356..597	CDD:193568
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Q0	519..520
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q04609	536..538
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Q0	554..555
		TFR_dimer	634..749	CDD:282153
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9Y3Q0	701..702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900