DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and Ermp1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_006231303.1	Gene:	Ermp1 / 373544	RGDID:	727831	Length:	899	Species:	Rattus norvegicus

Alignment Length:	909	Identity:	277/909 - (30%)
Similarity:	430/909 - (47%)	Gaps:	158/909 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLFWALLFSAVVLPLFYRIPTGLTIEDASKGVFIAERAQSNLYKLAEIGTKVVGSDNNENKTVDY 115
            |..:.|...|:|.....|:....|  ...:|.|.|.:|:..|..:..||.:..||..||..||.|
  Rat    71 LALYLLALRALVQLSLQRLVLSRT--SGLQGEFDARQARVYLEHITAIGPRTTGSAENEILTVQY 133

  Fly   116 LMGLVNEIQENCLDDYFDIEVDLQEVSGSY-IHWT--MVNMYQGVQNIVIKLSPKNTTSTTYLLV 177
            |:..:..|:|.. :....|.||:|..:||: |.:.  ..:.|..:.|:|:||.|::..... :|.
  Rat   134 LLEQITLIEEQS-NSLHRISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPQDGAKYA-VLA 196

  Fly   178 NSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQAIRHPVVFLLNGAEENPLQASHGFITQHKW 242
            |.||||...||.|.|.......:|||||||.::.:.::|.||||.||||||.|||||||||||.|
  Rat   197 NCHFDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPW 261

  Fly   243 AKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDFAI 307
            |...:..:||:|||.||.::||||||.:||||:.|...|.|..|:.:|:|:||:||:||||||.|
  Rat   262 ASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRI 326

  Fly   308 FVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGSIQNTGDNLLGLVRSIANSTELDNTEAYATG 372
            :..:||:.|:|:|...||:.||||||....|...|||..|||:|.:::.:|.|..|.::..|..|
  Rat   327 YRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKYLATSDMLASSSEYRHG 391

  Fly   373 HAIFFDVLGLYFISYTESNGVILNYSVAGVALVLIFLSIWRTSSISRVSIGHVLCWFILIFVLQI 437
            ..:|||||||..|:|....|.|:||.|                                     :
  Rat   392 SMVFFDVLGLLVIAYPSRVGSIINYMV-------------------------------------V 419

  Fly   438 IAFVLGLGLPIV------VAYVFD-KYGLSITYFS-----TPVLLIGLYICPSLLGLSLPSYIYL 490
            :|.||.||..::      ..||.| ..||.||:.|     ..||:|.:::  ||:|.||..|.|.
  Rat   420 MAVVLYLGRKLLRPKHRNSNYVRDFLCGLGITFISWFTSLVTVLIIAVFV--SLIGQSLSWYNYF 482

  Fly   491 KLQRSEKVGFAQHLQLVLHGHAAVLAILDI----------------------------------G 521
                        ::.:.|:|.|.|..|:.|                                  .
  Rat   483 ------------YIAVCLYGTATVAKIILIHTLAKRFYYVNASDLYLGELFFDTSLFVHCGFLVA 535

  Fly   522 LTVYGLRSAYV-PTWTLIFYVIPLAVNLLTTL--------HDRGFSWTGVLKIFQVVPFLYNSYL 577
            ||..|..||:: ..|        :|..|||.|        |.....:..:..:...:|:||..||
  Rat   536 LTAQGFCSAFMSAVW--------VAFPLLTKLCVYKDFKKHGAKGRFIALYLLGMFIPYLYGLYL 592

  Fly   578 IYCFVVTLIPMMGRFGRATNPDLIISALCALGTILALGFVIPLVNMFRRPSLILLTLLAISAVTI 642
            |:.......|::||.|....||::::::.|:..::...:.|..:.:.......:|||:.:.|||.
  Rat   593 IWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTF 657

  Fly   643 YTASSTQIGFPY-------RPKTNVQRLPYLHVRRIFYEYDGTVVKNDSGYLFNFQDRRGPAPL- 699
            ....|... |||       :||    |:...||.|.|:..:|:|||.|||...|..|..|.:.:
  Rat   658 LLVCSGAF-FPYSSNPDSPKPK----RVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVT 717

  Fly   700 -KLSKLNTTGLVSIAADC-DTVMMCGFPLY--DHRWVKNRLQIMWLPREEEIITPYEP-KLELLS 759
             .:.::|.|    |.|.| :...:||||.|  .|..::..   .:||..|  |:|..| ...|:|
  Rat   718 PHIPEINDT----IRAHCEENAPLCGFPWYLPVHFLIRKN---WYLPAPE--ISPRNPAHFRLVS 773

  Fly   760 KTELGNNTLRMNFQSATTDHASVFIQPLEDVIISNWSLPTSYIGQQDTSH-----MYFSYGKNNT 819
            |.::..:::::.|::....|.|.:::..:...:|.|||..   |...||.     :::|:|...:
  Rat   774 KEKMPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGN---GIPVTSRGGDYFVFYSHGLQAS 835

  Fly   820 ALTFFIDFYKLDADFAVPLCQIGLAVHFIGNKGDAISQ--EFAKKIPSFAAAVDWPASYQRYIF 881
            |..|:|:..::..:....:..:.:|.|::..:....||  ...:|.|.::....|.::|..::|
  Rat   836 AWQFWIEVQQVSEEQPEGMVTVAIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	139/309 (45%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	59/294 (20%)
Ermp1	XP_006231303.1	M28_Fxna_like	99..406	CDD:193497	139/308 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339533
Domainoid	1	1.000	242	1.000	Domainoid score	I2158
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1759
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm44686
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770