DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and CG13160

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001260918.1	Gene:	CG13160 / 36343	FlyBaseID:	FBgn0033720	Length:	875	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	396/872 - (45%)
Similarity:	573/872 - (65%)	Gaps:	31/872 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EDAVRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLPLFYRIPTGLTI-EDASK-GVFI 84
            ||.:|.         :||   .||.|..:||||..||.||:.|||..:|||:.| |:|.| |.|:
  Fly    23 EDKIRC---------KQY---SWYFAPIYLLFWVGLFFAVIYPLFQALPTGIKISEEADKPGQFV 75

  Fly    85 AERAQSNLYKLAEIGTKVVGSDNNENKTVDYLMGLVNEIQENCLDDYFDIEVDLQEVSGSYIHWT 149
            |||||..|.:::.:|.:|||..:||...|:.|:..:.::::...||.:::||::|..||||:...
  Fly    76 AERAQEILLQISRLGPRVVGDVDNEVTVVNLLLAEIEKVRQVLRDDVYEMEVEVQRASGSYLIKG 140

  Fly   150 MVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQAI 214
            :.|.||||||::::||.|::.||:|||||||:|:||.||.|||...|||.:|||||::..:....
  Fly   141 LTNHYQGVQNVIVRLSTKSSNSTSYLLVNSHYDTKPGSPGAGDDAAMVVVMLEVLRLVAVSGDPF 205

  Fly   215 RHPVVFLLNGAEENPLQASHGFITQHKWAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKE 279
            .||::||.|||||.|:|.||||||||:||.|||.:||||:||.||.|::||.|||.|||:|.|:.
  Fly   206 LHPIIFLFNGAEEQPMQGSHGFITQHRWAANCKALLNLDSAGAGGRDLLFQGGPNHPWLMEHYRN 270

  Fly   280 NAPHYLATTMAEEIFQTGILPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGSIQ 344
            :|||..|||.|||:|:.||:||||||.||..:|.:.|||||...|||.||||:|:::.|...|:|
  Fly   271 SAPHPFATTTAEEMFEAGIIPSDTDFRIFRDFGVVPGLDMAGVYNGFVYHTKFDRYAVISLDSLQ 335

  Fly   345 NTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTESNGVILNYSVAGVALVLIFL 409
            |:|||||.||.||:|:.|:.:|||:|.|||:|||.:||:|:.|.||..:.||...:..|::|:.:
  Fly   336 NSGDNLLALVWSISNAEEMYDTEAHAAGHAVFFDFIGLFFVHYQESTSLALNLFFSFGAILLVCI 400

  Fly   410 SIWRTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLPIVVAYVFDKYGLSITYFSTPVLLIGLY 474
            |:||.|.::..::|.....|.|:|:|.:...:|.:..|:::|..:|....::||||...|:||||
  Fly   401 SLWRMSRVTGQTMGTYAGVFGLLFLLALAGALLAVAFPLLMATFYDWGNRTLTYFSNSWLVIGLY 465

  Fly   475 ICPSLLGLSLPSYIYLKLQRSEKVGFAQHLQLVLHGHAAVLAILDIGLTVYGLRSAYVPTWTLIF 539
            ||||::||.||..:||...:..|:....:|.:|.|.:..:||||.:|.|....||||:...:|||
  Fly   466 ICPSVIGLVLPMTLYLTHTKCNKIPHTYYLHIVGHANCVLLAILCLGATALKYRSAYLFLISLIF 530

  Fly   540 YVIPLAVNLLTTLHDRGFSWTGVLKIFQVVPFLYNSYLIYCFVVTLIPMMGRFGRATNPDLIISA 604
            ||..|.:||||.||.||:.|:.||.:||::||:|::||.:.|::.||||.||||.:||||::|.|
  Fly   531 YVAALIINLLTRLHCRGYLWSLVLIVFQIIPFIYHAYLFHMFILILIPMTGRFGVSTNPDILIGA 595

  Fly   605 LCALGTILALGFVIPLVNMFRRPSLILLTLLAISAVTIYTASSTQIGFPYRPKTNVQRLPYLHVR 669
            ||..||||||.|..||:|:||||:.:|..|..:..:....|.| .:||||||||||.|..::.|.
  Fly   596 LCGFGTILALSFAAPLINVFRRPNCMLGGLALVMFIFCMIAVS-DVGFPYRPKTNVMRADFMQVH 659

  Fly   670 RIFYEYDGTVVKNDSGYLFNFQDRRGPAPLKLSKLNTTGLVSIAADCDTVMMCGFPLYDHRWVKN 734
            |.|:||:|::...||||.|:..||...|||: ..:|.|.||.:..|||:.:|||.|.|  |:...
  Fly   660 RKFFEYNGSISHEDSGYYFHLGDRNKEAPLR-DHMNLTNLVRLGEDCDSELMCGIPCY--RYCSA 721

  Fly   735 RLQIMWLPREEEIITPYEPKLELLSKTEL-GNNTLRMNFQSATTDHASVFIQPLEDVIISNWSL- 797
            |...:||.|||.:..||...||.||||.| |...:|..|:.....:..:|.:||:.|.:..|:.
  Fly   722 REHALWLAREEPVELPYPTVLEFLSKTVLSGGYQVRYEFRLTGPPNMGLFFKPLDGVKLLRWTFA 786

  Fly   798 ------PTSYIGQQDTSHMYFSYGKNNTALTFFIDFYKLDADFAVPLCQIGLAVHFIG--NKGDA 854
                  |.:|   :....:..:||.:||.:.||::..|.|.:|..|:.::|::.|::.  :|.||
  Fly   787 PAMLDNPATY---RPPLEVMLTYGIDNTPIEFFVELSKDDGNFNEPVFEMGVSGHYVSPHDKRDA 848

  Fly   855 ISQEFAKKIPSFAAAVDWPASYQRYIF 881
            :|.||...:|.||.:::||:||:|:||
  Fly   849 LSLEFLATLPDFAFSMEWPSSYERHIF 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	166/307 (54%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	105/239 (44%)
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:193497	165/306 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446894
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800