DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and CG30049

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_725142.3	Gene:	CG30049 / 246416	FlyBaseID:	FBgn0050049	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	881	Identity:	405/881 - (45%)
Similarity:	571/881 - (64%)	Gaps:	17/881 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DTCKNKISDEPIEDAVRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLPLFYRIPTGLT 74
            |..|...||..:...:  :..||:|.     |.|||.|..|||.|..||.|:|||||||:|..:|
  Fly     6 DGDKEGFSDTALYHVL--SKEKKLKR-----RLPWYYAPSFLLLWVALFYAIVLPLFYRLPDRVT 63

  Fly    75 IED--ASKGVFIAERAQSNLYKLAEIGTKVVGSDNNENKTVDYLMGLVNEIQENCLDDYFDIEVD 137
            :.|  ...|.|:.||||..||:|..||.|||||..||..||.:|:..|.:|:.....|.|.:|||
  Fly    64 MADEPLKPGQFVGERAQKILYELDRIGPKVVGSTANEVTTVAFLLNEVEKIRSEMRGDLFHLEVD 128

  Fly   138 LQEVSGSYIHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSKPTSPSAGDAGQMVVAILE 202
            :|:.:|||:..||.::|||:||:|:|||..::.|::|||:|||||:||.||.|||.|.|||.:||
  Fly   129 VQQPTGSYVVGTMTSIYQGIQNVVVKLSTASSNSSSYLLINSHFDTKPGSPGAGDDGTMVVVMLE 193

  Fly   203 VLRVMCSTKQAIRHPVVFLLNGAEENPLQASHGFITQHKWAKNCKVVLNLDAAGNGGSDIVFQTG 267
            |||.|..::....||:|||.|||||||||||||||||||||.|||.|:||:..||||.||:||:|
  Fly   194 VLRQMSISESEFMHPIVFLFNGAEENPLQASHGFITQHKWAPNCKAVINLEVGGNGGRDILFQSG 258

  Fly   268 PNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKY 332
            ||:||||:.||:::.|..|:|:||||||.|||||||||.||..|||:.|||:|:|.||:.|||.:
  Fly   259 PNNPWLVKYYKQHSKHPFASTLAEEIFQFGILPSDTDFRIFRDYGNIPGLDIAQFSNGYVYHTAF 323

  Fly   333 DQFSNIPRGSIQNTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTESNGVILNY 397
            |.|..:|..::||||:|:|.|||:::|::||.||..::.|||:|||.|||:|::|||:.|:||||
  Fly   324 DSFDVVPGRAVQNTGENILSLVRALSNASELYNTNEHSAGHAVFFDFLGLFFVTYTENTGIILNY 388

  Fly   398 SVAGVALVLIFLSIWRTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLPIVVAYVFDKYGLSIT 462
            ..|..::.|:..|:||.|.:|.||.|.:...|.....|.:...:|.:|||:|::.::|....::|
  Fly   389 CFAVASVFLVGFSLWRMSCVSEVSAGRISILFASHLGLHLAGCLLCIGLPLVMSILYDVSDRTMT 453

  Fly   463 YFSTPVLLIGLYICPSLLGLSLPSYIYLKLQRSEKVGFAQHLQLVLHGHAAVLAILDIGLTVYGL 527
            |:|...|:|||||||:::||.|||.:|...:..:|:.....:.:.||.|..||:||.|.||..||
  Fly   454 YYSNNWLVIGLYICPAIIGLVLPSTLYHSFKSDDKISHPYQMYVGLHAHCVVLSILTIALTAIGL 518

  Fly   528 RSAYVPTWTLIFYVIPLAVNLLTTLHDRGFSWTGVLKIFQVVPFLYNSYLIYCFVVTLIPMMGRF 592
            |..|:...:|..|::.|.:||||||||||:.|...::|.|:..::|..||.|.|:|...|.|||.
  Fly   519 RIPYMCMISLFLYILSLLINLLTTLHDRGYYWVLTVQISQLFQYVYFCYLFYIFLVIFFPAMGRN 583

  Fly   593 GRATNPDLIISALCALGTILALGFVIPLVNMFRRPSLILLTLLAISAVTIYTASSTQIGFPYRPK 657
            ..:.|||::|:.:||:||..|||||:||:||||. |..||..|.:....:...|.|.:|||||||
  Fly   584 RDSANPDMLIALICAVGTFFALGFVVPLINMFRW-STYLLICLGVVTFILSMISITGVGFPYRPK 647

  Fly   658 TNVQRLPYLHVRRIFYEYDGTVVKNDSGYLFNFQDRRGPAPLKLSKLNTTGLVSIAADCDTVMMC 722
            |:|.|:.:|..||:||||||::..|||||.|::||||...|||...:|.|||.|:...||..:||
  Fly   648 TSVMRVNFLQTRRMFYEYDGSLSVNDSGYYFDYQDRRALRPLKDYAVNLTGLTSVDGYCDRYVMC 712

  Fly   723 GFPLYDHRWVKNRLQIMWLPREEEIITPYEPKLELLSKT-ELGNNTLRMNFQSATTDHASVFIQP 786
            |.|.:...|.:......||||:||:..|...:|..|:|| ....::.|..|:.|...|..::|:|
  Fly   713 GIPCFWSSWCRGISSAAWLPRDEEVTVPGNLELNFLNKTLSKSGSSARFEFELAGPPHMGLYIRP 777

  Fly   787 LEDVIISNWSLPTSYIGQQD----TSHMYFSYGKNNTALTFFIDFYKLDADFAVPLCQIGLAVHF 847
            |:.|.:.:||...:.:.|.:    ...:|||||.:::...|.|:|.|.|.....|:.::|:..|:
  Fly   778 LDGVAVEDWSFIRTMLDQPEKYSPPYQIYFSYGVDSSPFKFHIEFVKSDGQLDGPIFELGVVGHY 842

  Fly   848 IGN--KGDAISQEFAKKIPSFAAAVDWPASYQRYIF 881
            :..  :.|..:..|...:|.|...::||:.:.||||
  Fly   843 VNQDFERDETTLRFIADLPDFVYTMEWPSLFMRYIF 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	178/306 (58%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	99/239 (41%)
CG30049	NP_725142.3	M28_Fxna_like	71..378	CDD:193497	178/306 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446895
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800