DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10073 and FOLH1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_016872921.1	Gene:	FOLH1 / 2346	HGNCID:	3788	Length:	805	Species:	Homo sapiens

Alignment Length:	351	Identity:	60/351 - (17%)
Similarity:	116/351 - (33%)	Gaps:	120/351 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 YFDIEVDLQEVSGS--------------------------------YIHWT--MVNMYQGVQNIV 161
            |:|.:..|:::.||                                :||.|  :..:|..:..:.
Human   354 YYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLR 418

  Fly   162 IKLSPKNTTSTTYLLVNSHFDS---KPTSPSAGDAGQMVVAILEVLRVMCSTKQ---AIRHPVVF 220
            ..:.|..     |:::..|.||   ....|.:|.|     .:.|::|...:.|:   ..|..::|
Human   419 GAVEPDR-----YVILGGHRDSWVFGGIDPQSGAA-----VVHEIVRSFGTLKKEGWRPRRTILF 473

  Fly   221 LLNGAEENPLQASHGFITQHKWA-KNCKVV-------LNLDAAGNGGSDIVFQTGPNSPWLVEKY 277
            ....|||      .|.:...:|| :|.:::       :|.|::..|...:.....|....||
Human   474 ASWDAEE------FGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLV--- 529

  Fly   278 KENAPHYLATTMAEEIFQTGILPSDTDFAIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGS 342
                 |.|...:..        |.:             |.:.......:...:...:||.:||.|
Human   530 -----HNLTKELKS--------PDE-------------GFEGKSLYESWTKKSPSPEFSGMPRIS 568

  Fly   343 IQNTGDNL------LGLVRSIANST---ELDNTEAYATGHAI---------FFDVLGLYFISYTE 389
            ...:|::.      ||:....|..|   |.:....|...|::         |:|.:..|.::..:
Human   569 KLGSGNDFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQ 633

  Fly   390 ---------SNGVILNYSVAGVALVL 406
                     :|.::|.:.....|:||
Human   634 VRGGMVFELANSIVLPFDCRDYAVVL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	55/321 (17%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	3/9 (33%)
FOLH1	XP_016872921.1	Zinc_peptidase_like	113..>169	CDD:301362
		PA_GCPII_like	175..401	CDD:239036	5/46 (11%)
		M28_PSMA_like	403..650	CDD:193568	50/291 (17%)
		TFR_dimer	687..802	CDD:282153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900