DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and Ermp1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_001349060.1	Gene:	Ermp1 / 226090	MGIID:	106250	Length:	899	Species:	Mus musculus

Alignment Length:	906	Identity:	278/906 - (30%)
Similarity:	432/906 - (47%)	Gaps:	152/906 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LLFWALLFSAVVLPLFYRIPTGLTIEDASKGVFIAERAQSNLYKLAEIGTKVVGSDNNENKTVDY 115
            |..:.|...|:|.....|:....|  ...:|.|.|.:|:..|..:..||.:..||..||..||.|
Mouse    71 LALYLLALRALVQLSLQRLVLSRT--SGLQGEFDARQARDYLEHITAIGPRTTGSTENEILTVQY 133

  Fly   116 LMGLVN--EIQENCLDDYFDIEVDLQEVSGSY-IHWT--MVNMYQGVQNIVIKLSPKNTTSTTYL 175
            |:..:.  |.|.|.|   ..|.||:|..:||: |.:.  ..:.|..:.|:|:||.|::...:. :
Mouse   134 LLEQIKLIEAQSNSL---HSISVDIQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGAESA-I 194

  Fly   176 LVNSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQAIRHPVVFLLNGAEENPLQASHGFITQH 240
            |.|.||||...||.|.|.......:|||||||.::.:.::|.||||.||||||.|||||||||||
Mouse   195 LANCHFDSVANSPGASDDAVSCAVMLEVLRVMSASPEPMQHAVVFLFNGAEENVLQASHGFITQH 259

  Fly   241 KWAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDF 305
            .||...:..:||:|||.||.::||||||.:||||:.|...|.|..|:.:|:|:||:||:||||||
Mouse   260 PWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDF 324

  Fly   306 AIFVKYGNLIGLDMAKFINGFAYHTKYDQFSNIPRGSIQNTGDNLLGLVRSIANSTELDNTEAYA 370
            .|:..:||:.|:|:|...||:.||||||....|...|||..|||:|.:::.:|.|..|.::..|.
Mouse   325 RIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKHLATSDTLASSSEYR 389

  Fly   371 TGHAIFFDVLGLYFISYTESNGVILNYSVAGVALVLIFLSIWRTSSISRVSIGHVLCWFILIFVL 435
            .|..:|||||||..|:|....|.|:||.|
Mouse   390 HGSMVFFDVLGLLVIAYPSRVGSIINYMV------------------------------------ 418

  Fly   436 QIIAFVLGLGLPIV------VAYVFD-KYGLSITYFS-----TPVLLIGLYICPSLLGLSLPSYI 488
             ::|.||.||..::      ..|:.| ..||.||:.|     ..||:|.::|  ||:|.||..|.
Mouse   419 -VMAVVLYLGKKLLRPKHRNANYMRDFLCGLGITFISWFTSLVTVLIIAVFI--SLIGQSLSWYN 480

  Fly   489 YLKLQRSEKVGFAQHLQLVLHGHAAVLAILDI--------------------------------- 520
            |.            ::.:.|:|.|.|..|:.|
Mouse   481 YF------------YIAVCLYGTATVAKIIFIHTLAKRFYYMNASDLYLGELFFDTSLFVHCAFL 533

  Fly   521 -GLTVYGLRSAYVPTWTLIFYVIPLAVNLLT----TLHDRGFSWTGVLKIFQVVPFLYNSYLIYC 580
             .||..|..||::   :.::.|.||...|..    ..|.....:..:..:...:|:||..|||:.
Mouse   534 VALTYQGFCSAFM---SAVWVVFPLLTKLCVYKDFKKHGAQGRFVALYLLGMFIPYLYGLYLIWA 595

  Fly   581 FVVTLIPMMGRFGRATNPDLIISALCALGTILALGFVIPLVNMFRRPSLILLTLLAISAVTIYTA 645
            ......|::||.|....||::::::.|:..::...:.|..:.:.......:|||:.:.|||....
Mouse   596 VFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLV 660

  Fly   646 SSTQIGFPY-------RPKTNVQRLPYLHVRRIFYEYDGTVVKNDSGYLFNFQDRRGPAPL--KL 701
            .|... |||       :||    |:...||.|.|:..:|:|||.|||...|..|..|.:.:  .:
Mouse   661 CSGAF-FPYSSNPESPKPK----RVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHI 720

  Fly   702 SKLNTTGLVSIAADC-DTVMMCGFPLY--DHRWVKNRLQIMWLPREEEIITPYEP-KLELLSKTE 762
            .::|.|    |.|.| :...:||||.|  .|..::..   .:||..|  ::|..| ...|:||.:
Mouse   721 PEINDT----IRAHCEEDAPLCGFPWYLPVHFLIRKN---WYLPAPE--VSPRNPAHFRLVSKEK 776

  Fly   763 LGNNTLRMNFQSATTDHASVFIQPLEDVIISNWSLPTSYIGQQDTSH-----MYFSYGKNNTALT 822
            :..:::::.|::....|.|.:::..:...:|.|||..   |...||.     :::|:|...:|..
Mouse   777 MPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGN---GIPVTSRGGDYFVFYSHGLQASAWR 838

  Fly   823 FFIDFYKLDADFAVPLCQIGLAVHFIGNKGDAISQ--EFAKKIPSFAAAVDWPASYQRYIF 881
            |:|:..::..:.|..:..:.:|.|::..:....||  ...||.|.::....|.::|..::|
Mouse   839 FWIEVQQVSEEQAEGMVTVAIAAHYLSGENKRSSQLDALKKKFPDWSFPSAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	141/311 (45%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	57/289 (20%)
Ermp1	NP_001349060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
Ermp1	NP_001349060.1	M28_Fxna_like	99..406	CDD:193497	141/310 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835896
Domainoid	1	1.000	247	1.000	Domainoid score	I2148
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm42620
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760