DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and gcp-2.2

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_509928.3	Gene:	gcp-2.2 / 183230	WormBaseID:	WBGene00007954	Length:	779	Species:	Caenorhabditis elegans

Alignment Length:	985	Identity:	184/985 - (18%)
Similarity:	308/985 - (31%)	Gaps:	357/985 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RSRFD---TCK---NKISDEPIEDAVRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLP 64
            |:||.   :|.   |...|:..:.:.|:...|               |:|.:|   :..|.|.|.
Worm     5 RNRFTQGCSCMKYYNNNGDKVFQKSKRNRGMK---------------ASGVVL---VAVSTVALT 51

  Fly    65 LF--------YR-----IPTGLTIEDASKGVFIAERAQSNLYKLAEIGTK---VVGSDNNENKTV 113
            :.        |:     :|. |:|....|.:...:..:|||:.|    ||   |.|::||
Worm    52 IILSNAIHQSYKSNSKPLPK-LSIATNIKQLINVDNIRSNLHSL----TKKPHVAGTENN----- 106

  Fly   114 DYLMGLVNEIQENCLDDYFD-IEVDLQEVSGSYIHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLV 177
               :.:...|::..:....: :..:...|..||.:||..|:.:     ::|.:.....|||
Worm   107 ---LRVAEMIRDQMITQGLENVHFNEYNVMLSYPNWTTPNIIE-----ILKENRDLVFSTT---- 159

  Fly   178 NSHFDSKPTSPSAGDAGQMVVAILEVLRVMCSTKQAIRHPVVFLLNGAEEN-PLQASHGFITQHK 241
                            |:.|..|.|                       |:| ||       .:.:
Worm   160 ----------------GRSVSVIKE-----------------------EQNDPL-------AEIQ 178

  Fly   242 WAKNCKVVLNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDFA 306
            |       |...|||....|||:....| |..:| |.|:    |...:.::||
Worm   179 W-------LAYSAAGTVEGDIVYVNNAN-PSDIE-YLES----LGIDLKDKIF------------ 218

  Fly   307 IFVKY-----GNLIGLDMAKFIN--------------GFAYHTKYDQFSNIPRGSIQ------NT 346
             ..:|     ||:..:.:.|...              |...:..|.....:|..::|      ..
Worm   219 -LARYSSNYRGNIAQMAVKKGAKACLVYSDPKQVASLGTGPNETYGNTDKMPSNTVQMGSVYIGL 282

  Fly   347 GDNLLGLVRSIAN----STELDNTE------------AYAT---------GHAIFFDVLGLYFIS 386
            ||.......||.:    .||.|..:            .|||         |.|:..|..|...::
Worm   283 GDPRTPAFPSIGDLFKEKTEQDLLDEKKIPTIPMLPITYATAQILFENMKGDAVNADFQGKLNVT 347

  Fly   387 YTESNGVILNYSVAGVALVLIFLSIWRTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLP---I 448
            |....|:|.|..:.        :::...:...::.              .|:.::.|...|   :
Worm   348 YRYGPGLINNQKLR--------VTVHAENEERKIQ--------------NIMGYIKGSQEPDKFV 390

  Fly   449 VVAYVFD--KYGLSITYFSTPVLL------------IGLYICPSLLGLSLPSYIYLKLQRSEKVG 499
            :|:..:|  .||.......|..||            .|.....|:|.....:..|..:..:|
Worm   391 LVSNHYDAWTYGAVDPNSGTSTLLEVSRALKQYQNQTGWIPARSILFAHWDAEEYGLIGSTE--- 452

  Fly   500 FAQHLQLVLHGHAAVLAILDI---GLTVYGLRSAYVPTWTLIFYVIPLAVNLLTTLHDRGFSWTG 561
            ||:..:|.|...|..:..:|:   ..|:.||.:             |...|:|.         :.
Worm   453 FAEEYRLQLMRRAVAVINMDLIGGNQTLLGLSN-------------PTVANVLR---------SA 495

  Fly   562 VLKIFQVVP--------FLYNSYLIYCFVVTLIPMMGRFGRATNPDLIISALCALGTILALGFVI 618
            ...:.|..|        .||:|:..|.        ..:..|:|:|...|.|        .....:
Worm   496 AANVEQPNPTEMEQGRKTLYDSWKYYA--------PSKNNRSTHPYQRIPA--------GGSDHL 544

  Fly   619 PLVNMFRRPSLILLTLLAISAVTIYTASSTQIGFPYRPKTNVQRLPY-LH--VRRIFYE------ 674
            |..:....|.:..:| .::.|...|....|....||..: |:....| :|  :..:|.|
Worm   545 PFFDYLGIPIVFFIT-SSLDAPPTYPLYHTIYETPYLIE-NIMDPGYKVHKAIAGMFIECILKFT 607

  Fly   675 ------YDGTVVKNDS--GYLFNFQDRRGPAPLKLSKLNTTGLVSIAADCDTVMMCGFPLYDHRW 731
                  ||...:.:||  .||...:||          ||.|.::....|.         |.|.:.
Worm   608 ESKILPYDLNELMDDSIFEYLPKLEDR----------LNKTLMIGTKTDY---------LLDAQK 653

  Fly   732 VKNRLQIMWLPREEEIITPYEPKLELL---SKTELGNNTLRMNFQSATTDHASVFIQPLEDVIIS 793
            ....||...|...|.:......|||.|   |:.::.|..:         :....||.
Worm   654 QFKLLQKTVLELSEIVQRRNVSKLEELPFGSRVDINNRLI---------EFEKCFIN-------- 701

  Fly   794 NWSLPTSYIGQQDTSHMYFSYGKNNTALTFFIDFYKLDADFAVPLCQIGLAVHFIGNKGDA---- 854
                |...||.....|:.|....:|        :|..||     :.|:...:..|.|..|:
Worm   702 ----PHGAIGNPQARHVLFHPSPDN--------WYDGDA-----ISQVHDLISKISNSTDSKELG 749

  Fly   855 -ISQEFAKKI 863
             :|::.||:|
Worm   750 KLSRQLAKEI 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	68/361 (19%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	41/267 (15%)
gcp-2.2	NP_509928.3	Zinc_peptidase_like	75..>133	CDD:301362	12/69 (17%)
		PA_GCPII_like	137..364	CDD:239036	57/315 (18%)
		M28_PSMA_like	372..614	CDD:193568	51/298 (17%)
		TFR_dimer	652..773	CDD:282153	29/142 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900