DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10073 and B0495.7

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_495618.1	Gene:	B0495.7 / 174245	WormBaseID:	WBGene00015206	Length:	895	Species:	Caenorhabditis elegans

Alignment Length:	867	Identity:	264/867 - (30%)
Similarity:	430/867 - (49%)	Gaps:	125/867 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VRSRFDTCKNKISDEPIEDAVRSASSKKIKNQEQYLRGPWYLATGFLLFWALLFSAVVLPLFYRI 69
            :|...:..||:..|:  :...|...|...::        |..   |:|..|::::.|| .|..::
Worm    11 LRDELNNSKNQPEDD--QRTKRGRESIGFRH--------WIY---FVLTVAIVYAGVV-ALHRKM 61

  Fly    70 PT---GLTIEDASKGVFIAERAQSNLYKLAEIGTKVVGSDNNENKT-------VDYLMGLVNEIQ 124
            |.   |.:.||     |..:||:..|.:|..:|::..||||.|.|.       :..:..:|:|:.
Worm    62 PAVRDGTSFED-----FSEQRARVLLKQLTALGSRPSGSDNLEVKAFGMIQDRIGKIHSVVDEVG 121

  Fly   125 ENCLDDYFDIEVDLQEVSGSY-----IHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDSK 184
            .|.|      |.|:|..||.:     ..:|:  .|..:.|:|:::.||...|...||:|.|||:.
Worm   122 VNRL------ESDVQRPSGCFDLKFLSSFTL--CYHKITNVVVRIGPKKGPSGNSLLLNCHFDTM 178

  Fly   185 PTSPSAGDAGQMVVAILEVLRVMCSTKQAIRHPVVFLLNGAEENPLQASHGFITQHKWAKNCKVV 249
            |.:|.|.|.......:::||.|:..:|..:.:.||||.||||||.|||:||||.||.|..:.:..
Worm   179 PDTPGATDDAVACTIMMDVLEVLAHSKTELENDVVFLFNGAEENFLQAAHGFINQHPWRHDIRAF 243

  Fly   250 LNLDAAGNGGSDIVFQTGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDFAIFVKYGNL 314
            :||:..|:||.:|:||.||.:.||::.|.|||||...:.:|:||||:||:||||||.||..||.:
Worm   244 INLEGTGSGGREILFQAGPGNSWLLQTYLENAPHPFCSVLAQEIFQSGIIPSDTDFRIFRDYGRI 308

  Fly   315 IGLDMAKFINGFAYHTKYDQFSNIPRGSIQNTGDNLLGLVRSIANSTELDNTEAY-ATGHAIFFD 378
            .|||:|...||:.|||::|:...|..|:||..|:|:|.:||:|..|..|:....: .....:|:|
Worm   309 SGLDIAYTKNGWFYHTEFDEEWRIEPGAIQRAGENVLAVVRAILKSPYLEKPATFDEENRWVFYD 373

  Fly   379 VLGLYFISYTESNGVILNYSVAGVALVLIFLSIW-RTSSISRVSIG---HVLCWF-ILIFVLQII 438
            |:||:.:.|:.:.|.:|||........|:.|.|. |..|:..::|.   ||:.:. ::|.:|.||
Worm   374 VVGLFTVYYSVNVGKLLNYIACFATYFLVVLRIRNRLYSVGDLAIAFKHHVVAFLAMVITMLLII 438

  Fly   439 AFVLGLGLPIVVAYVFDKYGLSITYFSTPVLLIGLYICPSLLGLSLPSYIYLKLQRSEKVGFAQH 503
            |||:             :..|.:.::..|.::..||:.|.|:..::....|....|...|...|:
Worm   439 AFVV-------------QMDLVMCWYKMPEIVGALYVLPMLIAGAIVHSHYADNNRIRNVEMVQY 490

  Fly   504 LQLVLHGHAAVLAILDIGLTVYGLRSAYVPTWTLIFYVIPLAVNLLTTLHDRGFSWT----GVLK 564
             ..:|...|::|.:    :|.|.|.||        |||:.   ||:..:......|.    ||::
Worm   491 -DTILLSFASILFL----MTFYNLSSA--------FYVLN---NLILPVFKDIIIWALGLFGVIR 539

  Fly   565 -----------IFQVVP-FLYNSYLIYCFVVTLIPMMGRFGRATNPDLIISALCALGTILALGFV 617
                       :|..:| |::.:|.|...|...:|:|||.|.|.||:.|:.   .||.::|.||:
Worm   540 RVTPRVLFFTQLFCFLPTFVFAAYAISQCVDFFVPVMGRLGNAINPEFIMG---PLGLVIASGFI 601

  Fly   618 IPLVNMF---RRPSLILLTLLAISAVTIYTASSTQIGFPY---RPKTNVQRLPYLHVRRIFYEYD 676
            :.:.|:|   ||.:.|:..|.||.|:.|....:|::|.||   .....::|:..||..|..|:::
Worm   602 LFVNNLFYISRRMNYIIRLLFAIFALFILVLITTKVGNPYEYSHENPRLRRIIALHANRTIYDFE 666

  Fly   677 GTVVKNDSGYLFNFQDRRGPAPLK-------LSKLNTTGLVSIAADCDTVMMCGFPLYD--HRWV 732
            |.:.:.|:....:..|.||.:.|.       .|..|.||:|.        ..|..|.|.  |...
Worm   667 GHLTQKDNALFVHSLDYRGASDLPDHSFLQGSSAPNCTGVVD--------EYCRMPYYTAIHELF 723

  Fly   733 KNRLQIMWLPREEEIITPYEPKLELLSKTELGNNTLRMNFQ-SATTDHASVFIQPLEDVIISNWS 796
            ... |.:|:|....::.||...|:|:|:..:|.| |.:.|: ....|..|:.:.||.|..:.:||
Worm   724 PPE-QSLWVPVPSPVVLPYPIDLKLVSRHAMGEN-LNLTFEIRGGYDKMSLHVTPLNDYDLLSWS 786

  Fly   797 ---LPTSYIGQQDTSHMYFSYG 815
               :.....|::.|..::.:||
Worm   787 FTDIDIKEFGRRQTYFVFMTYG 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	124/319 (39%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	68/263 (26%)
B0495.7	NP_495618.1	M28_Fxna_like	70..382	CDD:193497	126/324 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158700
Domainoid	1	1.000	230	1.000	Domainoid score	I1390
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	359	1.000	Inparanoid score	I1290
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		mtm4849
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810