DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10073 and NAALADL1

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	NP_005459.2	Gene:	NAALADL1 / 10004	HGNCID:	23536	Length:	740	Species:	Homo sapiens

Alignment Length:	213	Identity:	48/213 - (22%)
Similarity:	81/213 - (38%)	Gaps:	64/213 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YLLVNSHFDS---KPTSPSAGDAGQMVVAILEVLRVMCS-TKQAI---RHPVVFLLNGAEENPLQ 231
            |:|..:|.||   ....||:|.|     .:||:.||:.: .|:..   |..:||...||||..|.
Human   362 YVLYGNHRDSWVHGAVDPSSGTA-----VLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLI 421

  Fly   232 ASHGFITQ--HKWAKNCKVVLNLDAAGNGGSDIVFQTGP-------------NSP---------- 271
            .|..|..:  :|..:.....:|:|.:....:.:..|..|             .||
Human   422 GSTEFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDN 486

  Fly   272 WLVEKYKENAPHYLATTMAEEIFQTGILPS------DTDFAIFVKYGNLIGLDMAKFINGF---- 326
            | :..:..::|.|            |::||      .:|:|.||.:..:..:|:|...:..
Human   487 W-IRYFNRSSPVY------------GLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSA 538

  Fly   327 ----AYHTKYDQFSNIPR 340
                .|||.:|.|..:.:
Human   539 RIYPTYHTAFDTFDYVDK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	48/213 (23%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401
NAALADL1	NP_005459.2	Zinc_peptidase_like	46..>121	CDD:387401
		PA_GCPII_like	109..335	CDD:239036
		M28_PSMA_like	<348..587	CDD:349942	48/213 (23%)
		TFR_dimer	616..735	CDD:367885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900