DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10073 and NAALAD2

DIOPT Version :9

Sequence 1:	NP_001261090.1	Gene:	CG10073 / 37225	FlyBaseID:	FBgn0034440	Length:	881	Species:	Drosophila melanogaster
Sequence 2:	XP_016872532.1	Gene:	NAALAD2 / 10003	HGNCID:	14526	Length:	775	Species:	Homo sapiens

Alignment Length:	391	Identity:	78/391 - (19%)
Similarity:	140/391 - (35%)	Gaps:	101/391 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 IHWTMVNMYQGVQNIVIKLSPKNTTSTTYLLVNSHFDS---KPTSPSAGDAGQMVVAIL-EVLR- 205
            :|...:|....:.|:|..:. .:.....|:::..|.||   ....|::|      ||:| |:.|
Human   369 MHVYNINKITRIYNVVGTIR-GSVEPDRYVILGGHRDSWVFGAIDPTSG------VAVLQEIARS 426

  Fly   206 --VMCSTKQAIRHPVVFLLNGAEENPLQASHGFITQHKWA-KNCKVV-------LNLDAAGNGG- 259
              .:.|.....|..::|....|||      .|.:...:|| :|.|::       :|.|::..|.
Human   427 FGKLMSKGWRPRRTIIFASWDAEE------FGLLGSTEWAEENVKILQERSIAYINSDSSIEGNY 485

  Fly   260 ------SDIVFQ-------------TGPNSPWLVEKYKENAPHYLATTMAEEIFQTGILPSDTDF 305
                  :.:::|             .|..|..|.|.:.|..|    :...:.:.:...|.|.:||
Human   486 TLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDP----SPENKNLPRINKLGSGSDF 546

  Fly   306 -AIFVKYGNLIG-------LDMAKFINGFAYHTKYDQFSNIP----------------RG----- 341
             |.|.:.|...|       ....|:.:...|||.|:.|..:.                ||
Human   547 EAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYE 611

  Fly   342 ---------SIQNTGDNLLGLVRSIANSTELDNTEAYATGHAIFFDVLGLYFISYTESNG----- 392
                     :||:..:.|.....||.|.::..:.:  .|.|.:.||.|.....:::|:..
Human   612 LVDSKIIPFNIQDYAEALKNYAASIYNLSKKHDQQ--LTDHGVSFDSLFSAVKNFSEAASDFHKR 674

  Fly   393 ---VILNYSVAGVALVLIFLSIWRTSSISRVSIGHVLCWFILIFVLQIIAFVLGLGLPIVVAYVF 454
               |.||..:| |.::...|.:...:.|..:.:...|.:..:||.........|...|.:...:|
Human   675 LIQVDLNNPIA-VRMMNDQLMLLERAFIDPLGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIF 738

  Fly   455 D 455
            |
Human   739 D 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10073	NP_001261090.1	M28_Fxna_like	80..387	CDD:193497	63/313 (20%)
CG10073	NP_001261090.1	NrfD	398..638	CDD:304401	11/58 (19%)
NAALAD2	XP_016872532.1	Zinc_peptidase_like	93..>139	CDD:301362
		PA_GCPII_like	145..371	CDD:239036	0/1 (0%)
		M28_PSMA_like	373..620	CDD:193568	51/263 (19%)
		TFR_dimer	657..772	CDD:282153	16/84 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900