DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10062 and PFF1

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_009630.3	Gene:	PFF1 / 852366	SGDID:	S000000278	Length:	976	Species:	Saccharomyces cerevisiae

Alignment Length:	843	Identity:	179/843 - (21%)
Similarity:	319/843 - (37%)	Gaps:	265/843 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PLTRSDEASHPNSFIAQRAEDTLIELTRIGPRVVGSMANEESAVEFLRAEVAKVESEMSDLLEIE 113
            |.| |.|....:.::.:|    ::|:|  |.....|:::::             |||.|.|.:.:
Yeast    73 PYT-SKENDKVHDYLLKR----VLEIT--GNSSFASVSDDK-------------ESERSILFQQQ 117

  Fly   114 VDVQQASGAYMHWEMVNMYQGIQNVVVKLSEKNSTNENYLLINSHYDSVPGSPGAGDDGSMVVTM 178
            ....::|    .:..|..::. .|::|||..||...|. ||:::|:||||...||.|||..||::
Yeast   118 DPFNESS----RFSRVTYFES-SNILVKLEGKNPEEEG-LLLSAHFDSVPTGYGATDDGMGVVSL 176

  Fly   179 LEVMRVIAKSGDPLAH----PIVFLFNGAEENPLQASHAFITQHKWAKNCKALINLDSAGSGGRE 239
            |..::...|      |    .::|.||..||..|..:..:. .|.|:...|.:|||:..|:||:.
Yeast   177 LANLKYHIK------HRPNRTLIFNFNNNEEFGLLGASTYF-DHSWSNLTKYVINLEGTGAGGKA 234

  Fly   240 ILFQSGPNHPWLMNYYRNV-PHPFANTLAEELFQAGYIPSDTDFRIFRDYGGVPGLDMAYIFNGY 303
            :||::.......: |.::| .:||.|::.::.|.:.|:.|:||::|:.: .|:.|.|:|:.....
Yeast   235 VLFRTSDTSTARI-YQQSVKENPFGNSIYQQGFYSRYVRSETDYKIYEE-NGMRGWDVAFYKPRN 297

  Fly   304 VYHTKYNRINAFPRASFQHTGDNVLSLARALA--NAPELDDTAAHSEGHNIFYDFLG--WFMI-- 362
            :|||..:.|....:||..|.....|.|:..:|  :....|.|.|      .::||:|  :|:|
Yeast   298 LYHTIKDSIQYTSKASLWHMLHTSLQLSAYVASNSLDTADQTPA------CYFDFIGLKFFVISA 356

  Fly   363 ---FYTETTSIIVNVVVTLLALLGVGISIYFMSLRSGCSWKGVLLRFSISIAIQFVSLILAIGLA 424
               ||.....::|:.|        |.|.:|.:| |...:||
Yeast   357 KTLFYWNCIFLLVSPV--------VAIGLYLIS-RDRMTWK------------------------ 388

  Fly   425 LLVALFMDGVDRSMSWFTSSWTIFGLYLAPIVFGLSILPALYLEKTKRDPLGLGFRIQLFMHSHC 489
                        |.||.  |||.|.|.||.   |:.:......:..:.:|  |.|....|.....
Yeast   389 ------------SYSWL--SWTRFPLSLAA---GIIVQKLFSNDIIRSNP--LTFSRNYFWPISA 434

  Fly   490 ICLIVIMLTLTGLSIRSAYLIMLCILF-----DIVALIVNLVTKWHRKAYLFAIAVTVCQILPLV 549
            ....||.         ::|:::.|..|     |:.:|.:                        :.
Yeast   435 FFTQVIF---------TSYVLINCSNFFFPCADMKSLSI------------------------IE 466

  Fly   550 FFTYLCTVALVTLMPMQGRSGSSTNPDMVIAALVWLFSLMFAGFIAPLIMFFRKTRTIVLCFLGI 614
            .|..|.|:.|.|                  :.|::.....:.|.....|.|...|...:|..|.:
Yeast   467 LFIILWTILLFT------------------SKLLYSSDYRYTGLYPLSIFFLLSTIAAILRLLAL 513

  Fly   615 TILFIIIAVTNAGFPYKEKTSPQ---RYSLIHAHRRLH-NADGSTRIDESGLYIYPQDR------ 669
            .:          |...:::...:   .:|...:|.::. ..||...:::      |||:
Yeast   514 AL----------GMRTRKRLGRECRDHHSNYSSHSQIDMERDGQENLEQ------PQDQLTSSQD 562

  Fly   670 -RFGIAKDNIA--AIGEAHQVSDFCDEEMFCGMPLYNHRWNKARQYSMWIETSESPEIPTEYPML 731
             :..|..||::  :.|.:|.|    ||:         |..:.:.|       .....:|
Yeast   563 DQASIQDDNVSTTSAGPSHNV----DED---------HGMDSSSQ-------QHDERVP------ 601

  Fly   732 VLQDSSELETSAQRRFNFTLAGPSHMGIFINVKNDARILNWSFNDTLIREQAEPPYMVYFSYGLD 796
            :|:.|:.:|.....|.|             ::|.:.....|.....||   ...|..:.|:
Yeast   602 LLKGSNSMEEGLSTREN-------------SLKLEYTDYAWIIQFLLI---VPIPSFILFN---- 646

  Fly   797 DSPLEFTIDV---ELNDYLQK-TTSTFDTPTLEIGIGG---------------HWVTQDITAI 840
                  ::||   .||..:|: :.:|||  .|..|:.|               :::|..:||:
Yeast   647 ------SVDVIMDALNHTVQEGSKATFD--VLRFGMVGSILIALPILPFFYKVNYITISLTAL 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	86/318 (27%)
PFF1	NP_009630.3	M28_Fxna_like	50..354	CDD:349872	89/321 (28%)
PFF1	NP_009630.3	DUF2189	366..>443	CDD:413262	26/137 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343300
Domainoid	1	1.000	99	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm46574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.840