DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10062 and ERMP1

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_079172.2	Gene:	ERMP1 / 79956	HGNCID:	23703	Length:	904	Species:	Homo sapiens

Alignment Length:	862	Identity:	270/862 - (31%)
Similarity:	438/862 - (50%)	Gaps:	59/862 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVLYLSLVNTQMNHMPRPLTRSDEASHPNSFIAQRAEDTLIELTRIGPRVVGSMANEESAVEFLR 96
            |.|||..:.|.:....:.|.....|.|...|.|.:|.|.|..:|.||||..||..||...|.:|.
Human    77 LALYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLL 141

  Fly    97 AEVAKVESEMSDLLEIEVDVQQASGAY---MHWEMVNMYQGIQNVVVKLSEKNSTNENYLLINSH 158
            .::..:|.:.:.|.:|.||||:.:|::   ......:.|..|.||||||..::.. ::.:|.|.|
Human   142 EQIKLIEVQSNSLHKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDGA-QHAVLANCH 205

  Fly   159 YDSVPGSPGAGDDGSMVVTMLEVMRVIAKSGDPLAHPIVFLFNGAEENPLQASHAFITQHKWAKN 223
            :|||..||||.||......||||:||::.|.:.|.|.::|||||||||.|||||.|||||.||..
Human   206 FDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWASL 270

  Fly   224 CKALINLDSAGSGGREILFQSGPNHPWLMN-YYRNVPHPFANTLAEELFQAGYIPSDTDFRIFRD 287
            .:|.|||::||.||:|::||:||.:|||:. |.....||||:.:|:|:||:|.|||||||||:||
Human   271 IRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRD 335

  Fly   288 YGGVPGLDMAYIFNGYVYHTKYNRINAFPRASFQHTGDNVLSLARALANAPELDDTAAHSEGHNI 352
            :|.:||:|:|:|.|||:|||||:..:.....|.|..|||:|::.:.||.:..|...:.:..|:.:
Human   336 FGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNMV 400

  Fly   353 FYDFLGWFMIFYTETTSIIVNVVVTLLALLGVGISIYFMSLRSGCSWKGVLLRFSISIAIQFVSL 417
            |:|.||.|:|.|......|:|.:|.:..:|.:|........::|...|..|....|::...|.||
Human   401 FFDVLGLFVIAYPSRIGSIINYMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGITLISWFTSL 465

  Fly   418 ILAIGLALLVALFMDGVDRSMSWFTSSWTIFGLY----LAPIVFGLSILPALYLEKTKRDPLG-L 477
            :    ..|::|:|:..:.:|:||:...:....||    :|.|:...::....|........|| :
Human   466 V----TVLIIAVFISLIGQSLSWYNHFYVSVCLYGTATVAKIILIHTLAKRFYYMNASAQYLGEV 526

  Fly   478 GFRIQLFMHSHCICLIVIMLTLTGLSIRSAYLIMLCILFDIVA-LIVNLVTKWHRKAYLFAIAVT 541
            .|.|.||:|    |..::.||..||.  ||::..:.:.|.::. |.|:...|.|.....|.....
Human   527 FFDISLFVH----CCFLVTLTYQGLC--SAFISAVWVAFPLLTKLCVHKDFKQHGAQGKFIAFYL 585

  Fly   542 VCQILPLVFFTYLCTVALVTLMPMQGRSGSSTNPDMVIAALVWLFSLMFAGFIAPLIMFFRKTRT 606
            :...:|.::..||.........|:.|||||...||:|:|:::...:::.:.:....|...:.|:.
Human   586 LGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYFINFIYLAKSTKK 650

  Fly   607 IVLCFLGITILFIIIAVTNAGFPYKEKTS---PQRYSLIHAHRRLHNADGSTRIDESGLYIYPQD 668
            .:|....:..:..::..:...|||....:   |:|..|.|..|..|:.:|:....:||::|...|
Human   651 TMLTLTLVCAITFLLVCSGTFFPYSSNPANPKPKRVFLQHMTRTFHDLEGNAVKRDSGIWINGFD 715

  Fly   669 RRFGIA--KDNIAAIGEAHQVSDFCDEEM-FCGMPLY-------NHRWNKARQYSMWIETSE-SP 722
            .. ||:  ..:|..|.::  :...|:|.. .||.|.|       ...|        ::...| ||
Human   716 YT-GISHITPHIPEINDS--IRAHCEENAPLCGFPWYLPVHFLIRKNW--------YLPAPEVSP 769

  Fly   723 EIPTEYPMLVLQDSSELETSAQRRFNFTLAGPSHMGIFINVKNDARILNWSF-NDTLIREQAEPP 786
            ..|..:.::    |.|.......:..|...|||||..::.....:.:..||. |.|.:..:. ..
Human   770 RNPPHFRLI----SKEQTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSLGNGTPVTSKG-GD 829

  Fly   787 YMVYFSYGLDDSPLEFTIDVELNDYLQKTTSTFDTPTLEIGIGGHWVTQDITAIEKLSSYINRFP 851
            |.|::|:||..|..:|.|:|::::...:...|       :.|..|:::.:.....:|.:...:||
Human   830 YFVFYSHGLQASAWQFWIEVQVSEEHPEGMVT-------VAIAAHYLSGEDKRSPQLDALKEKFP 887

  Fly   852 SYAYIQGWVGTYETWYF 868
            .:.:...||.||:.:.|
Human   888 DWTFPSAWVCTYDLFVF 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	141/308 (46%)
ERMP1	NP_079172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
ERMP1	NP_079172.2	M28_Fxna_like	104..412	CDD:193497	141/308 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145819
Domainoid	1	1.000	238	1.000	Domainoid score	I2299
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1816
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm40549
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770