DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10062 and Ermp1

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_006231303.1	Gene:	Ermp1 / 373544	RGDID:	727831	Length:	899	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	268/875 - (30%)
Similarity:	431/875 - (49%)	Gaps:	84/875 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVLYLSLVNTQMNHMPRPLTRSDEASHPNSFIAQRAEDTLIELTRIGPRVVGSMANEESAVEFLR 96
            |.|||..:...:....:.|..|..:.....|.|::|...|..:|.||||..||..||...|::|.
  Rat    71 LALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARVYLEHITAIGPRTTGSAENEILTVQYLL 135

  Fly    97 AEVAKVESEMSDLLEIEVDVQQASGAY---MHWEMVNMYQGIQNVVVKLSEKNSTNENYLLINSH 158
            .::..:|.:.:.|..|.||||:.:|::   ......:.|..|.||||||..::.. :..:|.|.|
  Rat   136 EQITLIEEQSNSLHRISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPQDGA-KYAVLANCH 199

  Fly   159 YDSVPGSPGAGDDGSMVVTMLEVMRVIAKSGDPLAHPIVFLFNGAEENPLQASHAFITQHKWAKN 223
            :|||..||||.||......||||:||:|.|.:||.|.:||||||||||.|||||.|||||.||..
  Rat   200 FDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVFLFNGAEENVLQASHGFITQHPWASL 264

  Fly   224 CKALINLDSAGSGGREILFQSGPNHPWLMN-YYRNVPHPFANTLAEELFQAGYIPSDTDFRIFRD 287
            .:|.|||::||.||:|::||:||.:|||:. |.....||||:.:|:|:||:|.|||||||||:||
  Rat   265 IRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRD 329

  Fly   288 YGGVPGLDMAYIFNGYVYHTKYNRINAFPRASFQHTGDNVLSLARALANAPELDDTAAHSEGHNI 352
            :|.:||:|:|:|.|||:|||||:..:.....|.|..|||:|::.:.||.:..|..::.:..|..:
  Rat   330 FGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNILAVLKYLATSDMLASSSEYRHGSMV 394

  Fly   353 FYDFLGWFMIFYTETTSIIVNVVVTLLALLGVGISIYFMSLRSGCSWKGVLLRFSISIAIQFVSL 417
            |:|.||..:|.|......|:|.:|.:..:|.:|..:    ||........:..|...:.|.|:|.
  Rat   395 FFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKL----LRPKHRNSNYVRDFLCGLGITFISW 455

  Fly   418 ILAIGLALLVALFMDGVDRSMSWFTSSWTIFGLYLAPIVFGLSILPALYLEKT--KR------DP 474
            ..::...|::|:|:..:.:|:||:..      .|:|..::|.:.:..:.|..|  ||      ..
  Rat   456 FTSLVTVLIIAVFVSLIGQSLSWYNY------FYIAVCLYGTATVAKIILIHTLAKRFYYVNASD 514

  Fly   475 LGLG---FRIQLFMHSHCICLIVIMLTLTGLSIRSAYLIMLCILFDIVA-LIVNLVTKWHRKAYL 535
            |.||   |...||:|    |..::.||..|..  ||::..:.:.|.::. |.|....|.|.....
  Rat   515 LYLGELFFDTSLFVH----CGFLVALTAQGFC--SAFMSAVWVAFPLLTKLCVYKDFKKHGAKGR 573

  Fly   536 FAIAVTVCQILPLVFFTYLCTVALVTLMPMQGRSGSSTNPDMVIAALVWLFSLMFAGFIAPLIMF 600
            |.....:...:|.::..||.........|:.|||||...||:|:|:::.:..::.:.:....|..
  Rat   574 FIALYLLGMFIPYLYGLYLIWAVFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYL 638

  Fly   601 FRKTRTIVLCFLGITILFIIIAVTNAGFPYK---EKTSPQRYSLIHAHRRLHNADGSTRIDESGL 662
            ...|:..:|..:.:..:..::..:.|.|||.   :...|:|..|.|..|..||.:||....:||:
  Rat   639 VNSTKKTILTLILVCAVTFLLVCSGAFFPYSSNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSGI 703

  Fly   663 YIYPQDRRFGIAKDNIAAIGEAH------QVSD----FCDEEM-FCGMPLY-------NHRWNKA 709
            :|           :.....|.:|      :::|    .|:|.. .||.|.|       ...|
  Rat   704 WI-----------NGFDYTGMSHVTPHIPEINDTIRAHCEENAPLCGFPWYLPVHFLIRKNW--- 754

  Fly   710 RQYSMWIETSE-SPEIPTEYPMLVLQDSSELETSAQRRFNFTLAGPSHMGIFINVKNDARILNWS 773
                 ::...| ||..|..:.::    |.|.......:..|...|||||..::.....:.:..||
  Rat   755 -----YLPAPEISPRNPAHFRLV----SKEKMPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWS 810

  Fly   774 FNDTLIREQAEPPYMVYFSYGLDDSPLEFTIDVELNDYLQKTTSTFDTPTLEIGIGGHWVTQDIT 838
            ..:.:........|.|::|:||..|..:|.|:|      |:.:.......:.:.|..|:::.:..
  Rat   811 LGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEV------QQVSEEQPEGMVTVAIAAHYLSGENK 869

  Fly   839 AIEKLSSYINRFPSYAYIQGWVGTYETWYF 868
            ...:|.:...:||.:::...||.||..:.|
  Rat   870 RSSQLDALKEKFPDWSFPSAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	142/308 (46%)
Ermp1	XP_006231303.1	M28_Fxna_like	99..406	CDD:193497	142/307 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339528
Domainoid	1	1.000	242	1.000	Domainoid score	I2158
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1759
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm44686
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770