DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10062 and CG10051

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	877	Identity:	379/877 - (43%)
Similarity:	544/877 - (62%)	Gaps:	24/877 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFNSKYHIDVDFEV------PKKLQWYYAPAFFGFWLVLYLSLVNTQMNHMPRPLTRSDEASHP 59
            |||::   :|:..|.      .||..|:.||.:......|:.:.|.......|:.|.:|:||.||
  Fly     1 MSFST---VDITEEKDGGKSRDKKWPWFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSEEALHP 62

  Fly    60 NSFIAQRAEDTLIELTRIGPRVVGSMANEESAVEFLRAEVAKVESEMS-DLLEIEVDVQQASGAY 123
            :.||.:||...|.|.:.||.::.||:.||...:.||..|:.|::.|.. ||.:||||.|.:|||:
  Fly    63 DKFIGERAMRQLAEYSAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAF 127

  Fly   124 MHWEMVNMYQGIQNVVVKLSEKNSTNENYLLINSHYDSVPGSPGAGDDGSMVVTMLEVMRVIAKS 188
            ..|.|...|..:.|||||:|:|:|.||||||:||||||...:|.|||||.|||.|||.:|||::|
  Fly   128 HLWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRS 192

  Fly   189 GDPLAHPIVFLFNGAEENPLQASHAFITQHKWAKNCKALINLDSAGSGGREILFQSGPNHPWLMN 253
            ...|.||:|||||||||..:..||.|||||||:||||||:||||.|:||||:|||:|||||||..
  Fly   193 ERTLTHPVVFLFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAK 257

  Fly   254 YYR-NVPHPFANTLAEELFQAGYIPSDTDFRIFRDYGGVPGLDMAYIFNGYVYHTKYNRINAFPR 317
            ||: :||||:|.||||||||..:||||||||||||||||||||||.:.|||||||:::.......
  Fly   258 YYQASVPHPYAQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEY 322

  Fly   318 ASFQHTGDNVLSLARALANAPELDDTAAHSEGHNIFYDFLGWFMIFYTETTSIIVNVVVTLLALL 382
            .::|.||:|||.|..|||||||||:|.|:.:||.::||||||||:.|||:.||.:||||::.|.:
  Fly   323 GTYQSTGENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFI 387

  Fly   383 GVGISIYFMSLRSGC-SWKGVLLRFSISIAIQFVSLILAIGLALLVALFMDGVDRSMSWFTSSWT 446
            .:|.|:|.|:|.:|. :.|.|:|||:|...:|..:|.:|.||.||||:||.||..:.||:...|.
  Fly   388 CIGTSVYIMTLDNGADAPKAVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYYGKWM 452

  Fly   447 IFGLYLAPIVFGLSILPALYLEKTKRDP-LGLGFRIQLFMHSHCICLIVIMLTLTGLSIRSAYLI 510
            .||||...:.|...||||.|:..|||.. :.|...|..|||:.||.|.::.:.:|.:.|||:|..
  Fly   453 AFGLYFCTLFFAFGILPATYIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMGIRSSYFP 517

  Fly   511 MLCILFDIVALIVNLVTKWHRKAYLFAIAVTVCQILPLVFFTYLCTVALVTLMPMQGRSGSSTNP 575
            |:.|.|..::::|.:|.|...|...|.....:.|:||..|:||:|...|||.:||:||.|..::|
  Fly   518 MVGIFFYAISVLVQIVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDGPESSP 582

  Fly   576 DMVIAALVWLFSLMFAGFIAPLIMFFRKTRTIVLCFLGITILFIIIAVTNAGFPYKEKTSPQRYS 640
            |::|:..:...::.:|||:.|::..|||.:.|...|..|||:|||:|.|:||||:.::.:||||.
  Fly   583 DIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTSAGFPFVKQLAPQRYY 647

  Fly   641 LIHAHRRLHNADGSTRIDESGLYIYPQDRRFGIAKDNIAAIGEAHQ-VSDFCDEEMFCGMPLYNH 704
            ::|..|..||.||:::.| ||.||.|.|.|.....|......|... .:..|..|.:||:|||:.
  Fly   648 VLHTQRTFHNLDGTSKQD-SGYYIQPVDTRLHELDDTTFKNAEPESWTAATCAAEPYCGLPLYSG 711

  Fly   705 RWNKARQYSMWIETSESPEIPTEYPMLVLQDSSELETSAQRRFNFTLAGPSHMGIFINVKNDARI 769
            ||.:.:..:.||.:| .|.||....:..|...| |:.: :.|:.:.|.....:.::|:..::.::
  Fly   712 RWIEWKDSARWIYSS-PPVIPMNINLTQLSKQS-LDGN-KVRYEYNLRASDRVMMYIDPLDNVKV 773

  Fly   770 LNWSFNDTLIREQAEPPYMVYFSYGLDDSPLEFTIDVELNDYLQKTTSTFDTPTLEIGIGGHWVT 834
            .:|||:.|.:.|:..|||::|..|...:.||.|.:::|..:      ...|.|.:::.:..|:..
  Fly   774 TDWSFDHTPLVEKHTPPYLIYAIYSQTEEPLNFWVELEHEE------GNTDGPYMKLVVSEHFQY 832

  Fly   835 QDITAIEKLSSYINRFPSYAYIQGWVGTYETW 866
            ......|:...::..||.:.|...|....|:|
  Fly   833 HPEYYTEEYKEFLATFPDWTYTTDWFSALESW 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	185/306 (60%)
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	185/306 (60%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	99/242 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446922
Domainoid	1	1.000	62	1.000	Domainoid score	I3747
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800