DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10062 and CG13160

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001260918.1	Gene:	CG13160 / 36343	FlyBaseID:	FBgn0033720	Length:	875	Species:	Drosophila melanogaster

Alignment Length:	889	Identity:	372/889 - (41%)
Similarity:	563/889 - (63%)	Gaps:	49/889 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SFNSKYHIDVDFEVPKKLQWYYAPAFFGFWLVLYLSLVNTQMNHMPRPLTRSDEASHPNSFIAQR 66
            |.|....:|.|....|:..||:||.:..||:.|:.:::......:|..:..|:||..|..|:|:|
  Fly    14 SENLIIEVDEDKIRCKQYSWYFAPIYLLFWVGLFFAVIYPLFQALPTGIKISEEADKPGQFVAER 78

  Fly    67 AEDTLIELTRIGPRVVGSMANEESAVEFLRAEVAKVESEM-SDLLEIEVDVQQASGAYMHWEMVN 130
            |::.|::::|:||||||.:.||.:.|..|.||:.||...: .|:.|:||:||:|||:|:...:.|
  Fly    79 AQEILLQISRLGPRVVGDVDNEVTVVNLLLAEIEKVRQVLRDDVYEMEVEVQRASGSYLIKGLTN 143

  Fly   131 MYQGIQNVVVKLSEKNSTNENYLLINSHYDSVPGSPGAGDDGSMVVTMLEVMRVIAKSGDPLAHP 195
            .|||:|||:|:||.|:|.:.:|||:|||||:.|||||||||.:|||.||||:|::|.||||..||
  Fly   144 HYQGVQNVIVRLSTKSSNSTSYLLVNSHYDTKPGSPGAGDDAAMVVVMLEVLRLVAVSGDPFLHP 208

  Fly   196 IVFLFNGAEENPLQASHAFITQHKWAKNCKALINLDSAGSGGREILFQSGPNHPWLMNYYRN-VP 259
            |:||||||||.|:|.||.|||||:||.|||||:||||||:|||::|||.||||||||.:||| .|
  Fly   209 IIFLFNGAEEQPMQGSHGFITQHRWAANCKALLNLDSAGAGGRDLLFQGGPNHPWLMEHYRNSAP 273

  Fly   260 HPFANTLAEELFQAGYIPSDTDFRIFRDYGGVPGLDMAYIFNGYVYHTKYNRINAFPRASFQHTG 324
            ||||.|.|||:|:||.||||||||||||:|.|||||||.::||:|||||::|.......|.|::|
  Fly   274 HPFATTTAEEMFEAGIIPSDTDFRIFRDFGVVPGLDMAGVYNGFVYHTKFDRYAVISLDSLQNSG 338

  Fly   325 DNVLSLARALANAPELDDTAAHSEGHNIFYDFLGWFMIFYTETTSIIVNVVVTLLALLGVGISIY 389
            ||:|:|..:::||.|:.||.||:.||.:|:||:|.|.:.|.|:||:.:|:..:..|:|.|.||::
  Fly   339 DNLLALVWSISNAEEMYDTEAHAAGHAVFFDFIGLFFVHYQESTSLALNLFFSFGAILLVCISLW 403

  Fly   390 FMSLRSG---CSWKGVLLRFSISIAIQFVSLILAIGLALLVALFMDGVDRSMSWFTSSWTIFGLY 451
            .||..:|   .::.||   |.:...:.....:||:...||:|.|.|..:|::::|::||.:.|||
  Fly   404 RMSRVTGQTMGTYAGV---FGLLFLLALAGALLAVAFPLLMATFYDWGNRTLTYFSNSWLVIGLY 465

  Fly   452 LAPIVFGLSILPALYLEKTKRDPLGLGFRIQLFMHSHCICLIVIMLTLTGLSIRSAYLIMLCILF 516
            :.|.|.||.:...|||..||.:.:...:.:.:..|::|:.|.::.|..|.|..|||||.::.::|
  Fly   466 ICPSVIGLVLPMTLYLTHTKCNKIPHTYYLHIVGHANCVLLAILCLGATALKYRSAYLFLISLIF 530

  Fly   517 DIVALIVNLVTKWHRKAYLFAIAVTVCQILPLVFFTYLCTVALVTLMPMQGRSGSSTNPDMVIAA 581
            .:.|||:||:|:.|.:.||:::.:.|.||:|.::..||..:.::.|:||.||.|.|||||::|.|
  Fly   531 YVAALIINLLTRLHCRGYLWSLVLIVFQIIPFIYHAYLFHMFILILIPMTGRFGVSTNPDILIGA 595

  Fly   582 LVWLFSLMFAGFIAPLIMFFRKTRTIVLCFLG----ITILFIIIAVTNAGFPYKEKTSPQRYSLI 642
            |....:::...|.||||..||:..    |.||    :..:|.:|||::.||||:.||:..|...:
  Fly   596 LCGFGTILALSFAAPLINVFRRPN----CMLGGLALVMFIFCMIAVSDVGFPYRPKTNVMRADFM 656

  Fly   643 HAHRRLHNADGSTRIDESGLYIYPQDR------RFGIAKDNIAAIGEAHQVSDFCDEEMFCGMPL 701
            ..||:....:||...::||.|.:..||      |..:...|:..:||.      ||.|:.||:|.
  Fly   657 QVHRKFFEYNGSISHEDSGYYFHLGDRNKEAPLRDHMNLTNLVRLGED------CDSELMCGIPC 715

  Fly   702 YNHRWNKARQYSMWIETSESPEIPTEYP-MLVLQDSSELETSAQRRFNFTLAGPSHMGIFINVKN 765
            |  |:..||::::|:...|..|:|  || :|.....:.|....|.|:.|.|.||.:||:|....:
  Fly   716 Y--RYCSAREHALWLAREEPVELP--YPTVLEFLSKTVLSGGYQVRYEFRLTGPPNMGLFFKPLD 776

  Fly   766 DARILNWSFNDTLIREQA--EPPYMVYFSYGLDDSPLEFTIDVELNDYLQKTTSTFDTPTLEIGI 828
            ..::|.|:|...::...|  .||..|..:||:|::|:||.::      |.|....|:.|..|:|:
  Fly   777 GVKLLRWTFAPAMLDNPATYRPPLEVMLTYGIDNTPIEFFVE------LSKDDGNFNEPVFEMGV 835

  Fly   829 GGHWVT----QDITAIEKLSSYINRFPSYAYIQGWVGTYETWYF 868
            .||:|:    :|..::|.|::    .|.:|:...|..:||...|
  Fly   836 SGHYVSPHDKRDALSLEFLAT----LPDFAFSMEWPSSYERHIF 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	184/306 (60%)
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:193497	184/306 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446909
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800