DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10062 and Tfrc

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	NP_001344227.1	Gene:	Tfrc / 22042	MGIID:	98822	Length:	763	Species:	Mus musculus

Alignment Length:	273	Identity:	59/273 - (21%)
Similarity:	99/273 - (36%)	Gaps:	60/273 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 VTNAGFPYKEKTSPQRYSL-----------IHAHRRLHNADGSTRIDESGLYIYPQDRRFGIAKD 676
            :.:|.|..|:......||:           |....::.||.....|   |:.||....:|.:.:.
Mouse   234 LVHANFGTKKDFEELSYSVNGSLVIVRAGEITFAEKVANAQSFNAI---GVLIYMDKNKFPVVEA 295

  Fly   677 NIAAIGEAHQVSDFCDEEMFCGMPLYNHRWNKARQYSMWIETSESPEIPTEYPMLVLQDSSE--- 738
            ::|..|.||..:   .:....|.|.:||......|      :|..|.||.:   .:.:.::|
Mouse   296 DLALFGHAHLGT---GDPYTPGFPSFNHTQFPPSQ------SSGLPNIPVQ---TISRAAAEKLF 348

  Fly   739 --LETSAQRRFN------FTLAGPSHMGIFI-NVKNDARILNWSFNDTLIREQAEPPYMVYFSYG 794
              :|.|...|:|      ..|:...::.:.: ||..:.|||| .|.  :|:...||..  |...|
Mouse   349 GKMEGSCPARWNIDSSCKLELSQNQNVKLIVKNVLKERRILN-IFG--VIKGYEEPDR--YVVVG 408

  Fly   795 LDDSPLEFTIDVELN---DYLQKTTSTFD--------TPTLEIGIGGHWVTQDITAI---EKLSS 845
            .....|...:..:.:   ..|.|....|.        .|:..| |...|...|..|:   |.|..
Mouse   409 AQRDALGAGVAAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSI-IFASWTAGDFGAVGATEWLEG 472

  Fly   846 YIN--RFPSYAYI 856
            |::  ...::.||
Mouse   473 YLSSLHLKAFTYI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497
Tfrc	NP_001344227.1	Mediates interaction with SH3BP4. /evidence=ECO:0000250	1..67
		Endocytosis signal	20..23
		Stop-transfer sequence	58..61
		PA_TfR	203..379	CDD:239043	32/159 (20%)
		Zinc_peptidase_like	387..613	CDD:326366	25/105 (24%)
		Ligand-binding. /evidence=ECO:0000250	572..763
		TFR_dimer	645..749	CDD:309400
		Cell attachment site. /evidence=ECO:0000255	649..651
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900