DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10062 and ermp1

DIOPT Version :9

Sequence 1:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster
Sequence 2:	XP_004910853.1	Gene:	ermp1 / 100145630	XenbaseID:	XB-GENE-984733	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	874	Identity:	266/874 - (30%)
Similarity:	437/874 - (50%)	Gaps:	86/874 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LVLYL----SLVNTQMNHMPRPLTRSDEASHPNSFIAQRAEDTLIELTRIGPRVVGSMANEESAV 92
            |:||:    .||:..:..:..|      ..|...|.|..|.:.|.::|.|..|:|||..||..||
Frog    52 LLLYVLGVRGLVHISLRQLVTP------GGHSTGFNASTAREYLQQITSIDSRIVGSPENEIIAV 110

  Fly    93 EFLRAEVAKVESEMSDLLEIEVDVQQASGAY---MHWEMVNMYQGIQNVVVKLSEKNSTNENYLL 154
            ::|..::..:|.:::.:.:|.||||:.:|.:   ......:.|..|.|:.||| |.....|:.:|
Frog   111 DYLLGKIKDIEEKVNSVHKITVDVQRPTGTFSIDFLGGFTSYYDNITNIAVKL-EPEFGAEHAVL 174

  Fly   155 INSHYDSVPGSPGAGDDGSMVVTMLEVMRVIAKSGDPLAHPIVFLFNGAEENPLQASHAFITQHK 219
            .|.|:|||..:|||.||......|||::..::.|..||.|.|:|||||||||.||.||.|||||.
Frog   175 ANCHFDSVANTPGASDDAVSCAVMLEILGSLSVSSKPLRHAIIFLFNGAEENILQGSHGFITQHP 239

  Fly   220 WAKNCKALINLDSAGSGGREILFQSGPNHPWLMNYYR-NVPHPFANTLAEELFQAGYIPSDTDFR 283
            |||..:|.|||::||.||:|::||:||.:|||:..|. ...||||:.:|:|:||:|.||||||||
Frog   240 WAKMVRAFINLEAAGVGGKELVFQTGPENPWLVQAYALAAVHPFASVVAQEVFQSGIIPSDTDFR 304

  Fly   284 IFRDYGGVPGLDMAYIFNGYVYHTKYNRINAFPRASFQHTGDNVLSLARALANAPELDDTAAHSE 348
            |:||:|.:||:|:|:|.|||:|||||:..|.....|.|..|||:|.:...||.:.:|.:::....
Frog   305 IYRDFGNIPGIDLAFIENGYIYHTKYDTWNRILTESIQRAGDNILGVLHYLATSSQLAESSKFRH 369

  Fly   349 GHNIFYDFLGWFMIFYTETTSIIVNVVVTLLALLGVGISIYFMSLRSGCSW-KGVLLRFSISIAI 412
            |:.:|:|..|.|::.|......|:|.:...:.|..:|..| ....:.|.:: :.::..|.|::
Frog   370 GNMVFFDVCGLFVLSYPARLGTIINYITAAVTLFYIGKKI-IKYKQGGTNYARDLVYGFLITL-- 431

  Fly   413 QFVSLILAIGLALLVALFMDGVDRSMSWFTSSWTIFGLY----LAPIVFGLSILPALYLEKTKRD 473
              ||.:.|:...|::|:.:....:::.|:|..:....||    :|.::...|:....:.......
Frog   432 --VSWVSALVTVLIIAVLVSLAGKALFWYTHFYVSVFLYGSAAVAKLILVHSLAKTFFFAGASSQ 494

  Fly   474 PLG-LGFRIQLFMHSHCICLIVIMLTLTGLSIRSAYLIMLCILFDIVALIVNLVTKWHR-KAYLF 536
            .|| :.|.|.|.:.    |:.:::||.:||.  |||.....|:|.::..::......|: ..|.|
Frog   495 YLGDVFFDISLIIW----CIPLVLLTQSGLC--SAYFFAAWIIFPLLTKLLLQPDIIHQGSPYKF 553

  Fly   537 AIAVTVCQILPLVFFTYLCTVALV-----TLMPMQGRSGSSTNPDMVIAALVWLFSLMFAGFIAP 596
                ||..:|.| |..||.|:..|     ...|:.||||:...||:|:..|:...::|...:...
Frog   554 ----TVIYLLGL-FPPYLHTMYHVWAVFEMFTPILGRSGTEIPPDVVLGFLIIACTIMLISYFIS 613

  Fly   597 LIMFFRKTRTIVLCFLGITILFIIIAVTNAGFPYKEKT---SPQRYSLIHAHRRLHNADGSTRID 658
            .|...:.|:.|::....:::|..::..:...|||...|   .|:|..|.|..|..|:..|.....
Frog   614 FIYLVKNTKNIIVPLAVLSVLTFLLVCSGMFFPYSSSTDSPKPKRIFLQHTTRTFHSLTGEVVKK 678

  Fly   659 ESGLYIYPQDRRFGIAKDNIAAIGEAHQVSDF----------CDEEMFCGMPLYNHRWNKARQYS 713
            :||::|           :.....|.:|....|          ||:...||.|.|....|..|:
Frog   679 DSGIWI-----------NGFDYTGISHVTPHFPELNDTVRAPCDDAPLCGFPWYFPVHNLIRK-- 730

  Fly   714 MWIETSESPEIP----TEYPMLVLQDSSELETSAQRRFNFTLAGPSHMGIFINVKNDARILNWSF 774
            .|.  ..:|..|    ||:.::..::.|...|    |.:|...|||||.:::....|:.:.:||.
Frog   731 NWY--LPAPPAPIYEHTEFKLVSREEMSWGTT----RLHFEAKGPSHMTVYVRPHADSVLSSWSL 789

  Fly   775 NDTLIREQAEPPYMVYFSYGLDDSPLEFTIDVELNDYLQKTTSTFDTPTLEIGIGGHWVTQDITA 839
            .|.:.....|..|.:::|:||.....:|.|:|       |.::......:.:.:|.|:...|...
Frog   790 GDGIPIASGEKDYFIFYSHGLYAPAWKFWIEV-------KNSADESKGIVTVAVGSHYFFGDSRN 847

  Fly   840 IEKLSSYINRFPSYAYIQGWVGTYETWYF 868
            ...|.:...:||.:::...||.||:.:.:
Frog   848 SPHLKTVELKFPDWSFPSSWVCTYDLYVY 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	136/308 (44%)
ermp1	XP_004910853.1	M28_Fxna_like	78..385	CDD:349872	136/307 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2323
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1875
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm47728
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060