DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9416 and PFF1

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_009630.3	Gene:	PFF1 / 852366	SGDID:	S000000278	Length:	976	Species:	Saccharomyces cerevisiae

Alignment Length:	532	Identity:	131/532 - (24%)
Similarity:	217/532 - (40%)	Gaps:	130/532 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEIGDI 100
            ::..|||  |......|           :..:.||:      :|:....|...|      .:.|.
Yeast    66 IITASFH--PYTSKEND-----------KVHDYLLK------RVLEITGNSSFA------SVSDD 105

  Fly   101 IDDARTDLYDIEKDVQVASGNYLLWSMVNVYQSIQNVVVKLSPKNATSEAALLINSHFDSVPGSS 165
            .:..|:.|:..:.....:|    .:|.|..::| .|::|||..|| ..|..||:::||||||...
Yeast   106 KESERSILFQQQDPFNESS----RFSRVTYFES-SNILVKLEGKN-PEEEGLLLSAHFDSVPTGY 164

  Fly   166 GAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHPWAQNIRAVINLD 230
            ||.|.||..|.:|..|:...|:....|  ::|.||..||..|.|:..:. .|.|:...:.||||:
Yeast   165 GATDDGMGVVSLLANLKYHIKHRPNRT--LIFNFNNNEEFGLLGASTYF-DHSWSNLTKYVINLE 226

  Fly   231 SAGSGGREILFQSGPDHPWLMKYYGKNI-VHPFASTIGEELFQNGFVPSETDYRVFRDYGHIPGL 294
            ..|:||:.:||::....  ..:.|.::: .:||.::|.::.|.:.:|.|||||:::.:.| :.|.
Yeast   227 GTGAGGKAVLFRTSDTS--TARIYQQSVKENPFGNSIYQQGFYSRYVRSETDYKIYEENG-MRGW 288

  Fly   295 DMAQTLNGYVYHTKYDRFNLIPRRT--YQL-TGENILALV--KALANAEELENPSKYAEGHMIFF 354
            |:|......:|||..|......:.:  :.| |...:.|.|  .:|..|:  :.|:.|       |
Yeast   289 DVAFYKPRNLYHTIKDSIQYTSKASLWHMLHTSLQLSAYVASNSLDTAD--QTPACY-------F 344

  Fly   355 DMMGW-FFVYYPETTGIIINITVCVLVCVTIVLYIWMMSSSTGMFRRRIWAKFGILAALQLAGVA 418
            |.:|. |||...:|                  |:.|..                         :.
Yeast   345 DFIGLKFFVISAKT------------------LFYWNC-------------------------IF 366

  Fly   419 LGIGLVISIALFLDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIVPAIYFSRTKEHGLPLGYG--- 480
            |.:..|::|.|:|.:.: .|:|.|.:|:.:..:  |:....||:....||.......||.:.
Yeast   367 LLVSPVVAIGLYLISRD-RMTWKSYSWLSWTRF--PLSLAAGIIVQKLFSNDIIRSNPLTFSRNY 428

  Fly   481 --------IQLLMHSHCLI----LTIITAIMVSYSIRSAFVIMLCI----------------GFY 517
                    .|::..|:.||    .....|.|.|.||...|:|:..|                |.|
Yeast   429 FWPISAFFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWTILLFTSKLLYSSDYRYTGLY 493

  Fly   518 TLSVLINLVTKA 529
            .||:...|.|.|
Yeast   494 PLSIFFLLSTIA 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	88/313 (28%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	34/138 (25%)
PFF1	NP_009630.3	M28_Fxna_like	50..354	CDD:349872	92/333 (28%)
PFF1	NP_009630.3	DUF2189	366..>443	CDD:413262	17/79 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343303
Domainoid	1	1.000	99	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm46574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870