DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9416 and ERMP1

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_079172.2	Gene:	ERMP1 / 79956	HGNCID:	23703	Length:	904	Species:	Homo sapiens

Alignment Length:	869	Identity:	270/869 - (31%)
Similarity:	443/869 - (50%)	Gaps:	87/869 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LLFYLVVIPSFHRMP-QLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLL 94
            |..||:.:.:..::. |...|.......|:|...:|.:.|..::.|||:..||..||.:.|.:||
Human    77 LALYLIALRTLVQLSLQQLVLRGAAGHRGEFDALQARDYLEHITSIGPRTTGSPENEILTVHYLL 141

  Fly    95 SEIGDIIDDARTDLYDIEKDVQVASGNY---LLWSMVNVYQSIQNVVVKLSPKNATSEAALLINS 156
            .:| .:|:.....|:.|..|||..:|::   .|....:.|.:|.||||||.|::. ::.|:|.|.
Human   142 EQI-KLIEVQSNSLHKISVDVQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPRDG-AQHAVLANC 204

  Fly   157 HFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHPWAQ 221
            |||||..|.||.|..:.|.:|||||||::.....|.::|:|||||||||.||.||.||||||||.
Human   205 HFDSVANSPGASDDAVSCSVMLEVLRVLSTSSEALHHAVIFLFNGAEENVLQASHGFITQHPWAS 269

  Fly   222 NIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETDYRVFR 286
            .|||.|||::||.||:|::||:||::|||::.|.....|||||.:.:|:||:|.:||:||:|::|
Human   270 LIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYR 334

  Fly   287 DYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANAEELENPSKYAEGHM 351
            |:|:|||:|:|...|||:||||||..:.|...:.|..|:||||::|.||.::.|...|||..|:|
Human   335 DFGNIPGIDLAFIENGYIYHTKYDTADRILTDSIQRAGDNILAVLKHLATSDMLAAASKYRHGNM 399

  Fly   352 IFFDMMGWFFVYYPETTGIIINITVCVLVCVTIVLYI----WMMSSSTGMFRRRIWAKFGILAAL 412
            :|||::|.|.:.||...|.|||    .:|.:.:|||:    ......||.:::......||
Human   400 VFFDVLGLFVIAYPSRIGSIIN----YMVVMGVVLYLGKKFLQPKHKTGNYKKDFLCGLGI---- 456

  Fly   413 QLAGVALGIGLVISIALFLDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIVPAI-----------Y 466
            .|......:..|:.||:|:..:...:||::.      .|....::|...|..|           |
Human   457 TLISWFTSLVTVLIIAVFISLIGQSLSWYNH------FYVSVCLYGTATVAKIILIHTLAKRFYY 515

  Fly   467 FSRTKEHGLPLGYGIQLLMHSHCLILTIITAIMVSY-SIRSAFVIMLCIGFYTLSVL-INLVTKA 529
            .:.:.::...:.:.|.|.:|. |.::|:      :| .:.|||:..:.:.|..|:.| ::...|.
Human   516 MNASAQYLGEVFFDISLFVHC-CFLVTL------TYQGLCSAFISAVWVAFPLLTKLCVHKDFKQ 573

  Fly   530 HKTNFLWLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGRE-CNTNPEILMGFFTALMVLLFAPFL 593
            |.....::..:.:...:|:::..|..:|.:.:|.|:.||. ....|::::....|...::.:.:.
Human   574 HGAQGKFIAFYLLGMFIPYLYALYLIWAVFEMFTPILGRSGSEIPPDVVLASILAGCTMILSSYF 638

  Fly   594 VPLFCLFRKS-KTIISMFGICTIVFIIFAATPIAFPYAEKTA---PQRFFAVHTARTFHNGDPAS 654
            :....|.:.: ||::::..:|.|.|::..:... |||:...|   |:|.|..|..||||  |...
Human   639 INFIYLAKSTKKTMLTLTLVCAITFLLVCSGTF-FPYSSNPANPKPKRVFLQHMTRTFH--DLEG 700

  Fly   655 TVSHKDSGYFVLPVDR------RPHTVDDILFENTNFTKSERIDCDSEL-MCGFPIY-SSRWLNA 711
            ....:|||.::...|.      .||..:        ...|.|..|:... :||||.| ...:|
Human   701 NAVKRDSGIWINGFDYTGISHITPHIPE--------INDSIRAHCEENAPLCGFPWYLPVHFL-- 755

  Fly   712 VDNSYFVPGPEPNREYIPTLTILEKSSNSDTNIRFDLEISGPDHTSIFILPLNDSKLVDWSFIRD 776
            :..::::|.||.:....|...::.|......:|:...|.:||.|.|.::.....|.|..||.
Human   756 IRKNWYLPAPEVSPRNPPHFRLISKEQTPWDSIKLTFEATGPSHMSFYVRAHKGSTLSQWSL--- 817

  Fly   777 PLDGNVKP------PYYVYWSYALDPKPLQFSLEFE--HEDPNWSGGTFKIALMGHRIHDDMYIT 833
               ||..|      .|:|::|:.|.....||.:|.:  .|.|.   |...:|:..|.:..:...:
Human   818 ---GNGTPVTSKGGDYFVFYSHGLQASAWQFWIEVQVSEEHPE---GMVTVAIAAHYLSGEDKRS 876

  Fly   834 EDFREFLATFPPWAHVSSWLGSYN 857
            .........||.|...|:|:.:|:
Human   877 PQLDALKEKFPDWTFPSAWVCTYD 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	146/309 (47%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	40/215 (19%)
ERMP1	NP_079172.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65
ERMP1	NP_079172.2	M28_Fxna_like	104..412	CDD:193497	146/309 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145822
Domainoid	1	1.000	238	1.000	Domainoid score	I2299
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1816
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm40549
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770