DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9416 and AgaP_AGAP003422

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_001688330.2	Gene:	AgaP_AGAP003422 / 5667624	VectorBaseID:	AGAP003422	Length:	904	Species:	Anopheles gambiae

Alignment Length:	871	Identity:	292/871 - (33%)
Similarity:	455/871 - (52%)	Gaps:	71/871 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LFVSCWFLLFYLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQV 88
            |.:.|..:..||...     :|:..|..|..:.|..||.|||.:.|..|:..|||..||.|||..
Mosquito    48 LLLFCGTVSSYLCTY-----LPEALTAADLDRHPTAFIAERAWDNLQVLNDFGPKPTGSRANELG 107

  Fly    89 AVQFLLSEIGDIIDDARTDLYD---IEKDVQVASGNYLLWSMVN----VYQSIQNVVVKLSPKNA 146
            |..::..|    |:.|:...:.   :|...|..||.|.:..:.|    ||::.||:||:|:.::.
Mosquito   108 AADYIRRE----IEKAKATAHAAQLVETAHQTISGAYPIAFLGNPLTSVYRNAQNLVVRLAGRSE 168

  Fly   147 TSE-AALLINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGS 210
            ..| |||::|.|:|:|..|.||.|.|..|.:|||:|||:::......:|:|||||||||.|||.:
Mosquito   169 DGERAALMLNCHYDTVASSPGASDDGGSCAVMLEILRVLSRAPQRNRHSIVFLFNGAEETPLQAA 233

  Fly   211 HAFITQHPWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGF 275
            |.|::||.||..:||.:||:||||||:|.|||:||.||||::.||:.:.||.|.|:.||:||:|.
Mosquito   234 HGFVSQHRWAGEVRAFLNLESAGSGGKEQLFQAGPQHPWLIEAYGRAVRHPAAQTVSEEIFQSGI 298

  Fly   276 VPSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANAEEL 340
            :||:||:|:|||:||:||:|.|.|:|||.|||::|..:.:.....|.||:|||||.:.|||.|||
Mosquito   299 IPSDTDFRIFRDFGHVPGMDFAHTINGYRYHTRFDTIDYLTLPVLQRTGDNILALTRELANGEEL 363

  Fly   341 ----ENPSKYAEGHMIFFDMMGWFFVYYPETTGIIINITVCVLVCVTIVLYIWMMSSSTGMFRRR 401
                .:|: .|||:.:|||::|.|||.|..:||.|:|:.:.||.....::.:.......|  .|.
Mosquito   364 GRVGSDPN-LAEGYSVFFDVLGLFFVSYSASTGQIVNVMLAVLSLAVPLMELCRQVRRVG--ERS 425

  Fly   402 IWAK--FGILAALQLAGVALGIGLVISIALFLDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIVPA 464
            :.::  .|:|..  :.|.|..:|:|:.:|..||||...|||||..:::.|||.||:|........
Mosquito   426 VLSQTLVGLLGT--VCGTAASVGVVLLVANRLDAVGRAMSWFSTPYLILGLYGCPVILMHCFAHR 488

  Fly   465 I---YFSRTKEHGLPLGYGIQLLMHSHCLILTIITAIMVSYSIRSAFVIMLCIGFYTLSVLINLV 526
            :   :||..|. .|.|...::..:.......|::...:...:||||::|.:.:....||.::..|
Mosquito   489 LCSHWFSDNKS-PLNLTQTVRARLIGVNFFWTLLIIPLTLANIRSAYIIAVIVLLSLLSTILTSV 552

  Fly   527 TKAHKTNFLWLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGR-ECNTNPEILMGFFTALMVLLFA 590
            .........||..|...|:...::.|...:....:|||:.|| ...||||.|:....|...||..
Mosquito   553 LGYQGQPRRWLALHLAFQIPTLLWATKFYHLLVKLFVPITGRMGAGTNPEYLIALLVACFGLLCV 617

  Fly   591 PFLVPLFCLFR-KSKTIISMFGICTIVFIIFAATPIAFPYAEKT----APQRFFAVHTARTFHNG 650
            .:||||..|.: .|:....|.....|.|::...|.:.|||.:::    :.||.:..||.:..|..
Mosquito   618 SYLVPLVGLLKGTSELTARMTVFAMIAFLLGCCTQVGFPYRDESNGEPSVQRHYVTHTLQVAHRD 682

  Fly   651 DPASTVSHKDSGYFVLPVDRRPHTVDDILFENTNFTKSERID-CDSELMCGFPIYSSRWLNAVDN 714
               ..|..:.:|:....:||....|...:.:........::: |.:.|.||.|.||. |.....|
Mosquito   683 ---GAVVSEGAGFLFREMDRNAVRVIRGVAKPAEAVPMRQMETCRTMLFCGVPFYSI-WHQIRFN 743

  Fly   715 SYFVPGPEP--NREYIPTLTILEKSSNSDTNIRFDLEISGPDHT----SIFILPLNDSKLVDWSF 773
            :|::.||.|  .:..:||..::....||.:..::..||.....|    ::.|.|....:|||||
Mosquito   744 NYWMEGPSPAIEKHTLPTFELVRVHQNSSSVRQYSFEIVHRHQTCVQSALIIAPKPGVQLVDWS- 807

  Fly   774 IRDPLDGNVK----PPYYVYWSYAL-DPKPLQFSLEFEHEDPNWSGGTFKIALMGHRIHDDMYI- 832
            :.|.:.|.:|    ..::|..:|.| |..|...:..||::..:...|.      |.::.|..::
Mosquito   808 LMDTVPGTIKFNGERAHFVLITYGLADDAPWTVTFAFEYDPEHLQDGA------GAKLFDVSWVN 866

  Fly   833 ---------TEDFREFLATFPPWAHV 849
                     |::||:.:..||.||||
Mosquito   867 TYWEHGDKHTDEFRKLIDQFPEWAHV 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	150/318 (47%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	58/205 (28%)
AgaP_AGAP003422	XP_001688330.2	M28_Fxna_like	76..390	CDD:193497	150/318 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	248	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
TreeFam	0	0.000	Not matched by this tool.
	7	6.830