DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9416 and NAALADL2

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_011510914.1	Gene:	NAALADL2 / 254827	HGNCID:	23219	Length:	805	Species:	Homo sapiens

Alignment Length:	329	Identity:	65/329 - (19%)
Similarity:	115/329 - (34%)	Gaps:	96/329 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 GRECNTNPEILMGFFTALMVLL---FAPFLVPLFCL-----------------FRK--SKTIISM 609
            |:|..::..|:..|..|||..:   :.|....:||.                 |:|  .|.:::.
Human   470 GQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAY 534

  Fly   610 FGICTIVFIIFAATPIAFPYAEKTAPQR--FFAVHTARTFHNGDPASTVS----HKDSGYFV--- 665
            ..:.:.:....:..|:|.|..::...::  |.....|:.     |.:.:|    ..|:.||:
Human   535 ISLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQC-----PETNISSIQIQGDADYFINHL 594

  Fly   666 -LPVDR----------RPHTVDDILFENTNFTKSERIDCDSEL--------------MCGFPIYS 705
             :|:.:          .|..:.:..| :|..||.|.:|....|              :...|:..
Human   595 GVPIVQFAYEDIKTLEGPSFLSEARF-STRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLP 658

  Fly   706 SRWLNAVDNSYFV----PGPEPNREYIPTLTILEKSSNSDTNIRFDLEISGPDHTSIFILPLNDS 766
               .||:|.:..|    .|.:||...:..:.:         .:|...|:...|.    :.|.||.
Human   659 ---FNALDIALEVQNNLKGDQPNTHQLLAMAL---------RLRESAELFQSDE----MRPANDP 707

  Fly   767 K---LVDWSFIRDPLDGNVK--------PPYYVYWSYALDPKPLQFSL---EFEHEDPNWSGGTF 817
            |   .:....:.|.|....|        |.:|....|.||.|..:||:   .:||..|..|..|.
Human   708 KERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETL 772

  Fly   818 KIAL 821
            :.||
Human   773 QEAL 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	13/78 (17%)
NAALADL2	XP_011510914.1	Peptidases_S8_S53	268..420	CDD:299169
		Zinc_peptidase_like	437..659	CDD:301362	33/197 (17%)
		TFR_dimer	686..>744	CDD:282153	12/70 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900