DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9416 and FOLH1

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_016872921.1	Gene:	FOLH1 / 2346	HGNCID:	3788	Length:	805	Species:	Homo sapiens

Alignment Length:	378	Identity:	82/378 - (21%)
Similarity:	132/378 - (34%)	Gaps:	97/378 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIG-PKVVGSAANEQVAVQFLLSEIG-DII 101
            |:.:..|.:|:..|....||   |......:|.|:..| |...|..|||....:.:...:| ..|
Human   286 PADYFAPGVKSYPDGWNLPG---GGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSI 347

  Fly   102 DDARTDLYDIEKDVQVA------------------------SGNYLLWSM------VNVYQSIQN 136
            .......||.:|.::..                        :||:....:      .|....|.|
Human   348 PVHPIGYYDAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYN 412

  Fly   137 VVVKLSPKNATS-EAALLINSHFDS-----VPGSSGAGDAGMMCVIMLEVLR---VITKYETPLT 192
            |:..|  :.|.. :..:::..|.||     :...|||       .::.|::|   .:.|......
Human   413 VIGTL--RGAVEPDRYVILGGHRDSWVFGGIDPQSGA-------AVVHEIVRSFGTLKKEGWRPR 468

  Fly   193 YSVVFLFNGAEENPLQGSHAFITQHPWA-QNIR-------AVINLDSAGSGGREILFQSGPDHPW 249
            .:::|....|||..|.||    |:  || :|.|       |.||.||:..|...:.....|....
Human   469 RTILFASWDAEEFGLLGS----TE--WAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYS 527

  Fly   250 LMKYYGKNIVHPFASTIGEELFQN----------------GFVPSETDYRVFRDYGHIPGLDMAQ 298
            |:....|.:..|.....|:.|:::                ..:.|..|:.||.....|.......
Human   528 LVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARY 592

  Fly   299 TLN-------GY-VYHTKYDRFNLI-----PRRTYQLTGENIL-ALVKALANA 337
            |.|       || :||:.|:.:.|:     |...|.||...:. .:|..|||:
Human   593 TKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANS 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	78/360 (22%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372
FOLH1	XP_016872921.1	Zinc_peptidase_like	113..>169	CDD:301362
		PA_GCPII_like	175..401	CDD:239036	22/117 (19%)
		M28_PSMA_like	403..650	CDD:193568	60/258 (23%)
		TFR_dimer	687..802	CDD:282153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900