DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9416 and C44B7.11

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_495410.4	Gene:	C44B7.11 / 183431	WormBaseID:	WBGene00016631	Length:	895	Species:	Caenorhabditis elegans

Alignment Length:	932	Identity:	251/932 - (26%)
Similarity:	422/932 - (45%)	Gaps:	204/932 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LFYLVVI---PSFHR-MPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQF 92
            ||:||:|   ...|: :|:.|   |..|:..||..:||...|..||..|.|..||...|::....
Worm    48 LFFLVLIIGTTFLHKCLPEPK---DPNQEETQFSEKRAVKVLQELSDYGWKPAGSYNCEELTRNR 109

  Fly    93 LLSEIGDI------IDDARTDLYDIEKDVQVASGNYLL----WSMVNV-YQSIQNVVVKLSPKNA 146
            :|.|:.||      :::.|.|:     |.|..||.:.:    ...:|: |:::.||:.:|.....
Worm   110 ILKELNDIRSQNQNVENLRFDI-----DTQYVSGCFDIPAHDTEGMNICYRNVSNVMARLGKGEK 169

  Fly   147 TSEAALLINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGSH 211
            ..:.::|:|.|:||.|.|:...|....|.:|||::|:.:|....|.:.|:||||||||:.|..:|
Worm   170 KDKISVLLNCHYDSWPTSNAGSDDLSSCALMLELIRLYSKNPHLLNHDVIFLFNGAEESSLLAAH 234

  Fly   212 AFITQHPWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFV 276
            .|||||.|...|||.|||:::||||||:|||:||.:.||:..|.:..:||..|.||:|:||:|..
Worm   235 GFITQHSWRHEIRAFINLEASGSGGRELLFQAGPANQWLLNSYLEAAIHPHCSVIGQEVFQSGVY 299

  Fly   277 PSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANAEELE 341
            |.:||:|:|||:|.:||||:|...|||.:||::|....|.:.:.|..|||:.:.:..|..:..||
Worm   300 PGDTDFRIFRDHGRVPGLDLAFVQNGYWWHTEFDTAERITKGSLQRAGENVYSTLNHLLKSPYLE 364

  Fly   342 NPSKYAEGHMIFFDMMGWFFVYYPETTGIIIN-ITVCVLVCVTIVLYIWMMSSSTGMFRRRIWAK 405
            .|::||:...:|||.:|.|.:.||.:...::| :|:|.::.        :||       .|.::|
Worm   365 KPAEYADRKTVFFDFLGLFVIIYPLSIAHLVNMLTICTVIA--------LMS-------HRFYSK 414

  Fly   406 FGILAALQLAGVALGIGLVISIALFLDAVNL-------PMSWFSQNWMLFGLYFCPMIFG----M 459
             ..:..|.|....|   .:::|||.|.|:..       .:.|::::|:....|..|.::.    .
Worm   415 -TFITFLALRDYVL---TILTIALVLKAMTFMSLFTYGALRWYTRHWLALVAYGLPSVWAGISVQ 475

  Fly   460 GIVPAIYFSRTKEHGLPLGYGIQL-LMHSHCLILTIITAIMVS---YSIRSAFVIMLCIGFYTLS 520
            |::.|....:.:|.     ||..| |:|     ||:|:.|:::   |.|.|.|:..|.:    :.
Worm   476 GLLTARLAPKAREE-----YGSTLELIH-----LTLISGILLAFTYYDIASGFLFALLL----VP 526

  Fly   521 VLINLVTKAHKTNFLWLIPHC------ICQVLPFMFYTYCCYAFYV------VFVPMQGRECNTN 573
            .:.:::|      :....|.|      :..:|.|   ..|..|.|.      :|:|:.||. :.|
Worm   527 AIKSIIT------YFGAWPTCPTFNTILTLILSF---PGCAMAIYTTEMLLSIFIPIMGRS-SYN 581

  Fly   574 PEILMGFFTALMVLLFAPFLVPLFCLFRKSKT---------IISMFGICTI------VFIIFAAT 623
            ||..:.||.|.........|..|....|.|::         |.::.|:..:      ||..|..:
Worm   582 PEPAVSFFVAFSAGCIVLSLGGLVAKSRNSRSSNEAGLLELIYNILGVLLVTLTILYVFSSFWPS 646

  Fly   624 PIAF----PYAEKTAPQRFFAVHTARTFHNGDPASTVSHKDSGYFVLPVDRRPHTVDDILF--EN 682
            |..|    |.|::|   :||.|:......||.    :|..|:.::.:..|.|  ..:||.|  ::
Worm   647 PYRFDNVYPTAKRT---QFFHVNQMLYDRNGQ----ISVNDTRFYAISHDYR--GAEDIPFVKKD 702

  Fly   683 TNFTKSERIDC--DSELMCGFP-IYSSRW--------LNAVDNSYFVPGPEPNREYIPTLTILEK 736
            ..:|   .:.|  ::...|..| ::.::.        :.:||.......|      :..|.|.::
Worm   703 PEYT---GLQCHYENNPWCETPFLFPTKGRLNERNIRVRSVDERLKFKHP------VKILGISKR 758

  Fly   737 ----SSNSDTNIRFDLEISGPDHTSIFILPLNDSKLVDWSFIRDPLDGNVKPP------YYV--- 788
                |.:...||.:...:.|....|::|:| :.:.|:..:.:..|     |.|      ||.
Worm   759 HGVDSKDGKGNIEYSFSVIGTGQISVYIIP-DTTWLITNTSVTQP-----KTPQENMFLYYTCST 817

  Fly   789 -----YWSYAL----------DPKPLQFSLEFEHEDPNWSGGTFKIALMGHRIHDDMYITEDFRE 838
                 .|.:.:          |.|||                  .|.:..|.:|.....:|..:.
Worm   818 PNNICEWMFKVTIKKTTQTPSDDKPL------------------LIGISSHYLHGPEMQSESIKN 864

  Fly   839 FLATF-------PPW-AHVSSW 852
            .:|..       |.| ...|:|
Worm   865 MIAKIQENRVNSPEWTVTASAW 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	123/317 (39%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	53/242 (22%)
C44B7.11	NP_495410.4	M28_Fxna_like	75..387	CDD:193497	123/316 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I1390
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		mtm4849
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.810