DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9416 and AgaP_AGAP003078

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_003436385.1	Gene:	AgaP_AGAP003078 / 1273752	VectorBaseID:	AGAP003078	Length:	886	Species:	Anopheles gambiae

Alignment Length:	911	Identity:	322/911 - (35%)
Similarity:	480/911 - (52%)	Gaps:	89/911 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KSKYENMKII-----YNRSKIGWYWAPLFVSCWF----LLFYLVV----------IPSFHRMPQL 47
            |.|:..:|::     |:::|     :...:|.|:    :...|||          :|...|...|
Mosquito    10 KQKHPKVKVLDPDIDYSKAK-----SVHSISSWWGIGGIFIVLVVGNITNYTNSHLPDGLRNAHL 69

  Fly    48 KTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEIGDIIDDARTDLYDIE 112
            ...      |..||.|||...|..|:..|||..|:..||.:||.||..|| ..||..:.....:.
Mosquito    70 THF------PAAFIAERAWKDLKILNDFGPKPTGTYTNEVLAVDFLNREI-SYIDQLKNRNQQLV 127

  Fly   113 KDVQVASGN----YLLWSMVNVYQSIQNVVVKLSPKN-ATSEAALLINSHFDSVPGSSGAGDAGM 172
            ...|:.||.    |:..|..|||:::|||||||..:: :||..|||:|.|||||.||.||.|...
Mosquito   128 VQNQIVSGGYVGVYMNKSAANVYRNVQNVVVKLVGRSESTSRHALLLNCHFDSVAGSPGASDDSG 192

  Fly   173 MCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHPWAQNIRAVINLDSAGSGGR 237
            .|.:|||||||:::......||::||||||||.|||.||.|||:||||.::||.|||:||||||:
Mosquito   193 SCAVMLEVLRVLSRQSDVNRYSIIFLFNGAEETPLQASHGFITKHPWAADVRAFINLESAGSGGK 257

  Fly   238 EILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETDYRVFRDYGHIPGLDMAQTLNG 302
            |:||||||.||||::.|.:.:.||:|....||:||:|.:||:||:|||||.|.|||:|.|.|.||
Mosquito   258 EMLFQSGPKHPWLIEAYARAVPHPYAQAAAEEIFQSGVIPSDTDFRVFRDVGRIPGMDFAHTANG 322

  Fly   303 YVYHTKYDRFNLIPRRTYQLTGENILALVKALANAEELENPSKYAEGHMIFFDMMGWFFVYYPET 367
            |.|||:||..:.||....|.||:|||||.:|:||.:||.:..:||:|:|:|:|.:|.|||.|...
Mosquito   323 YRYHTRYDSIDYIPLPVLQRTGDNILALTRAIANGDELGSTERYAQGYMVFYDFLGLFFVSYSAD 387

  Fly   368 TGIIINITVCVLVCVTIVLYIWMMSSSTGMFRRRIWAK--FGILAALQLAGVALGIGLVISIALF 430
            .|::||::| ||:.: |:.::.:..|::|...|:|.::  .|.||....|| |.|: |...|.|.
Mosquito   388 VGLMINLSV-VLLSI-IIPFLSLARSTSGTHGRQIRSETMTGFLATFLGAG-ASGV-LCFFIGLQ 448

  Fly   431 LDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIV----PAIYFSRTKEHGLPLGYGIQLLMHSHCLI 491
            |||:...|||:|...::.|:|.||.:....:|    ..::.|:|..  |.|...:|..::...|.
Mosquito   449 LDAIGRSMSWYSSTNLILGVYCCPALLCQCVVHLLCNRLFGSKTTP--LSLALKVQARLNGVNLF 511

  Fly   492 LTIITAIMVSYSIRSAFVIM------LCIGFYTLSVLINLVTKAHKTNFLWLIPHCICQVLPFMF 550
            ..:||..:.....|.|::.|      ||..  ||..::.|....||    ||:.|.:.|::...:
Mosquito   512 WGMITLGITFTGYRLAYIFMVLILCSLCSS--TLISMLGLQNTVHK----WLLLHMLFQIVALAW 570

  Fly   551 YTYCCYAFYVVFVPMQGR-ECNTNPEILMGFFTALMVLLFAPFLVPLFCLFRKS-KTIISMFGIC 613
            .|...:....:|||:.|| ..:.||::::|.......|....:|.||..|.:|: |.|..:..|.
Mosquito   571 STQFYHILMNMFVPITGRIGSSINPDVIVGTLATFATLFSCSYLTPLLFLLKKTDKLIGELVAIT 635

  Fly   614 TIVFIIFAATPIAFPYAEKT----APQRFFAVHTARTF--HNGDPASTVSHKDSGYFVLPVDRR- 671
            .|..::..:|.:.|||.:..    |.||.:..||.|.|  |||....|    |:|:.:..:||.
Mosquito   636 LIALVLATSTHVGFPYRDDAVKAPAVQRHYITHTVRKFYDHNGGERYT----DAGFLLQELDRNA 696

  Fly   672 PHTVDDILFENTNFTKSERIDCDSELMCGFPIYSSRWLNAVDNSYFVPGPEPNREYIPTLTILEK 736
            ..|::.|...:......|...||.||.|..|.||. |...:  :|::|||.|......|:::.||
Mosquito   697 KKTIEGIAMPDVVTPMREIPACDKELFCAIPFYSI-WHQVL--NYWLPGPAPVVRQAVTVSLREK 758

  Fly   737 SSNSDTNIRFDLEISGPDHTSIFILPLNDSKLVDWSFIRD---PLDGNVKPPYYVYWSYALDPKP 798
            ...|:...|..|.:.|....|:.|.|...|.|..||.:.:   |::.|.:..::|..:..::.:|
Mosquito   759 EQLSEHEHRLHLVLKGSFQCSLIIGPKAGSTLKRWSLLSEIPTPIEFNGQRGHFVLLTAGVESEP 823

  Fly   799 LQFSLEFEHEDPNWSGGTFKIALMG-----HRIHDDMYITEDFREFLATFPPWAHVSSWLGSYNS 858
            :..:|:..||...:.|....:.:..     |:.|     |..|...||..|.||||...:.:.||
Mosquito   824 MNITLDVRHELKKYDGPLVDLLVTTTHWEYHKEH-----TPVFNRLLARVPGWAHVVPSVAAVNS 883

  Fly   859 W 859
            :
Mosquito   884 Y 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	163/311 (52%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	56/212 (26%)
AgaP_AGAP003078	XP_003436385.1	M28_Fxna_like	73..384	CDD:193497	163/311 (52%)
AgaP_AGAP003078	XP_003436385.1	P-loop_NTPase	<374..>447	CDD:304359	26/76 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	248	1.000	Domainoid score	I4889
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
TreeFam	0	0.000	Not matched by this tool.
	6	5.930