DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9416 and AgaP_AGAP003423

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_311708.5	Gene:	AgaP_AGAP003423 / 1272796	VectorBaseID:	AGAP003423	Length:	882	Species:	Anopheles gambiae

Alignment Length:	929	Identity:	307/929 - (33%)
Similarity:	464/929 - (49%)	Gaps:	139/929 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKSKYENMKIIY--NRSKIGWY--WAPL-------FVSCWFLLFYLVVIPSFHRMPQLKTLEDER 54
            ||:|..|    |  |..::.||  |..|       .||.|          ||..:|...|..|..
Mosquito     1 MKAKESN----YDPNIHRLPWYGGWVLLALVALCGTVSYW----------SFFYLPPALTAADLA 51

  Fly    55 QQPGQFIGERAENTLLRLSKIGPKVVGSAANEQVAVQFLLSEIGDIIDDARTDLYDIEKDVQVAS 119
            |||..|.|.||.:||..|..:|||..||.|||..||:.|..|. .:|:.:......:..:.|:.|
Mosquito    52 QQPLAFNGARAWDTLTHLDALGPKTTGSRANEVRAVEVLEREF-SLINASHHPAQQVLYEKQIVS 115

  Fly   120 G----NYLLWSMVNVYQSIQNVVVKLSPKNATSEAALLINSHFDSVPGSSGAGDAGMMCVIMLEV 180
            |    |:....|.:||:.:||::|||  ..|....||::|.|||||..|.||.|....|.:|||:
Mosquito   116 GQYGINFFGSQMTSVYRRVQNLIVKL--VGAEDRHALMLNCHFDSVASSPGASDDCGSCAVMLEI 178

  Fly   181 LRVITKYETPLTYSVVFLFNGAEENPLQGSHAFITQHPWAQNIRAVINLDSAGSGGREILFQSGP 245
            |||:::......:|:|||||||||.|||.||.|||.|.||:.:||.:||:||||||:|:||||||
Mosquito   179 LRVLSRTPERNRHSIVFLFNGAEETPLQASHGFITGHRWAREVRAFLNLESAGSGGKELLFQSGP 243

  Fly   246 DHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYD 310
            .||||::.|.:.:.|||...||||:||:|.:||:||:|:|||:||:||||.|...|||.|||:||
Mosquito   244 QHPWLIEAYSRAVRHPFGQAIGEEIFQSGLIPSDTDFRIFRDFGHVPGLDFAHIFNGYRYHTRYD 308

  Fly   311 RFNLIPRRTYQLTGENILALVKALANAEELEN-PSKYAEGHMIFFDMMGWFFVYYPETTGIIINI 374
            ....:.....|.||:|||::|:.|||..:|.| ....:||.|:|||.:|.||:.|....|.::||
Mosquito   309 SVQFLSPAVLQRTGDNILSMVRLLANGNQLANRDDGQSEGSMVFFDFLGLFFISYTAIEGTVLNI 373

  Fly   375 TVCV---LVCVTIVLYIWMMSSSTGMFRRRIWAKFGILAALQLAGVALGIGLVISIALFLD-AVN 435
            .|.:   ||....||.:...|:...|.|..:   .|.:|.  |.|...||||.::.|..:| .|:
Mosquito   374 VVSIAGLLVGCWSVLAVVGWSNWRSMGREML---HGFVAT--LVGSGAGIGLNLATAYGMDRIVD 433

  Fly   436 LPMSWFSQNWMLFGLYFCPMIFGMGIVPAIY---FSRTKEHGLPLGYGIQLLMHSHCLILTIITA 497
            ..|||:|..|::.|:|..|::..:.|....:   ||::|. .|.|...:|..:....|...::|.
Mosquito   434 RSMSWYSSCWLVVGMYCVPVMMLLFIAHREFHRLFSKSKT-VLSLTLTVQARIVGVFLFWALLTI 497

  Fly   498 IMVSYSIRSAFV--IMLCIGFYTLSVLINLVTKAHKTNFLWLIPHCICQVLPFMFYTYCCYAFYV 560
            ....|.:|||:|  |||.:..:::::...|..::....: |||.:.:...:..::.|...:.|..
Mosquito   498 GATVYGLRSAYVIAIMLTLALFSMTLTALLKLQSFPGGY-WLIIYLLVHSVALLWTTQFYHIFTN 561

  Fly   561 VFVPMQGRE-CNTNPEILMGFFTALMVLLFAPFLVPLFCLFRKS-KTIISMFGICTIVFIIFAAT 623
            :|:|:.||. .|.||::::|...|...:....|||||..|.||. :||.::|.:......:...:
Mosquito   562 IFIPITGRSGANDNPDLIIGIVAAACTIFTTSFLVPLVNLLRKPYRTIGTLFVLFLAALALGTVS 626

  Fly   624 PIAFPY-----AEKTAP--QRFFAVHTARTFHNGDPASTVSHKDSGYFVLPVDR-RPHTVDDILF 680
            ...|||     :...||  ||....||.|.|:..:...||...|:||.....|| ...||.|:|.
Mosquito   627 SFGFPYTGPGSSPSDAPKVQRILVQHTVRQFYEPNSTQTVRSADAGYLFRLWDRHNERTVRDVLE 691

  Fly   681 EN------TNFTKSERIDCDSELMCGFP----IYSSRWLNAVDNSYFVPGPEPNREYIPTLT--- 732
            :.      :....:|..:|..|:.||.|    .::|.|           .|:.||...|.:.
Mosquito   692 KQSPGKGASALEPTELPECKREVFCGMPGSAIRFTSLW-----------SPQSNRPNTPDMVKLS 745

  Fly   733 -----ILEKSSNSDTNIRFDLEISGPDHTSIFILPLNDSKLVDWSFIRDPLDGNVKP-------- 784
                 ::.:::|. ::|:..:.::|...::|.:.|.::.:|..|         |:.|
Mosquito   746 LDRWEVVRRNANG-SSIKLTISLNGSFQSTILVRPRHNVRLTGW---------NLTPEVPVKLAA 800

  Fly   785 ----PYYVYWSYAL--DPKPLQFSLEFEHEDPN-------------WSGGTFKIALMGHRIHDDM 830
                .|::..::.|  :|.||...||.:.:...             |            ..|:
Mosquito   801 AGHKAYFLLITHGLAGEPVPLILDLETDRQSDTVEPLVDISVTSNFW------------EYHE-- 851

  Fly   831 YITEDFREFLATFPPWAHV 849
            :.||:|..|:|:||.||||
Mosquito   852 HFTEEFSRFVASFPSWAHV 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	150/311 (48%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	55/208 (26%)
AgaP_AGAP003423	XP_311708.5	M28_Fxna_like	56..363	CDD:193497	149/309 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	248	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
TreeFam	0	0.000	Not matched by this tool.
	7	6.830