DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9416 and AgaP_AGAP007676

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_308195.3	Gene:	AgaP_AGAP007676 / 1269552	VectorBaseID:	AGAP007676	Length:	875	Species:	Anopheles gambiae

Alignment Length:	867	Identity:	319/867 - (36%)
Similarity:	479/867 - (55%)	Gaps:	62/867 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VSCWFLL--------FYLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGS 82
            :|.|:||        .|.:|..::..||......||...|.:||.|.|:..|..:|.:||:|.||
Mosquito    22 ISPWWLLALSGAVAGVYFLVYWNWAAMPIALRRADELTHPDRFIAEVAKQHLFEMSNVGPRVAGS 86

  Fly    83 AANEQVAVQFLLSEIGDIIDDARTDLYDIEKDVQVASG----NYLLWSMVNVYQSIQNVVVKLSP 143
            .|||.|.|||||..|.:|..:|....:.:|.:||.|.|    :|..:...:|||.|||||.::.|
Mosquito    87 YANEIVTVQFLLRVIDEIAAEANPAAHRVEVEVQRAYGDMYLDYEKYPQTSVYQGIQNVVARIVP 151

  Fly   144 -KNATSEAALLINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPL 207
             :.:..:..|:::|||||||.|.||||.|.|.||||||:|.:.:.:....:.:||:|||.|||.|
Mosquito   152 AQGSDPDNYLMLSSHFDSVPQSPGAGDDGTMSVIMLEVMRQLAQGKRSYEHGLVFVFNGCEENTL 216

  Fly   208 QGSHAFITQHPWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQ 272
            ||||||:..|.|...:|..||:|.|.:|||:|:||:||.:.:||:||..::.||:.:.:.|||||
Mosquito   217 QGSHAFVAHHRWFAKVRTFINMDVAANGGRDIMFQAGPKYSFLMEYYRDHVPHPYCTAVAEELFQ 281

  Fly   273 NGFVPSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANA 337
            ...|||||||.::...|:|||:|.|.:..||:|||.||.::.||..|.|.||:|:|||.||||||
Mosquito   282 ADLVPSETDYLIYSTVGNIPGMDFAHSTWGYLYHTAYDAYDTIPNTTLQHTGDNVLALAKALANA 346

  Fly   338 EELENPSKYAEGHMIFFDMMGWFFVYYPETTGIIINITVCVLVCVTIVLYIWMMSSSTGMFRRRI 402
            .||.:..::.....:|||.:.||.||||....||:|:.:.|:....|.|.:|||:.|..:...::
Mosquito   347 PELYDIREHEGSKAVFFDFLNWFLVYYPLWASIILNVGLVVVALCAIGLSVWMMARSMSLTVGQL 411

  Fly   403 WAKFGILAALQLAGVAL-----GIGLVISIALFLDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIV 462
                 :|..|...||.|     ||||.:::|..|:||:..||||:|.|::||||.||.:......
Mosquito   412 -----LLQGLTSMGVVLLSLIVGIGLSLALAAILNAVDSTMSWFTQTWLIFGLYVCPFLIATCTG 471

  Fly   463 PAIYFSRTKEHGLPLGYGIQLLMHSHCLILTIITAIMVSYSIRSAFVIMLCIGFYTLSVLINLVT 527
            |.:|....|...|.|...:|||:|:.|::..:|..::.:.||||.::..:.|.|||::.|:|:..
Mosquito   472 PVLYIHFVKNDHLSLHARVQLLLHATCVLYALILVVLTAMSIRSGYLFTMAILFYTVTTLVNVSI 536

  Fly   528 KAHKTNFLWLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGR-ECNTNPEILMGFFTALMVLLFAP 591
            |  .:.|.||..|...|:.|..:::......:..|:||||| ....|||:|:..|..|:.||.|.
Mosquito   537 K--YSAFAWLYVHLAGQIAPIAYFSSVSLTAFATFIPMQGRGNAGANPELLIALFAVLVGLLVAG 599

  Fly   592 FLVPLFCLFRKSKTIISMFGICTIVFIIFAATPIAFPYAEKTAPQRFFAVHTARTFH--NGDPAS 654
            ||.||..|.|||...|::..:..:|.||...|...||:...|:||||:..|..|.|:  ||
Mosquito   600 FLTPLVALARKSYLYIALVAVFFVVSIIVMVTSAGFPFRAHTSPQRFYIYHCTREFYHQNG---- 660

  Fly   655 TVSHKDSGYFVLPVDRRPHTVDDILFENTNFTKSE------RIDCDSELMCGFPIYSSRWLNAVD 713
            |:...:.||:|.|.||   ...|::.|..  .||:      ..:||.||.||.|.|.:......:
Mosquito   661 TLRRLEGGYYVHPQDR---YTGDLIRELA--VKSDLSAVPLGAECDKELYCGIPFYQNTQHGQRE 720

  Fly   714 NSYFVPGPEPNREYIP---TLTILEKSSNSDTNI-RFDLEISGPDHTSIFILPLNDSKLVDWSFI 774
            |..::.|   |...:|   .|.:::...:.:.|: .|.....|.||.|.::.|:...|||.|||.
Mosquito   721 NGLWIQG---NPFTLPEAIDLQLVDSQRDPELNLTTFFFTAKGTDHMSFYVSPVEGVKLVGWSFS 782

  Fly   775 ----RDPLDGNVKPPYYVYWSYALDPKPLQFSLEF-----EHEDPNWSGGTFKIALMGHRIHDDM 830
                |..|..|.:..::|.:.:.:|.:|.:|.|..     :..:..||   |.:.::...:|.:.
Mosquito   783 KTIPRSGLAWNGQEVHFVNFVHGIDDRPHEFYLTVHGTASKAVEAGWS---FYLNIVAQYMHHEQ 844

  Fly   831 YITEDFREFLATFPPWAHVSSW 852
            |...:|::|:..||.:|||.::
Mosquito   845 YRASEFQQFVDQFPDYAHVVAY 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	146/311 (47%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	72/201 (36%)
AgaP_AGAP007676	XP_308195.3	M28_Fxna_like	61..373	CDD:193497	146/311 (47%)
AgaP_AGAP007676	XP_308195.3	SLC5-6-like_sbd	351..632	CDD:294310	99/287 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	318	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	597	1.000	Inparanoid score	I2419
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		mtm9615
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
TreeFam	1	0.960	-	-
	12	11.940