DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9416 and ermp1

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	XP_004910853.1	Gene:	ermp1 / 100145630	XenbaseID:	XB-GENE-984733	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	876	Identity:	279/876 - (31%)
Similarity:	439/876 - (50%)	Gaps:	105/876 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LLFYLVVIPSFH-RMPQLKTLEDERQQPG----QFIGERAENTLLRLSKIGPKVVGSAANEQVAV 90
            ||:.|.|....| .:.||.|       ||    .|....|...|.:::.|..::|||..||.:||
Frog    53 LLYVLGVRGLVHISLRQLVT-------PGGHSTGFNASTAREYLQQITSIDSRIVGSPENEIIAV 110

  Fly    91 QFLLSEIGDIIDDARTDLYDIEKDVQVASGNY---LLWSMVNVYQSIQNVVVKLSPKNATSEAAL 152
            .:||.:|.| |::....::.|..|||..:|.:   .|....:.|.:|.|:.|||.|:.. :|.|:
Frog   111 DYLLGKIKD-IEEKVNSVHKITVDVQRPTGTFSIDFLGGFTSYYDNITNIAVKLEPEFG-AEHAV 173

  Fly   153 LINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGSHAFITQH 217
            |.|.|||||..:.||.|..:.|.:|||:|..::....||.::::|||||||||.|||||.|||||
Frog   174 LANCHFDSVANTPGASDDAVSCAVMLEILGSLSVSSKPLRHAIIFLFNGAEENILQGSHGFITQH 238

  Fly   218 PWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPSETDY 282
            |||:.:||.|||::||.||:|::||:||::|||::.|....||||||.:.:|:||:|.:||:||:
Frog   239 PWAKMVRAFINLEAAGVGGKELVFQTGPENPWLVQAYALAAVHPFASVVAQEVFQSGIIPSDTDF 303

  Fly   283 RVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANAEELENPSKYA 347
            |::||:|:|||:|:|...|||:||||||.:|.|...:.|..|:|||.::..||.:.:|...||:.
Frog   304 RIYRDFGNIPGIDLAFIENGYIYHTKYDTWNRILTESIQRAGDNILGVLHYLATSSQLAESSKFR 368

  Fly   348 EGHMIFFDMMGWFFVYYPETTGIIIN-ITVCVLVCVTIVLYIWMMSSSTGMFRRRIWAKFGILAA 411
            .|:|:|||:.|.|.:.||...|.||| ||..|.:.......|......|...|..:   :|.|
Frog   369 HGNMVFFDVCGLFVLSYPARLGTIINYITAAVTLFYIGKKIIKYKQGGTNYARDLV---YGFL-- 428

  Fly   412 LQLAGVALGIGLVISIALFLDAVNLPMSWFSQNWMLFGLY----FCPMIFGMGIVPAIYFSRTKE 472
            :.|......:..|:.||:.:......:.|::..::...||    ...:|....:....:|:....
Frog   429 ITLVSWVSALVTVLIIAVLVSLAGKALFWYTHFYVSVFLYGSAAVAKLILVHSLAKTFFFAGASS 493

  Fly   473 HGL-PLGYGIQLLMHSHCLILTIITAIMVSYSIRSAFVIMLCIGFYTLSVLINLVTKAHKTNFLW 536
            ..| .:.:.|.|::  .|:.|.::|    ...:.||:       |:...::..|:||      |.
Frog   494 QYLGDVFFDISLII--WCIPLVLLT----QSGLCSAY-------FFAAWIIFPLLTK------LL 539

  Fly   537 LIPHCICQVLPFMF-----------YTYCCY---AFYVVFVPMQGRE-CNTNPEILMGFFTALMV 586
            |.|..|.|..|:.|           |.:..|   |.:.:|.|:.||. ....|::::||......
Frog   540 LQPDIIHQGSPYKFTVIYLLGLFPPYLHTMYHVWAVFEMFTPILGRSGTEIPPDVVLGFLIIACT 604

  Fly   587 LLFAPFLVPLFCLFRKSKTIISMFGICTIVFIIFAATPIAFPYAEKT---APQRFFAVHTARTFH 648
            ::...:.:....|.:.:|.||....:.:::..:...:.:.|||:..|   .|:|.|..||.||||
Frog   605 IMLISYFISFIYLVKNTKNIIVPLAVLSVLTFLLVCSGMFFPYSSSTDSPKPKRIFLQHTTRTFH 669

  Fly   649 N--GDPASTVSHKDSGYFVLPVDR------RPHTVDDILFENTNFTKSERIDCDSELMCGFPIYS 705
            :  |:    |..||||.::...|.      .||      |...|.|  .|..||...:||||
Frog   670 SLTGE----VVKKDSGIWINGFDYTGISHVTPH------FPELNDT--VRAPCDDAPLCGFP--- 719

  Fly   706 SRWL----NAVDNSYFVPGPEPNREYIPT---LTILEKSSNSDTNIRFDLEISGPDHTSIFILPL 763
              |.    |.:..::::|.| |...|..|   |...|:.|...|.:.|  |..||.|.::::.|.
Frog   720 --WYFPVHNLIRKNWYLPAP-PAPIYEHTEFKLVSREEMSWGTTRLHF--EAKGPSHMTVYVRPH 779

  Fly   764 NDSKLVDWSFIRD--PLDGNVKPPYYVYWSYALDPKPLQFSLEFEHEDPNWSGGTFKIALMGHRI 826
            .||.|..|| :.|  |:....| .|::::|:.|.....:|.:|.:: ..:.|.|...:|:..|..
Frog   780 ADSVLSSWS-LGDGIPIASGEK-DYFIFYSHGLYAPAWKFWIEVKN-SADESKGIVTVAVGSHYF 841

  Fly   827 HDDMYITEDFREFLATFPPWAHVSSWLGSYN 857
            ..|...:...:.....||.|:..|||:.:|:
Frog   842 FGDSRNSPHLKTVELKFPDWSFPSSWVCTYD 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	141/313 (45%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	41/220 (19%)
ermp1	XP_004910853.1	M28_Fxna_like	78..385	CDD:349872	139/308 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2323
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1875
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm47728
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090