DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9416 and NAALADL1

DIOPT Version :9

Sequence 1:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster
Sequence 2:	NP_005459.2	Gene:	NAALADL1 / 10004	HGNCID:	23536	Length:	740	Species:	Homo sapiens

Alignment Length:	367	Identity:	80/367 - (21%)
Similarity:	127/367 - (34%)	Gaps:	115/367 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WYWAPLFV--SCWFLLF------YLVVIPSFHRMPQLKTLEDERQQPGQFIG-ERAENTLLRLS- 73
            ||..|..|  ..::..|      ||..:||..|: .|..:......|.|.|| :.|.:.|..|:
Human   237 WYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRV-DLANVSGFPPIPTQPIGFQDARDLLCNLNG 300

  Fly    74 ---------------KIGPKVVGSAANEQVAVQFLLSEIGDIIDDARTDLYDIEKDVQVASGNYL 123
                           ::||                         ..|.|            |::.
Human   301 TLAPATWQGALGCHYRLGP-------------------------GFRPD------------GDFP 328

  Fly   124 LWSMVNVYQSIQNVVVKLSPKNATS-----------EAALLINSHFDSVPGSSGAGDAGMMCVIM 177
            ..|.|||  |:.|   :|..:|:::           :..:|..:|.||  ...||.|......::
Human   329 ADSQVNV--SVYN---RLELRNSSNVLGIIRGAVEPDRYVLYGNHRDS--WVHGAVDPSSGTAVL 386

  Fly   178 LEVLRVITKYETPLTY----SVVFLFNGAEENPLQGSHAFITQ--HPWAQNIRAVINLDSAGSGG 236
            ||:.||:.......|:    |:||...||||..|.||..|..:  :...:...|.||:|.:....
Human   387 LELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAYINVDISVFAN 451

  Fly   237 REILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQN------------GFVPS------ETDYR 283
            ..:..|..|....::....|.|..|....:  .::.|            |.|||      .:||.
Human   452 ATLRVQGTPPVQSVVFSATKEIRSPGPGDL--SIYDNWIRYFNRSSPVYGLVPSLGSLGAGSDYA 514

  Fly   284 VFRDYGHIPGLDMAQTLNGY--------VYHTKYDRFNLIPR 317
            .|..:..|..:|:|.|.:..        .|||.:|.|:.:.:
Human   515 PFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	69/321 (21%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372
NAALADL1	NP_005459.2	Zinc_peptidase_like	46..>121	CDD:387401
		PA_GCPII_like	109..335	CDD:239036	25/135 (19%)
		M28_PSMA_like	<348..587	CDD:349942	49/213 (23%)
		TFR_dimer	616..735	CDD:367885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900