DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and TRE1

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_015149.1	Gene:	TRE1 / 855927	SGDID:	S000006097	Length:	783	Species:	Saccharomyces cerevisiae

Alignment Length:	815	Identity:	144/815 - (17%)
Similarity:	248/815 - (30%)	Gaps:	319/815 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 KMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNVVVKIS 147
            |..|| |......:.||:..:|     .:||..||.|.:|.|...|:.|.:      .:..::..
Yeast   134 KARGS-NGSFSDHDLLLQYARK-----SIDLSKIERDLEYISSMPHMSGTS------GDAAIRHY 186

  Fly   148 QKSSDNENYL--------LVNSHYDSEVQTPAAGDD---GVMVVVMLETLRVISRSERTLTHPVV 201
            .|.|.::|.:        :..|:|...|.......|   |..:.:..|....:|.:.:....||:
Yeast   187 IKESFDKNGIRLAGEEEFMAYSNYPGNVSLRVYSKDDTEGFDIPLNEENFNPMSHNGQLNNIPVI 251

  Fly   202 F----------------LFNGAEEACMLGSHG------FITQHKWSKNCKALVNLDSTGAGGREV 244
            :                |.||  :..:|..:|      .:|..::  ..||::.:.......::|
Yeast   252 YANKASLDDMASMQDQGLLNG--DFILLVHYGDYVFQQMLTAQEY--GAKAIIFISEPYQDNKDV 312

  Fly   245 L---------FQTGPNHPWLAKYYQASVPHPYAQTLAEELFQHNFIP-----SDTDFRIFRDYGG 295
            :         :.||..   |...::.|:..|...|.|:.|.:...||     .|....|..|.|
Yeast   313 IQMKSVALPQYGTGDA---LTPEWEGSIRDPIDATEAKCLPKIPSIPISANQGDKILAILSDTG- 373

  Fly   296 VPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWALANAPELDNTTAYEKGHTVYYD 360
                            .:|.|  |:..|:......::|.             .||..:.|.| :|
Yeast   374 ----------------VKFSN--NLFSGSLNDCRLDLLV-------------QTAIRERHPV-HD 406

  Fly   361 FLGWFMMTYTESVSIAINVVVSVAAFICIGTSVYIMTLDNGADAPKAVVL---RFAIIFLVQAGT 422
            .:|                                 .::....|.:|:|:   |.:..:    ||
Yeast   407 IVG---------------------------------KIEGSEQAGRAIVIAAPRNSASY----GT 434

  Fly   423 LFVACGLTLLVAVFMQGVGLAESWYYGKWMAF-GLYFCTLFFAFGILPATYIGFT---KRKTNMK 483
            ::.:.|..:|:::...   ..|..|...|... .:|    |.:||.......|.|   :::|.
Yeast   435 MYPSFGTVVLLSLIQL---YQEMVYKFDWKPLRNIY----FISFGGSEFNEAGATELMEKRTE-- 490

  Fly   484 LDQTIACFMHAQCILLALLCIIMTIMGIRSSYFPMVGIF-------FYAISVLVQIVLKLTLKKS 541
                            ||...|.||:.:     ..:||:       .....:||.:..|....:.
Yeast   491 ----------------ALKSEIYTIIDV-----GQIGIWDDSNNLEIQCHPLLVDLFQKNMTSRK 534

  Fly   542 YFVTVHLLFQVLPFFFYT-YICYATLVTFVPMEGRDGPESSPDIMISVFIIATAINYAGFVIPIM 605
            :.|.|..:.|   |..:| |:.....|..:         |||.:|.....|.|..:...|   |.
Yeast   535 FNVKVDNVHQ---FGDWTPYLAQGIPVAII---------SSPGVMNREHPIYTVEDKFDF---IK 584

  Fly   606 HKFRKPK-----------IIFSSFGVITIIFIILACTSAGFPFVKQLAPQRYYVLHTQRTFHNLD 659
            .|.|..|           ::..|..:|...||         ||                :..|
Yeast   585 DKLRDKKKGEVLSEIMLYLVEKSLELIDDPFI---------PF----------------SISN-- 622

  Fly   660 GTSKQDSGYYIQPVDTRLHEL-----DDTTFKNAEPESWTAATCAAEPYCGLPLYSG---RWIEW 716
                     |:..:.|.|.:|     |...|.              |.:.|..|:..   ::.:|
Yeast   623 ---------YVDFLSTTLKDLQKECPDTVNFD--------------EVFLGTTLWENTKLQFEKW 664

  Fly   717 KDSARW--------IYSSPPVIPMN----------INLTQLSKQSLDGNKVRYEYNLRASDRVM- 762
            |  :.|        .|..|.:|.:|          |.:||..::.|             .||..
Yeast   665 K--SEWTELMYGAGTYIEPTIIAINRWSWNYLLSLIGVTQCLEEGL-------------MDRTFY 714

  Fly   763 --------MYI---DPL---------DNVKVTDWS 777
                    :::   |||         |.:.:.|||
Yeast   715 KNVIFGPKLWVDKGDPLRSWTFPEIRDTIAIKDWS 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	62/332 (19%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	43/257 (17%)
TRE1	NP_015149.1	PA	221..374	CDD:333703	29/176 (16%)
		M28_PMSA_TfR_like	402..617	CDD:349871	54/306 (18%)
		TFR_dimer	642..769	CDD:398094	24/137 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900