DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and TFRC

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens

Alignment Length:	576	Identity:	124/576 - (21%)
Similarity:	185/576 - (32%)	Gaps:	188/576 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 NFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNV-----VVKISQKSSDNEN 155
            :::.||....||| .|.||   |:.|:..            ..||.|     .|||..|.|...:
Human   151 SYVPREAGSQKDE-NLALY---VENQFRE------------FKLSKVWRDQHFVKIQVKDSAQNS 199

  Fly   156 YLLV--NSHYDSEVQTP--------AAGDDGVMVVVMLETLRVISRSERTLTHPVVFLFNGAEEA 210
            .::|  |......|:.|        ||...|.:|.....|    .:....|..||    ||:...
Human   200 VIIVDKNGRLVYLVENPGGYVAYSKAATVTGKLVHANFGT----KKDFEDLYTPV----NGSIVI 256

  Fly   211 CMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAE-E 274
            ...|...|         .:.:.|.:|..|.|  ||.            |......|...  || .
Human   257 VRAGKITF---------AEKVANAESLNAIG--VLI------------YMDQTKFPIVN--AELS 296

  Fly   275 LFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWAL 339
            .|.|                       |.:..|..|...|.:|.:.::...:|:|         |
Human   297 FFGH-----------------------AHLGTGDPYTPGFPSFNHTQFPPSRSSG---------L 329

  Fly   340 ANAP-ELDNTTAYEKGHTVYYDFLG-----W-----FMMTYTESVSIAI---NVVVSVAAFICIG 390
            .|.| :..:..|.||   ::.:..|     |     ..|..:||.::.:   ||:..:......|
Human   330 PNIPVQTISRAAAEK---LFGNMEGDCPSDWKTDSTCRMVTSESKNVKLTVSNVLKEIKILNIFG 391

  Fly   391 TSVYIMTLDN-----------GADAPK-----AVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQG 439
            .....:..|:           |..|.|     |::|:.|.:|...               |...|
Human   392 VIKGFVEPDHYVVVGAQRDAWGPGAAKSGVGTALLLKLAQMFSDM---------------VLKDG 441

  Fly   440 VGLAESWYYGKWMA--FGLYFCTLFFAFGILPATYIGFTKRKTNMKLDQTI---ACFMHAQCILL 499
            ...:.|..:..|.|  ||....|.:.. |.|.:.::   |..|.:.||:.:   :.|..:...||
Human   442 FQPSRSIIFASWSAGDFGSVGATEWLE-GYLSSLHL---KAFTYINLDKAVLGTSNFKVSASPLL 502

  Fly   500 ALLCIIMTIMGIRSSYFPMVGIFFYAISVLVQIVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYA 564
            ..| |..|:..::   .|:.|.|.|..|.....|.||||..:.|          ||..|:.|
Human   503 YTL-IEKTMQNVK---HPVTGQFLYQDSNWASKVEKLTLDNAAF----------PFLAYSGI--- 550

  Fly   565 TLVTFVPMEGRDGP-------------ESSPDIMISVFIIATAINYAG-FVIPIMH 606
            ..|:|...|..|.|             |..|::.   .:...|...|| |||.:.|
Human   551 PAVSFCFCEDTDYPYLGTTMDTYKELIERIPELN---KVARAAAEVAGQFVIKLTH 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	62/299 (21%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	64/290 (22%)
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	46/243 (19%)
		M28_TfR	385..610	CDD:193572	58/258 (22%)
		Ligand-binding	569..760		9/38 (24%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900