DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10051 and Tfrc

DIOPT Version :9

Sequence 1:NP_611414.1 Gene:CG10051 / 37222 FlyBaseID:FBgn0034437 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_073203.1 Gene:Tfrc / 64678 RGDID:70488 Length:761 Species:Rattus norvegicus


Alignment Length:765 Identity:134/765 - (17%)
Similarity:258/765 - (33%) Gaps:214/765 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DITEEKDGGKSRDKKWP--WFGAPIYAAAAFALFY-AAVLPSFYSYPKMLYQSEEALH-PDKFIG 67
            |..|..|.......:.|  :.|...:|..|..:|: ...:..:..|.|.:.|.||.:. .:....
  Rat    43 DEEENADSNMKASVRKPKRFNGRLCFATIAVVIFFLIGFMIGYLGYCKRVEQKEECVRLAEAEEA 107

  Fly    68 ERAMRQLAEYSAIGNKMSGS-----INNEVHTINF------------LLREIQKIKDEARLDLYD 115
            :::.....||....:::..:     ::.::::|.|            ..||....|||..     
  Rat   108 DKSENDETEYVPKSSRLFWADLKTLLSEKLNSIEFTDIIKQLSQNTYTPREAGSQKDENL----- 167

  Fly   116 IEVDTQYSSGAFH------LWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSE-VQTP--- 170
                ..|....||      :|        .....|||..|:|.::|.:.:||..:.: |:.|   
  Rat   168 ----AYYIENLFHDFKFSKVW--------RDEHYVKIQVKNSVSQNLVTINSGSNIDPVEAPEGY 220

  Fly   171 ----AAGD-DGVMVVVMLETLRVISRSERTLTHPVVFLFNG----AEEACMLGSHGFI-TQHKWS 225
                .||: .|.:|.....|.:.......::...:|.:..|    ||:.....|...| ......
  Rat   221 VAFSKAGEVTGKLVHANFGTKKDFEELNYSVNGSLVIVRAGKITFAEKVANAQSFNAIGVLIYMD 285

  Fly   226 KNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAEELFQH-NFIPSDTDFRI 289
            :|...:|..|....|...:    |...|     |....|.          |.| .|.||.:    
  Rat   286 RNTFPVVEADLQFFGHAHL----GTGDP-----YTPGFPS----------FNHTQFPPSQS---- 327

  Fly   290 FRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWALANAPELDNTTAYEKG 354
                .|:|.:.:.::........    |||:         |...|..|.:.::.:|:        
  Rat   328 ----SGLPSIPVQTISRAAAEKL----FKNM---------EGNCPPSWNIDSSCKLE-------- 367

  Fly   355 HTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSVYIMTLDNGADAPKAVVLRFAIIFLVQ 419
                        ::..::|.:.:|.|:.....:      .|..:..|.:.|.    |:.::...:
  Rat   368 ------------LSQNQNVKLTVNNVLKETRIL------NIFGVIKGYEEPD----RYIVVGAQR 410

  Fly   420 ------AGTLFVACGLTLLVA------VFMQGVGLAESWYYGKWMA--FGLYFCTLFFAFGILPA 470
                  .....|..||.|.:|      :...|...:.|..:..|.|  :|....|.:.. |.|.:
  Rat   411 DAWGPGVAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSIIFASWTAGDYGAVGATEWLE-GYLSS 474

  Fly   471 TYIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMG--IRSSYFPMVGIFFYAISVLVQIV 533
            .::   |..|.:.||:.:   :......::...::.|:||  ::....|:.|.:.|..|..:..:
  Rat   475 LHL---KAFTYINLDKVV---LGTSNFKVSASPLLYTLMGKIMQDVKHPIDGKYLYRDSNWISKI 533

  Fly   534 LKLTLKKSYFVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDGPE-----SSPDIMISVF---- 589
            .:|:|..:.|          ||..|:.|   ..|:|...|..|.|.     .:.:|:|...    
  Rat   534 EELSLDNAAF----------PFLAYSGI---PAVSFCFCEDEDYPYLGTKLDTYEILIQKVPQLN 585

  Fly   590 -IIATAINYAG-FVIPIMHKFRKPKIIFSSFGVITIIFIILACTSAGFPFVKQL----------- 641
             ::.||...|| |:|.:.|...           :|:.:.:.  .|....|:|.|           
  Rat   586 QMVRTAAEVAGQFIIKLTHDIE-----------LTLDYEMY--NSKLLSFMKDLNQFKADIKDMG 637

  Fly   642 -------APQRYYVLHTQR---TFHNLDGTSKQDSGYYIQPVDTRLHELD 681
                   :.:..|...|.|   .|||.:.|::    :.::.::.|:.:::
  Rat   638 LSLQWLYSARGDYFRATSRLTTDFHNAEKTNR----FVMREINDRIMKVE 683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10051NP_611414.1 M28_Fxna_like 62..369 CDD:193497 56/344 (16%)
MATE_like 361..>604 CDD:298879 51/269 (19%)
TfrcNP_073203.1 Mediates interaction with SH3BP4. /evidence=ECO:0000250|UniProtKB:P02786 1..67 5/23 (22%)
Endocytosis signal. /evidence=ECO:0000250|UniProtKB:P02786 20..23
Stop-transfer sequence. /evidence=ECO:0000250|UniProtKB:P02786 58..61 1/2 (50%)
PA_TfR 201..378 CDD:239043 39/236 (17%)
M28_TfR 386..611 CDD:349946 50/265 (19%)
Ligand-binding. /evidence=ECO:0000250 570..761 22/131 (17%)
TFR_dimer 638..751 CDD:398094 8/50 (16%)
Cell attachment site, required for binding to transferrin. /evidence=ECO:0000250|UniProtKB:P02786 647..649 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2234
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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