DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and naalad2

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_956571.1	Gene:	naalad2 / 393247	ZFINID:	ZDB-GENE-040426-1025	Length:	745	Species:	Danio rerio

Alignment Length:	443	Identity:	80/443 - (18%)
Similarity:	150/443 - (33%)	Gaps:	137/443 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 VHTINF--LLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISY---------------TNL 139
            ||.|.|  .:..:|.:...|..|.:...::..|..|.    |.|..:               |.:
Zfish   282 VHPIGFHDAVHLLQNMGGPAPPDSWKGALNVSYRIGP----GFTDGFRQNKVRMNIHTNNQVTRI 342

  Fly   140 SNVVVKISQKSSDNENYLLVNSHYDSEV---QTPAAGDDGVMVVVMLETLRVIS-------RSER 194
            .||:..| :.:.:.:.|:::..|.|:.|   ..|.:|     ..|:.|.:|...       |..|
Zfish   343 YNVIGWI-RGAVEPDRYIILGGHRDAWVFGGIDPVSG-----AAVVHENVRAAGKLMKKGWRPRR 401

  Fly   195 TLTHPVVFLFNGAEEACMLGSHGFITQHKWSK-NCKAL-------VNLDSTGAG----------- 240
            ||    :|....|||..:.||      .:|:: |.:.|       :|.||...|
Zfish   402 TL----IFASWDAEEFGLQGS------TEWAEDNARVLQERAVAYINADSAIEGMYTLRVDCTPS 456

  Fly   241 -----------------GRE--VLFQT--------GPNHPWLAKYYQASVPHPYAQTLAEELFQH 278
                             |.|  .|:::        ..:.||::|....|....|...|.....:.
Zfish   457 LHTLVYDITKKVLSPEEGEEGMSLYESWHKRDNWPEKDKPWISKLGSGSDFEAYFIRLGITSGRA 521

  Fly   279 NFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVE------YGTYQSTGENVLPLIW 337
            .:    |..|....|...|           |||:.::.::.||      :...::.......||:
Zfish   522 RY----TKNRKTERYSSYP-----------VYHSVYETYEIVERFYDPRFRRLEAVARVRGGLIF 571

  Fly   338 ALANAPELD-NTTAYEKGHTVYYDFLGWFMMTYTESVS---IAINVVVSVAAFICIGTSVYIMTL 398
            :||::..|. :...|....:.|.:.:......:.|::.   ::.:.:.|.|....:....:...|
Zfish   572 SLADSAVLPLDCVEYATSLSTYANSIHQLAKKHPEAMQQYVVSFDSLFSAAENFTVAARDFHQRL 636

  Fly   399 DNGADAPKAVVLRFA---IIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYY 448
            |. .|:..|:.:|..   :::|.:|               |:..:||....:|
Zfish   637 DQ-LDSSNALAVRMVNDQLMYLERA---------------FIDPLGLPGRPFY 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	66/356 (19%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	14/94 (15%)
naalad2	NP_956571.1	Zinc_peptidase_like	47..>102	CDD:301362
		PA_GCPII_like	108..333	CDD:239036	11/54 (20%)
		M28_PSMA_like	341..581	CDD:193568	52/270 (19%)
		TFR_dimer	618..733	CDD:282153	13/72 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900