DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and Ermp1

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_006231303.1	Gene:	Ermp1 / 373544	RGDID:	727831	Length:	899	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	256/895 - (28%)
Similarity:	430/895 - (48%)	Gaps:	87/895 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KDGGKSRDKKWPWFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSEEALHPDKFIGERAMRQLAE 76
            :.||:||..|.....|  ..|.|.||:..|:........:.|..|..:....:|...:|...|..
  Rat    50 ESGGESRGAKTALSEA--RTALALALYLLALRALVQLSLQRLVLSRTSGLQGEFDARQARVYLEH 112

  Fly    77 YSAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAF---HLWGMTISYTN 138
            .:|||.:.:||..||:.|:.:||.:|..|::::. .|:.|.||.|..:|:|   .|.|.|..|.|
  Rat   113 ITAIGPRTTGSAENEILTVQYLLEQITLIEEQSN-SLHRISVDVQRPTGSFSIDFLGGFTSYYDN 176

  Fly   139 LSNVVVKISQKSSDNENY-LLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTHPVVF 202
            ::|||||:  :..|...| :|.|.|:||...:|.|.||.|...||||.|||::.|...|.|.|||
  Rat   177 ITNVVVKL--EPQDGAKYAVLANCHFDSVANSPGASDDAVSCAVMLEVLRVMAASPEPLQHAVVF 239

  Fly   203 LFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPY 267
            |||||||..:..||||||||.|:...:|.:||::.|.||:|::|||||.:|||.:.|.::..||:
  Rat   240 LFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAAKHPF 304

  Fly   268 AQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENV 332
            |..:|:|:||...|||||||||:||:|.:||:|:|.:.|||:|||::|....:...:.|..|:|:
  Rat   305 ASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRAGDNI 369

  Fly   333 LPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSVYIMT 397
            |.::..||.:..|.:::.|..|..|::|.||..::.|...|...||.:|.:|..:.:|..:.
  Rat   370 LAVLKYLATSDMLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGRKLL--- 431

  Fly   398 LDNGADAPKAVVLRFAIIFLVQAGTLFV----ACGLTLLVAVFMQGVGLAESWYYGKWMAFGLY- 457
                  .||.....:...||...|..|:    :....|::|||:..:|.:.|||...::|..||
  Rat   432 ------RPKHRNSNYVRDFLCGLGITFISWFTSLVTVLIIAVFVSLIGQSLSWYNYFYIAVCLYG 490

  Fly   458 ---------FCTLFFAFGILPAT--YIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMGI 511
                     ..||...|..:.|:  |:|      .:..|.::  |:|  |..|    :.:|..|.
  Rat   491 TATVAKIILIHTLAKRFYYVNASDLYLG------ELFFDTSL--FVH--CGFL----VALTAQGF 541

  Fly   512 RSSYFPMVGIFFYAISVLVQIVLKLTLKKSY--------FVTVHLLFQVLPFFFYTYICYATLVT 568
            .|:       |..|:.|...::.||.:.|.:        |:.::||...:|:.:..|:.:|....
  Rat   542 CSA-------FMSAVWVAFPLLTKLCVYKDFKKHGAKGRFIALYLLGMFIPYLYGLYLIWAVFEM 599

  Fly   569 FVPMEGRDGPESSPDIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTSA 633
            |.|:.||.|.|..||::::..:....:..:.:.|..::.....|....:..::..:..:|.|:.|
  Rat   600 FTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGA 664

  Fly   634 GFPFVK---QLAPQRYYVLHTQRTFHNLDGT-SKQDSGYYIQPVD--------TRLHELDDTTFK 686
            .||:..   ...|:|.::.|..||||||:|: .|:|||.:|...|        ..:.|::||...
  Rat   665 FFPYSSNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEINDTIRA 729

  Fly   687 NAEPESWTAATCAAEPYCGLPLYSGRWIEWKDSARWIYSSPPVIPMN-INLTQLSKQSLDGNKVR 750
            :.|..:         |.||.|.|..  :.:.....|...:|.:.|.| .:...:||:.:..:.::
  Rat   730 HCEENA---------PLCGFPWYLP--VHFLIRKNWYLPAPEISPRNPAHFRLVSKEKMPWDSIK 783

  Fly   751 YEYNLRASDRVMMYIDPLDNVKVTDWSFDHTPLVEKHTPPYLIYAIYSQTEEPLNFWVELEHEEG 815
            ..:.......:..|:.......::.||..:...|......|.::..:........||:|::....
  Rat   784 LTFEATGPSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEVQQVSE 848

  Fly   816 NTDGPYMKLVVSEHFQYHPEYYTEEYKEFLATFPDWTYTTDWFSALESWI 865
            ......:.:.::.|:.......:.:.......||||::.:.|.|....::
  Rat   849 EQPEGMVTVAIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	132/310 (43%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	61/266 (23%)
Ermp1	XP_006231303.1	M28_Fxna_like	99..406	CDD:193497	132/309 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339530
Domainoid	1	1.000	242	1.000	Domainoid score	I2158
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1759
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm44686
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770