DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and CG9416

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	848	Identity:	370/848 - (43%)
Similarity:	525/848 - (61%)	Gaps:	14/848 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 WFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSEEALHPDKFIGERAMRQLAEYSAIGNKMSGSI 88
            |:.||::.:..|.|||..|:|||:..|::....:|...|.:||||||...|...|.||.|:.||.
  Fly    19 WYWAPLFVSCWFLLFYLVVIPSFHRMPQLKTLEDERQQPGQFIGERAENTLLRLSKIGPKVVGSA 83

  Fly    89 NNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNVVVKISQKSSDN 153
            .||...:.|||.||..|.|:||.||||||.|.|.:||.:.||.|...|.::.|||||:|.|::.:
  Fly    84 ANEQVAVQFLLSEIGDIIDDARTDLYDIEKDVQVASGNYLLWSMVNVYQSIQNVVVKLSPKNATS 148

  Fly   154 ENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTHPVVFLFNGAEEACMLGSHGF 218
            |..||:|||:||...:..|||.|:|.|:|||.||||::.|..||:.||||||||||..:.|||.|
  Fly   149 EAALLINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVVFLFNGAEENPLQGSHAF 213

  Fly   219 ITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAEELFQHNFIPS 283
            ||||.|::|.:|::||||.|:||||:|||:||:||||.|||..::.||:|.|:.|||||:.|:||
  Fly   214 ITQHPWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHPFASTIGEELFQNGFVPS 278

  Fly   284 DTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWALANAPELDNT 348
            :||:|:|||||.:||||||..:|||||||::|.|..:...|||.||||:|.|:.|||||.||:|.
  Fly   279 ETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGENILALVKALANAEELENP 343

  Fly   349 TAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSVYIMTLDNGADA-PKAVVLRF 412
            :.|.:||.:::|.:|||.:.|.|:..|.||:.|.|  .:|:...:||..:.:.... .:.:..:|
  Fly   344 SKYAEGHMIFFDMMGWFFVYYPETTGIIINITVCV--LVCVTIVLYIWMMSSSTGMFRRRIWAKF 406

  Fly   413 AIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYYGKWMAFGLYFCTLFFAFGILPATYIGFTK 477
            .|:..:|...:.:..||.:.:|:|:..|.|..||:...||.||||||.:.|..||:||.|...||
  Fly   407 GILAALQLAGVALGIGLVISIALFLDAVNLPMSWFSQNWMLFGLYFCPMIFGMGIVPAIYFSRTK 471

  Fly   478 RKTNMKLDQTIACFMHAQCILLALLCIIMTIMGIRSSYFPMVGIFFYAISVLVQIVLKLTLKKSY 542
             :..:.|...|...||:.|::|.::..||....|||::..|:.|.||.:|||:.:|.|.......
  Fly   472 -EHGLPLGYGIQLLMHSHCLILTIITAIMVSYSIRSAFVIMLCIGFYTLSVLINLVTKAHKTNFL 535

  Fly   543 FVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDGPESSPDIMISVFIIATAINYAGFVIPIMHK 607
            ::..|.:.|||||.||||.|||..|.||||:||: ..::|:|::..|.....:.:|.|::|:...
  Fly   536 WLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGRE-CNTNPEILMGFFTALMVLLFAPFLVPLFCL 599

  Fly   608 FRKPKIIFSSFGVITIIFIILACTSAGFPFVKQLAPQRYYVLHTQRTFHNLD---GTSKQDSGYY 669
            |||.|.|.|.||:.||:|||.|.|...||:.::.||||::.:||.|||||.|   ..|.:||||:
  Fly   600 FRKSKTIISMFGICTIVFIIFAATPIAFPYAEKTAPQRFFAVHTARTFHNGDPASTVSHKDSGYF 664

  Fly   670 IQPVDTRLHELDDTTFKNAEPESWTAATCAAEPYCGLPLYSGRWIEWKDSARWIYSSPP---VIP 731
            :.|||.|.|.:||..|:|..........|.:|..||.|:||.||:...|::.::....|   .||
  Fly   665 VLPVDRRPHTVDDILFENTNFTKSERIDCDSELMCGFPIYSSRWLNAVDNSYFVPGPEPNREYIP 729

  Fly   732 MNINLTQLSKQSLDGNKVRYEYNLRASDRVMMYIDPLDNVKVTDWSFDHTPLVEKHTPPYLIYAI 796
               .||.|.|.|.....:|::..:...|...::|.||::.|:.||||...||.....|||.:|..
  Fly   730 ---TLTILEKSSNSDTNIRFDLEISGPDHTSIFILPLNDSKLVDWSFIRDPLDGNVKPPYYVYWS 791

  Fly   797 YSQTEEPLNFWVELEHEEGNTDGPYMKLVVSEHFQYHPEYYTEEYKEFLATFPDWTYTTDWFSAL 861
            |:...:||.|.:|.|||:.|..|...|:.:..|..:...|.||:::|||||||.|.:.:.|..:.
  Fly   792 YALDPKPLQFSLEFEHEDPNWSGGTFKIALMGHRIHDDMYITEDFREFLATFPPWAHVSSWLGSY 856

  Fly   862 ESW 864
            .||
  Fly   857 NSW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	171/306 (56%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	85/243 (35%)
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	171/306 (56%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	83/202 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446924
Domainoid	1	1.000	62	1.000	Domainoid score	I3747
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
	13	12.830