DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and NAALADL2

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_011510914.1	Gene:	NAALADL2 / 254827	HGNCID:	23219	Length:	805	Species:	Homo sapiens

Alignment Length:	306	Identity:	57/306 - (18%)
Similarity:	102/306 - (33%)	Gaps:	117/306 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNVVVKISQKSSDN 153
            |||:..::..::.:.|:|                            :.||:...|:.::..
Human   420 NNEIRVVSMQVQTVTKLK----------------------------TVTNVVGFVMGLTSP---- 452

  Fly   154 ENYLLVNSH------YDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTHPVVFLFNGAEEACM 212
            :.|::|.||      |:.:....:.......:..::..::...|.:||    :||        |.
Human   453 DRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRT----IVF--------CS 505

  Fly   213 LGSHGF--ITQHKW--------SKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPY 267
            .|...|  |..::|        .||..|.::|.|...|...:       :|         |..|.
Human   506 WGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSL-------YP---------VASPS 554

  Fly   268 AQTLAEELFQHNF-----------------IPSDTDFRIFRDYGGVPGLDMA----------SVM 305
            .|.|..|  ::||                 |..|.|:  |.::.|||.:..|          |.:
Human   555 LQQLVVE--KNNFNCTRRAQCPETNISSIQIQGDADY--FINHLGVPIVQFAYEDIKTLEGPSFL 615

  Fly   306 NGYVYHT------EFDNFKNVEYGTYQSTGENVLPLIWALANAPEL 345
            :...:.|      |.|...|:.....:.:||.:|    .:||.|.|
Human   616 SEARFSTRATKIEEMDPSFNLHETITKLSGEVIL----QIANEPVL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	57/306 (19%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879
NAALADL2	XP_011510914.1	Peptidases_S8_S53	268..420	CDD:299169	57/306 (19%)
		Zinc_peptidase_like	437..659	CDD:301362	53/289 (18%)
		TFR_dimer	686..>744	CDD:282153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900