DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and SPCC1259.02c

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001342785.1	Gene:	SPCC1259.02c / 2539040	PomBaseID:	SPCC1259.02c	Length:	822	Species:	Schizosaccharomyces pombe

Alignment Length:	905	Identity:	229/905 - (25%)
Similarity:	374/905 - (41%)	Gaps:	196/905 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AAAAFALFYAAVLPSFYSY-PKMLYQSEEALHPDKFIGERAMRQLAEYS-AIGNKMSGSINNEVH 93
            |...||:..|.:...|::: .:.|....:|....:|....|::.:...| .||.::.|:|..| .
pombe    20 AMVLFAVVMARIALYFHNHLDEPLVDPYDANGNPQFSEANALKHVIHLSDDIGYRILGTIEQE-R 83

  Fly    94 TINFLLREI----QKIKDEARLDLYDIEVDTQYSSGA--FHLWGMTI--SYTNLSNVVVKISQ-K 149
            ...:::.|:    ::::|....|::.:||..:...||  |......:  .|.||.|:||::|. .
pombe    84 AREYIMNEVLALQKQLQDGPNADIHQMEVSLESGDGAHRFDFMNKYVIKKYQNLKNIVVRLSNGT 148

  Fly   150 SSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTHPVVFLFNGAEEACMLG 214
            .:..|..:|:|:|.||.:.:|.|.||.:.|.::||.:|:.......|||.:|||||.|||:....
pombe   149 EACKEEAVLINAHVDSTLPSPGATDDALAVAILLEAIRIFISRPVPLTHSIVFLFNDAEESLQDA 213

  Fly   215 SHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAEELFQHN 279
            ||.||||.......|.:|||::.|..|.|:|||...|.  :.|.| :.||||:...||:::|:..
pombe   214 SHMFITQSPLRDTIKCVVNLEACGTTGSEILFQATSNE--MIKAY-SHVPHPFGTVLADDVFRTG 275

  Fly   280 FIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWALANAPE 344
            .|.||||||.|..||.:.|||||.|.|.|:|||:.|....:..||.|:.|||:|.::..|. :||
pombe   276 LILSDTDFRQFVQYGNLTGLDMAVVKNSYLYHTKKDLAPYISPGTPQNFGENILAILTYLV-SPE 339

  Fly   345 LDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSVYIMTLDNGADAPKAVV 409
            .|.......| |||:.........|::..|..:|.:|.       |..: ::|| .|::....|.
pombe   340 ADLNNMKSSG-TVYFSVFNSLFFMYSKLTSKILNTLVG-------GLGI-LLTL-RGSEGSFTVA 394

  Fly   410 LRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYYGKWMAFGLY----FCTLFFAFGILPA 470
            |...:|.:  || :||...:...:...:...|:  ||:..::....:|    |.:|||...:.
pombe   395 LIAQVISI--AG-IFVIPNIWAYILGNVLDCGM--SWFRNEYWPLFIYLPAIFASLFFTESLF-- 452

  Fly   471 TYIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMGIRSSYFPMVGIFFYAISVLVQIVLK 535
                  ||..::.|..||..|.            ::|.:.:.|:|...:..||...::.:..  |
pombe   453 ------KRSEHLALRATIFIFS------------LLTFIPLPSAYLFTIIDFFMVFALFLND--K 497

  Fly   536 LTLKKSYFVTVHLLFQVLPFFFYTYICYAT---------LVTFVPMEGRDGPESSPDIMISVFII 591
            :..|..   |||.|     .:|...|...|         |..|||:.||.|.:...|.:::...:
pombe   498 ILAKPG---TVHPL-----TYFIGSIGAMTVGFESAINLLEIFVPLTGRIGTDKVADNVVATVCV 554

  Fly   592 ATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTSAGF-PFVKQLAPQRYYV--LHTQR 653
            .....|...:.|.:.:||. :..| ..|::..||::      || .|:  ||.|..|.  ||.:|
pombe   555 CGFNIYFPLMSPWIQRFRS-RCCF-RLGLLFSIFVV------GFSSFI--LAKQDTYYDSLHPRR 609

  Fly   654 TF-HNLDGTSKQDSGYYIQPVDT-----RLHE-----LDDTTFKNAEPESWTAATCAAEPYCGLP 707
            .| ..::..:..:...:|...|:     :|..     |.|......|.:.|.:......|:.
pombe   610 IFVQRMENITSNEVSLHIASADSAPGFDKLSSDLSSLLTDEPVVKTEMDDWNSDWDTVYPFS--- 671

  Fly   708 LYSGRWIEWKDSARWIYSSPPVIPMN--INLTQLSKQSLDGNKVRYEYNLRASDRVMMYIDPLDN 770
                   ::..|.|        ||:|  :::|.|.             :::.|::|:.  |.:.|
pombe   672 -------QFLGSYR--------IPLNDTVDVTTLP-------------SIKFSNKVVK--DNVVN 706

  Fly   771 VKVT------------------DWSFDHTPLVEK--HTPPYLIYAI------YSQTEEPLNFWVE 809
            |.||                  .||....|...:  |......|.:      .|..|.|:
pombe   707 VTVTVEHPGLIWTVVSFDADVLSWSLPEVPSTVRRHHVREVSAYGLDSYSFNMSYLEAPI----- 766

  Fly   810 LEHEEGNTDGPYMKLVVSEHFQYHP---------------EYYTEEYKEFLATFPDWTYT 854
                       |...|..:...::|               |..|.:|      .||||.|
pombe   767 -----------YFDFVGVDGVGHYPSKASEGRDRASIQLCEKLTNDY------LPDWTDT 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	111/316 (35%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	52/255 (20%)
SPCC1259.02c	NP_001342785.1	M28_Fxna_like	52..363	CDD:193497	111/316 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	161	1.000	Domainoid score	I973
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	233	1.000	Inparanoid score	I847
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm47049
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
TreeFam	1	0.960	-	-
	13	12.850