DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and CG30047

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_725141.1	Gene:	CG30047 / 246414	FlyBaseID:	FBgn0050047	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	878	Identity:	338/878 - (38%)
Similarity:	510/878 - (58%)	Gaps:	23/878 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TEEKDGG----------------KSRDKKWPWFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSE 57
            :.||:|.                |.|..:.||:.||.:.....|||||.|.|.::..|..:..|.
  Fly     3 SREKNGSAASNSDVALVNVLSQQKLRRHRLPWYYAPSFLLLWVALFYAVVYPLYHRLPDSVLISH 67

  Fly    58 EALHPDKFIGERAMRQLAEYSAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQY 122
            |:..|.:|:.|||.|.|.:|..||.|:.||:.|||.|:.||..|::.|:...|.|||::::|.|:
  Fly    68 ESSKPGQFVAERAQRLLYKYDKIGPKVVGSVANEVTTVAFLEEEVENIRAAMRSDLYELQLDVQH 132

  Fly   123 SSGAFHLWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLR 187
            .|||:..|.|...|..::|||||||.:||::.:|||||||:||:..:|.:||||.|||||||.||
  Fly   133 PSGAYMHWQMVNMYQGVTNVVVKISSRSSNSSSYLLVNSHFDSKPSSPGSGDDGTMVVVMLEVLR 197

  Fly   188 VISRSERTLTHPVVFLFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNH 252
            .::.|:....||:|||||||||..:..||||||||||:.|||||:||:..|:|||::|||:|||:
  Fly   198 QVAISDTPFEHPIVFLFNGAEENPLEASHGFITQHKWAGNCKALINLEVAGSGGRDLLFQSGPNN 262

  Fly   253 PWLAKYYQASVPHPYAQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNF 317
            |||.|||..:..||:|.|:|||:||...:|||||||||||||.:||||||.:.|||||||.|||.
  Fly   263 PWLIKYYYQNAKHPFATTMAEEIFQSGILPSDTDFRIFRDYGQLPGLDMAQISNGYVYHTIFDNV 327

  Fly   318 KNVEYGTYQSTGENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVS 382
            :.|...:.||:|:|.|.|:.|.|:|||:.|...:.:||.|::|:||.|.:.|||:..|.:|..::
  Fly   328 QAVPIDSLQSSGDNALSLVRAFADAPEMQNPEDHSEGHAVFFDYLGLFFVYYTENTGIVLNCCIA 392

  Fly   383 VAAFICIGTSVYIMTLDNGADAPKAVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWY 447
            ||:.:.:..|:..|..::.....: |.:.||||.::....:.::.||.||:||.......:.:::
  Fly   393 VASLVLVVCSLLRMGRESDVSIGR-VSIWFAIILVLHVLGMILSLGLPLLMAVLFDAGDRSMTYF 456

  Fly   448 YGKWMAFGLYFCTLFFAFGILPATYIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMGIR 512
            ...|:..||:....... .|||.|.....|....:.....|...:||.|:||:|:.||:|.:.:|
  Fly   457 SNNWLVIGLFIVPAIIG-QILPLTLYYTLKPNDEISHPNHIHMSLHAHCVLLSLIAIILTAISLR 520

  Fly   513 SSYFPMVGIFFYAISVLVQIVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDG 577
            :.|..|:.:.||..::|:.::..|..:..|:|.:..:.|::||.::.|:.|..|:.|.||.||.|
  Fly   521 TPYLCMMSLLFYGGALLINLLSTLHDRGYYWVVLVQVLQLVPFLYFCYLFYTFLLVFFPMLGRFG 585

  Fly   578 PESSPDIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTSAGFPFVKQLA 642
            ..::||::|::..........|||.|:::.||.||:.....||:|.||.::|.:..|||:..:.:
  Fly   586 HGTNPDLLIALICAVGTFFALGFVAPLINIFRWPKLALLGLGVVTFIFSMIAVSEVGFPYRAKTS 650

  Fly   643 PQRYYVLHTQRTFHNLDGT-SKQDSGYYIQPVDTRLHELDDTTFKNAEPESWTAATCAAEPYCGL 706
            ..|.:.||.:|.|:..||: |..|||||....|.||:...:.|..|....:.|::.|.....||:
  Fly   651 VMRIHFLHVRRIFYEYDGSVSLSDSGYYFDFQDRRLYYPLENTSVNLTGLASTSSECDKYLMCGV 715

  Fly   707 PLYSGRWIEWKDSARWIYSSPPV-IPMNINLTQLSKQSLDGNKV-RYEYNLRASDRVMMYIDPLD 769
            |.::.||.:.:..:.|:.....| ||...:|..|||..||..|| |:|:.:.....:.:||.|||
  Fly   716 PCFNHRWCKTRAKSHWLPREQEVAIPGATSLKLLSKAVLDSGKVARFEFEISGPPHMSLYIQPLD 780

  Fly   770 NVKVTDWSFDHTPLVEKHT--PPYLIYAIYSQTEEPLNFWVELEHEEGNTDGPYMKLVVSEHFQY 832
            .|:|.||||....|.|..|  |||.|:..|.....||.|.::.....|:...|..:|..:..|..
  Fly   781 GVEVEDWSFIRNMLDEPDTYSPPYQIFFAYGADNTPLKFHIDFAKSSGDFSTPTFQLGFAASFVS 845

  Fly   833 HPEYYTEEYKEFLATFPDWTYTTDWFSALESWI 865
            :.........:|::.|||:.:..:|.:..|.:|
  Fly   846 YDYDRDAAGLKFISDFPDFAHVMEWPTLYERYI 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	168/306 (55%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	68/242 (28%)
CG30047	NP_725141.1	M28_Fxna_like	72..379	CDD:193497	168/306 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446930
Domainoid	1	1.000	318	1.000	Domainoid score	I3336
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
	13	12.830