DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and CG30043

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_725143.1	Gene:	CG30043 / 246412	FlyBaseID:	FBgn0050043	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	342/865 - (39%)
Similarity:	503/865 - (58%)	Gaps:	25/865 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GKSRDKKWPWFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSEEALHPDKFIGERAMRQLAEYSA 79
            |..|..:..|:.||.:.....|||||.|:|.:|..|..|..|||:..|.:|:.|||.:.|..|..
  Fly    24 GYVRRPRLSWYYAPSFLLLWLALFYAIVIPLYYRLPDRLTISEESHRPGEFVAERAQQYLYTYDR 88

  Fly    80 IGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNVVV 144
            ||.|::||..|||.|:.||:.|.:||:.|.|.||||:|:|.|..:|.:....|...|..:.||:|
  Fly    89 IGPKVTGSYANEVTTVEFLVNETEKIRAEMRSDLYDLELDVQSPTGGYVFNDMVNMYQGIHNVIV 153

  Fly   145 KISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTHPVVFLFNGAEE 209
            |:|.|||.:|:|||:|||:||:..:|.:||||.|||||:|.||.:|.||....||:|||||||||
  Fly   154 KLSSKSSQSESYLLLNSHFDSKPGSPGSGDDGTMVVVMMEVLRQMSISEIPFEHPIVFLFNGAEE 218

  Fly   210 ACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAEE 274
            ..:..||||||||||::.|||.:||:..|:|||::|||:|||:|||.|||:....||:|.|:|||
  Fly   219 NPLQASHGFITQHKWAEKCKAFINLEVGGSGGRDLLFQSGPNNPWLMKYYRQHAKHPFATTMAEE 283

  Fly   275 LFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTGENVLPLIWAL 339
            :||...:|||:|||||||||.:.|||:|.:.|||||||.||.::||...:.|::|.|||.|:.|.
  Fly   284 IFQSGVLPSDSDFRIFRDYGNIAGLDIAQIENGYVYHTAFDTYENVPGRSIQNSGNNVLALVRAY 348

  Fly   340 ANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSVYIMT-LDNGAD 403
            :||.||.||.: :..|.|::||||.|.:.|||:..|.:|.|:.|.:.:.:|.||:.|. ....|.
  Fly   349 SNASELYNTES-DDSHAVFFDFLGLFFVYYTETTGIVVNCVIGVLSLVLVGCSVWRMCHQSEEAS 412

  Fly   404 APKAVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYYGKWMAFGLYFCTLFFAFGIL 468
            .|:..:...:|:.|...|.|...| |.||:||.......:.:::...|:.||||.|...... :|
  Fly   413 LPQISIWFLSILGLHVVGFLLCIC-LPLLMAVLFDAGDRSLTYFTSNWLVFGLYVCPAIIGL-VL 475

  Fly   469 PATYIGFTKRKTNMKLDQT--IACFMHAQCILLALLCIIMTIMGIRSSYFPMVGIFFYAISVLVQ 531
            |.|.  :.....|.||.|.  :...:||..::.|||.:|:|.||:||.|..::.:.||..::|:.
  Fly   476 PLTL--YYTLLPNEKLSQAYQLQLSLHAHLVVQALLALILTAMGLRSQYLCLISMIFYGGALLIN 538

  Fly   532 IVLKLTLKKSYFVTVHLLFQVLPFFFYTYICYATLVTFVPMEGRDGPESSPDIMISVFIIATAIN 596
            :|..|..:..|:|.:.:..|||||.::.|:.|..||.|:|:.||:|..::||:::.:........
  Fly   539 LVSTLHDRGYYWVPIVMFLQVLPFSYFCYLFYMFLVIFIPVLGRNGYSTNPDLIVGLLCGVCVFF 603

  Fly   597 YAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTSAGFPFVKQLAPQRYYVLHTQRTFHNLDGT 661
            ..||...:::.||.||:|....||:|.||.::|.:..|||:..:....|...|||:|.|:..||:
  Fly   604 ALGFAAQLINMFRWPKLILLGLGVMTFIFCMIAVSDVGFPYRAKTNVMRANCLHTRRIFYEHDGS 668

  Fly   662 -SKQDSGYYIQPVDTR-LHELDDTT--FKNAEPESWTAATCAAEPYCGLPLYSGRWIEWKDSARW 722
             |:.|||||....|.| ...|:|:.  ....||   .|..|.....||:|.:...|.:|:....|
  Fly   669 VSRSDSGYYFNYQDRRAFAPLEDSALDLTGLEP---VANRCDDYVMCGIPCFYYSWCKWRQWDGW 730

  Fly   723 I-YSSPPVIPMNINLTQLSKQSLD-GNKVRYEYNLRASDRVMMYIDPLDNVKVTDWSFDHTPL-- 783
            : ..|..::|..:.|..|....|: |...|||:.|.....:.::|.|:.:.||.||||....|
  Fly   731 LPRESEVILPGELTLDFLGYTVLESGTVARYEFELAGPPHMNLFIQPVGSAKVDDWSFVRKMLDE 795

  Fly   784 VEKHTPPYLIYAIYSQTEEPLNFWVELEHEEGNTDGPYMKLVVSEH---FQYHPEYYTEEYKEFL 845
            .|:..|||.|:..|......|.|::::|..:|..|.|.::|....|   |:|..:   .|.|:|:
  Fly   796 PEEFQPPYQIFHSYGTDNTSLKFFIDMEKPDGIFDTPTLELAAVGHWVSFEYERD---AEAKDFV 857

  Fly   846 ATFPDWTYTTDWFSALESWI 865
            |.|||:.:..:|.|..:.:|
  Fly   858 AAFPDFVHVMEWPSIFKRYI 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	164/306 (54%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	77/245 (31%)
CG30043	NP_725143.1	M28_Fxna_like	71..377	CDD:193497	164/306 (54%)
CG30043	NP_725143.1	PMT_2	493..>634	CDD:304453	47/140 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446931
Domainoid	1	1.000	248	1.000	Domainoid score	I4889
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800